Community-acquired pneumonia causes: Difference between revisions

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{{Community-acquired pneumonia}}
{{Community-acquired pneumonia}}
{{CMG}}; {{AE}} {{chetan}}
{{CMG}}; {{AE}} {{chetan}}; {{AL}}
 
==Overview==
==Overview==
[[Pneumonia]] can be caused by viral, bacterial, and fungal organisms. The etiology depends upon various factors like age, immune status, geographical area, and comorbid conditions.
 
Community-acquired pneumonia can be caused by viral, bacterial, and fungal organisms. Causative etiology varies with age, immune status, epidemiologic background, and comorbidity. The most common cause of CAP in adult outpatients and inpatients is ''Streptococcus pneumoniae''.  Patients admitted to the intensive care unit tend to have more aggressive organisms such as ''Staphylococcus aureus'' and Gram-negative bacilli.  Neonates are most susceptible to Group-B-Streptococcus (GBS) which causes approximately 50% of pneumonias in the first week of life.  Children and elderly patients are more susceptible to viral infections as well atypical bacterial pneumonias (Mycoplasma, Chlamydia, Legionella).


==Causes==
==Causes==
===Most Common Etiologies for Community-Acquired Pneumonia <small><ref name="pmid17278083">{{cite journal |author=Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG |title=Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults |journal=[[Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America]] |volume=44 Suppl 2 |issue= |pages=S27–72 |year=2007 |month=March |pmid=17278083 |doi=10.1086/511159 |url=http://www.cid.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17278083 |accessdate=2012-09-06}}</ref><ref name="Wong-2013">{{Cite journal  | last1 = Wong | first1 = KK. | last2 = Fistek | first2 = M. | last3 = Watkins | first3 = RR. | title = Community-acquired pneumonia caused by Yersinia enterocolitica in an immunocompetent patient. | journal = J Med Microbiol | volume = 62 | issue = Pt 4 | pages = 650-1 | month = Apr | year = 2013 | doi = 10.1099/jmm.0.053488-0 | PMID = 23242642 }}</ref><ref name="Oh-2013">{{Cite journal  | last1 = Oh | first1 = YJ. | last2 = Song | first2 = SH. | last3 = Baik | first3 = SH. | last4 = Lee | first4 = HH. | last5 = Han | first5 = IM. | last6 = Oh | first6 = DH. | title = A case of fulminant community-acquired Acinetobacter baumannii pneumonia in Korea. | journal = Korean J Intern Med | volume = 28 | issue = 4 | pages = 486-90 | month = Jul | year = 2013 | doi = 10.3904/kjim.2013.28.4.486 | PMID = 23864808 }}</ref></small>===
{| style="border: 0px; font-size: 85%; margin: 3px; width:700px;" align=center
|valign=top|
|+
! style="background: #4479BA; color:#FFF;  width: 250px;" | Outpatient
! style="background: #4479BA; color:#FFF;  width: 250px;" | Inpatient (non-ICU)
! style="background: #4479BA; color:#FFF;  width: 250px;" | Inpatient (ICU)
|-
| style="padding: 5px 5px; background: #F5F5F5;" |
#[[Streptococcus pneumoniae]]
#[[Mycoplasma pneumoniae]]
#[[Haemophilus influenzae]]
#[[Chlamydophila pneumoniae]]
