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| __NOTOC__
| | #REDIRECT [[Captopril#Use in Specific Populations]] |
| {{Captopril}}
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| {{CMG}}; {{AE}} {{AM}}
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| ===Nursing Mothers===
| | [[Category: Cardiovascular Drugs]] |
| | | [[Category: Drug]] |
| Concentrations of captopril in human milk are approximately one percent of those in maternal blood. Because of the potential for serious adverse reactions in nursing infants from captopril, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of captopril to the mother.
| | [[Category:ACE inhibitors]] |
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| ===Pediatric Use===
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| ====Neonates with a history of in utero exposure to captopril====
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| If [[oliguria]] or [[hypotension]] occurs, direct attention toward support of blood pressure and renal perfusion. Exchange transfusions or dialysis may be required as a means of reversing hypotension and/or substituting for disordered renal function. While captopril may be removed from the adult circulation by [[hemodialysis]], there is inadequate data concerning the effectiveness of hemodialysis for removing it from the circulation of neonates or children [[Peritoneal dialysis]] is not effective for removing captopril; there is no information concerning exchange transfusion for removing captopril form the general circulation.
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| Safety and effectiveness in pediatric patients have not been established. There is limited experience reported in the literature with the use of captopril in the pediatric population; dosage, on a weight basis, was generally reported to be comparable to or less than that used in adults.
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| Infants, especially newborns, may be more susceptible to the adverse hemodynamic effects of captopril. Excessive, prolonged and unpredictable decreases in blood pressure and associated complications, including oliguria and [[seizures]], have been reported.
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| Captopril should be used in pediatric patients only if other measures for controlling blood pressure have not been effective.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = CAPTOPRIL (CAPTOPRIL ) TABLET CAPTOPRIL TABLET [APOTEX CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=2c0f1ee3-b2b7-a1bc-059a-d65bea6cd0ef | publisher = | date = | accessdate =}}</ref>
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| ==References==
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| {{Reflist}}
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| {{FDA}}
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| [[Category:Cardiovascular Drugs]] | |
| [[Category:Drugs]] | |