#[[Influenza|Influenza A and B]], [[adenovirus]], [[respiratory syncytial virus]], [[parainfluenza]]
| style="padding: 5px 5px; background: #F5F5F5;" |
#[[Streptococcus pneumoniae]]
#[[Mycoplasma pneumoniae]]
#[[Haemophilus influenzae]]
#[[Legionella]]
#[[Aspiration]]
#[[Influenza|Influenza A and B]], [[adenovirus]], [[respiratory syncytial virus]], [[parainfluenza]]
#[[Yersinia enterocolitica]]
| style="padding: 5px 5px; background: #F5F5F5;" |
#[[Streptococcus pneumoniae]]
#[[Staphylococcus aureus]]
#[[Legionella]]
#[[Gram-negative bacilli]]
#[[Haemophilus influenzae]]
#[[Acinetobacter baumannii]]
|}
===Common Causes by Age Group===
{| style="border: 0px; font-size: 85%; margin: 3px; width:700px;" align=center
|valign=top|
|+
! style="background: #4479BA; color:#FFF;  width: 100px;" | Age Group
! style="background: #4479BA; color:#FFF;  width: 250px;" | Neonates
! style="background: #4479BA; color:#FFF;  width: 250px;" | Children
! style="background: #4479BA; color:#FFF;  width: 250px;" | Adults
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Bacteria
| style="padding: 5px 5px; background: #F5F5F5;" |
# ''[[Listeria monocytogenes]]''
# ''[[Mycobacterium tuberculosis]]''
| style="padding: 5px 5px; background: #F5F5F5;" |
# ''[[Mycoplasma pneumoniae]]''
# ''[[Chlamydophila pneumoniae]]''
# ''[[Legionella pneumophila]]''
# ''[[Chlamydia trachomatis]]''
| style="padding: 5px 5px; background: #F5F5F5;" |
'''Typical Bacteria'''
# ''[[Streptococcus pneumoniae]]''
# ''[[Haemophilus influenzae]]''
# ''[[Escherichia coli]]''
# ''[[Klebsiella pneumoniae]]''
# ''[[Pseudomonas aeruginosa]]''
'''Atypical Bacteria'''
# ''[[Mycoplasma pneumoniae]]''
# ''[[Chlamydophila pneumoniae]]''
# ''[[Legionella pneumophila]]''
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" | Virus
| style="padding: 5px 5px; background: #F5F5F5;" |
# [[Herpes simplex virus]]
# [[Adenovirus]]
# [[Mumps]]
# [[Enterovirus]]
| style="padding: 5px 5px; background: #F5F5F5;" |
# [[Respiratory syncytial virus|Respiratory syncytial virus (RSV)]]
# [[Metapneumovirus]]
# [[Adenovirus]]
# [[Parainfluenza]]
# [[Influenza]]
# [[Rhinovirus]]
| style="padding: 5px 5px; background: #F5F5F5;" |
# [[Influenza]]
# [[Parainfluenza]]
# [[Respiratory syncytial virus|Respiratory syncytial virus (RSV)]]
# [[Metapneumovirus]]
# [[Adenovirus]]
|}
* Newborn [[infant]]s, [[children]], and [[adult]]s are at risk for different spectrums of disease causing microorganisms.
* Newborn [[infant]]s, [[children]], and [[adult]]s are at risk for different spectrums of disease causing microorganisms.
* In addition, adults with [[chronic (medicine)|chronic]] illnesses, who live in certain parts of the world, who reside in [[nursing home]]s, who have recently been treated with [[antibiotic]]s, or who are [[alcoholism|alcoholics]] are at risk for unique infections.
* In addition, adults with [[chronic (medicine)|chronic]] illnesses, who live in certain parts of the world, who reside in [[nursing home]]s, who have recently been treated with [[antibiotic]]s, or who are [[alcoholism|alcoholics]] are at risk for unique infections.
===Infants===
====Source of Infection====
* Aerosol


=====Newborn=====
===Infants and Newborns===


* GBS causes at least 50% of cases of CAP in the first week of life.{{ref|Webber}}
* GBS causes at least 50% of cases of CAP in the first week of life.{{ref|Webber}}
* Other bacterial causes in the newborn period include ''[[Listeria monocytogenes]]'' and [[tuberculosis]]
* Other bacterial causes in the newborn period include ''[[Listeria monocytogenes]]'' and ''[[Mycobacterium tuberculosis]]''.
* Viral causes like [[herpes simplex virus]] (most common) [[adenovirus]], [[mumps]], and [[enterovirus]]
* Viral causes like [[herpes simplex virus]] (most common), [[adenovirus]], [[mumps]], and [[enterovirus]].
 
===Children===
===Children===
* For the most part, children older than one month are at risk for the same microorganisms as adults.
* For the most part, children older than one month are at risk for the same microorganisms as adults.
* However, children less than five years are much less likely to have pneumonia caused by ''[[mycoplasma pneumoniae]]'', ''[[chlamydophila pneumoniae]]'', or ''[[Legionella|legionella pneumophila]]''.<ref name="Shachor-Meyouhas-2012">{{Cite journal  | last1 = Shachor-Meyouhas | first1 = Y. | last2 = Arad-Cohen | first2 = N. | last3 = Zaidman | first3 = I. | last4 = Gefen | first4 = A. | last5 = Kassis | first5 = I. | title = [Legionella pneumonia in a child with leukemia]. | journal = Harefuah | volume = 151 | issue = 8 | pages = 479-82, 496 | month = Aug | year = 2012 | doi =  | PMID = 23350295 }}</ref>
* Children less than five years are much less likely to have pneumonia caused by ''[[Mycoplasma pneumoniae]]'', ''[[Chlamydophila pneumoniae]]'', or ''[[Legionella|Legionella pneumophila]]''.<ref name="Shachor-Meyouhas-2012">{{Cite journal  | last1 = Shachor-Meyouhas | first1 = Y. | last2 = Arad-Cohen | first2 = N. | last3 = Zaidman | first3 = I. | last4 = Gefen | first4 = A. | last5 = Kassis | first5 = I. | title = [Legionella pneumonia in a child with leukemia]. | journal = Harefuah | volume = 151 | issue = 8 | pages = 479-82, 496 | month = Aug | year = 2012 | doi =  | PMID = 23350295 }}</ref>
* In contrast, older children and teenagers are more likely to acquire ''[[mycoplasma pneumoniae]]'' and ''[[chlamydophila pneumoniae]]'' than adults.{{ref|Wubbel}}
* In contrast, older children and teenagers are more likely to acquire ''[[Mycoplasma pneumoniae]]'' and ''[[Chlamydophila pneumoniae]]'' than adults.{{ref|Wubbel}}
* A unique cause of CAP in this group is ''[[chlamydia trachomatis]]'', which is acquired during birth but does not cause pneumonia until 2-4 weeks later.
* A unique cause of CAP in this group is ''[[Chlamydia trachomatis]]'', which is acquired during birth but does not cause pneumonia until 2-4 weeks later.
* Common viruses include [[respiratory syncytial virus]] (RSV), [[metapneumovirus]], [[adenovirus]], [[parainfluenza]], [[influenza]], and [[rhinovirus]].
* Common viruses include [[respiratory syncytial virus|respiratory syncytial virus (RSV)]], [[metapneumovirus]], [[adenovirus]], [[parainfluenza]], [[influenza]], and [[rhinovirus]].
* RSV in particular is a common source of illness and hospitalization.{{ref|Abzug}}
* [[RSV]] in particular is a common source of illness and hospitalization.{{ref|Abzug}}
* Fungi and parasites are not typically encountered in otherwise healthy infants, though maternally-derived [[syphilis]] can be a cause of CAP in this age group.
* Fungi and parasites are not typically encountered in otherwise healthy infants, though maternally-derived [[syphilis]] can be a cause of CAP in this age group.


===Adults===
===Adults===
====Viruses====
The causes of CAP in adults are outlined in the following categories.
* Viruses cause 20% of CAP cases.
======Viruses======
 
* Viruses account for about 20% cases of CAP.
* Common viruses are [[influenza]], [[parainfluenza]], [[respiratory syncytial virus]], [[metapneumovirus]], and [[adenovirus]].
* Common viruses are [[influenza]], [[parainfluenza]], [[respiratory syncytial virus]], [[metapneumovirus]], and [[adenovirus]].
* Less common viruses include [[varicella|chicken pox]], [[SARS]], [[H5N1|avian flu]], and [[hantavirus]].{{ref|Roux}}
* Less common viruses include [[varicella|chicken pox]], [[SARS]], [[H5N1|avian flu]], and [[hantavirus]].{{ref|Roux}}
====Atypical Organisms====
*[[Mycoplasma pneumoniae]], [[chlamydophila pneumoniae]], and [[Legionella|legionella pneumophila]] are often grouped as atypical pneumonia. Community acquired pneumonia caused by these agents present insidiously, with a non-productive cough and prominent extra-pulmonary complaints, such as myalgias and diarrhea (lack the typical pneumonia symptoms of fever, cough, and sputum).
* Mycoplasma pneumonia is often called is "walking pneumonia." It is transmitted via respiratory droplets and is common among healthy individuals in close contact with one another, such as dormitories or military barracks.
* Atypical organisms are more difficult to grow, respond to different antibiotics, and were discovered more recently than the typical bacteria discovered in the early [[twentieth century]].


====Streptococcus Pneumoniae====
======''Streptococcus pneumoniae''======
* '''Streptococcus pneumoniae''' is the most common cause of [[community acquired pneumonia]].
 
* Aspiration pneumonia is most commonly caused by anaerobic organisms.
* ''[[Streptococcus pneumoniae]]'' is the most common cause of community-acquired pneumonia.
* [[Aspiration pneumonia]] is most commonly caused by [[anaerobic]] organisms.
* Prior to the development of antibiotics and vaccination, it was a leading cause of death.
* Prior to the development of antibiotics and vaccination, it was a leading cause of death.
* Traditionally, it was highly sensitive to [[penicillin]], but during the [[1970s]] resistance to multiple antibiotics began to develop.
* Traditionally, it was highly sensitive to [[penicillin]], but during the 1970s resistance to multiple antibiotics began to develop.
* Current strains of "drug resistant Streptococcus pneumoniae" or DRSP are common, accounting for twenty percent of all streptococcus pneumoniae infections.
* Current strains of drug resistant ''[[Streptococcus pneumoniae]]'' (DRSP) are common, accounting for twenty percent of all [[streptococcal]] infections.
* Adults with risk factors for DRSP including being older than 65, having exposure to children in [[day care]], alcoholism, other severe underlying disease, or recent treatment with antibiotics should initially be treated with antibiotics effective against DRSP.{{ref|Ruhe}}
* risk factors for DRSP in adults include: being older than 65, having exposure to children in day care, [[alcoholism]], other severe underlying disease, or recent treatment with antibiotics; individuals exposed to these risk factors should initially be treated with antibiotics effective against DRSP.{{ref|Ruhe}}
====Hemophilus Influenzae====
* Another common bacterial cause of CAP.
* First discovered in [[1892]], it was initially believed to be the cause of influenza because it commonly causes CAP in people who have suffered recent lung damage from viral pneumonia.
====Enteric Gram Negative Bacteria====
* Involve colonic bacteria E.coli and K.pneumonia
* Adults with risk factors for infection, which include living in a [[nursing home]], serious [[heart disease|heart]] and [[lung disease]], and recent antibiotic use should initially be treated with antibiotics effective against Enteric Gram negative bacteria.
====Pseudomonas Aeruginosa====
* Uncommon cause of CAP, but it is a particularly difficult bacteria to treat.
* Individuals who are malnourished, have [[bronchiectasis]], are on [[corticosteroids]], or have recently had strong antibiotics for a week or more, should initially be treated with antibiotics effective against [[Pseudomonas aeruginosa]].{{ref|Lieberman}}


====Special Situations====
======Atypical Organisms======
* Coccidioides are common in southwestern US.
* ''[[Mycoplasma pneumoniae]]'', ''[[Chlamydophila pneumoniae]]'', and ''[[Legionella|Legionella pneumophila]]'' are often grouped as atypical pneumonia. Community-acquired pneumonia caused by these agents present insidiously, with a non-productive [[cough]] and prominent extra-pulmonary complaints, such as [[myalgia]]s and [[diarrhea]] (lack the typical [[pneumonia]] symptoms of [[fever]], [[cough]], and [[sputum]]).
* Anaerobic infection is common in alcoholics. Pneumococcal pneumonia remains the most common cause of CAP in alcoholics too.
 
* [[Psittacosis]] (due to [[Chlamydophila psittaci]]) should be considered in the patient with exposure to birds or bird droppings.
* ''[[Mycoplasma pneumoniae]]'' is often referred to as "walking pneumonia." It is transmitted via respiratory droplets and is common among healthy individuals in close contact with one another in settings such as dormitories or military barracks.
* [[Anaerobes]] are common in patients with poor dental hygiene, and a suspected large volume of aspiration.
 
* [[Streptococcus pneumoniae]], [[H.influenza]], [[moraxella catarrhalis]], and [[legionella]] species are the common causes of community acquired pneumonia in [[chronic obstructive pulmonary disorders]] and [[smokers]].
* Atypical organisms are more difficult to grow and respond to different antibiotics; they were discovered more recently than the typical bacteria discovered in the early twentieth century.
* [[S. pneumonia]], gram negative bacilli, [[H.influenza]], [[staphylococcus aureus]], anaerobes, and [[chlamydiae pneumonia]] are more common in nursing home residents.
 
* [[S. pneumonia]], [[H.influenza]], and [[mycobacterium tuberculosis]] are common pathogens in early stages of HIV, whereas, [[P.jiroveci]], [[histoplasma]], and [[cryptococcus]] are commonly seen in late stages HIV.
======''Haemophilus influenzae''======
* In patients with structural lung disease such as [[bronchiectasis]] and [[cystic fibrosis]], [[pseudomonas aeruginosa]], [[Burkholderia cepacia]] (pseudomonas), and [[staphylococcus aureus]] are the common pathogens involved.
 
==Aspiration Pneumonia Causes==
* ''[[Haemophilus influenzae]]'' used to be a common bacterial cause of CAP.
* Incompetent [[swallowing]] mechanism, such as in neurological disease (a common cause being [[cerebrovascular accident|strokes]]) or while a person is [[Drunkenness|intoxicated]].
* First discovered in 1892, it was initially believed to be the cause of [[influenza]] because it commonly causes CAP in people who have suffered recent lung damage from viral pneumonia.
 
======Enteric Gram-Negative Bacteria======
 
* Enteric bacteria such as ''[[Escherichia coli]]'' and ''[[Klebsiella pneumoniae]]'' may cause commnity-acquired penumonia.
* risk factors in adults for infection include: living in a [[nursing home]], serious [[heart disease|heart]] and [[lung disease]], and recent antibiotic use; these individuals should initially be treated with antibiotics effective against enteric Gram-negative bacteria.
 
======''Pseudomonas aeruginosa''======
 
* ''[[Pseudomonas aeruginosa]]'' is an uncommon cause of CAP, but it is a particularly difficult bacteria to treat.
* Individuals who are malnourished, have [[bronchiectasis]], are on [[corticosteroids]], or have recently had strong antibiotics for a week or more, should initially be treated with antibiotics effective against ''[[Pseudomonas aeruginosa]]''.{{ref|Lieberman}}
 
======Special Situations======
 
* [[Coccidioidomycosis|Coccidioides spp.]] are common in southwestern area of the United States.
* [[Anaerobic]] infection is common in alcoholics. [[Pneumococcal]] pneumonia remains the most common cause of CAP in alcoholics.
* [[Psittacosis]] (caused by ''[[Chlamydophila psittaci]]'') should be considered in the patient with exposure to birds or bird droppings.
* [[Anaerobes]] are common in patients with poor dental hygiene and a suspected large volume of aspiration.
* ''[[Streptococcus pneumoniae]]'', ''[[Haemophilus influenzae]]'', ''[[Moraxella catarrhalis]]'', and ''[[Legionella]]'' species are the common causes of community acquired pneumonia in those with chronic obstructive pulmonary disorders and smokers.
* ''[[Streptococcus pneumoniae]]'', [[Gram-negative bacilli]], ''[[Haemophilus influenzae]]'', ''[[Staphylococcus aureus]]'', [[anaerobe]]s, and ''[[Chlamydophila pneumoniae]]'' are more common in nursing home residents.
* ''[[Streptococcus pneumoniae]]'', ''[[Haemophilus influenzae]]'', and ''[[Mycobacterium tuberculosis]]'' are common pathogens in early stages of [[HIV]], whereas, ''[[Pneumocystis jiroveci]]'', ''[[Histoplasma]]'', and ''[[Cryptococcus]]'' are commonly seen in late stages [[HIV]].
* In patients with structural lung disease such as [[bronchiectasis]] and [[cystic fibrosis]], ''[[Pseudomonas aeruginosa]]'', ''[[Burkholderia cepacia]]'', and ''[[Staphylococcus aureus]]'' are the common pathogens involved.
 
======Aspiration Pneumonia======
 
* Incompetent [[swallowing]] mechanism, as can be found in neurological disease (a common cause being [[cerebrovascular accident|strokes]]) or while a person is [[Drunkenness|intoxicated]].
* [[Iatrogenic]] causes such as [[general anaesthesia]] for an [[Surgery|operation]]. Patients are therefore instructed to be [[nil per os]] (NPO) for at least four hours before surgery.
* [[Iatrogenic]] causes such as [[general anaesthesia]] for an [[Surgery|operation]]. Patients are therefore instructed to be [[nil per os]] (NPO) for at least four hours before surgery.
* Whether aspiration pneumonia represents a true bacterial infection or a chemical inflammatory process remains the subject of significant controversy.
* Whether [[aspiration pneumonia]] represents a true bacterial infection or a chemical inflammatory process remains the subject of significant controversy.
 
===Causes by Organ System===
 
{|style="width:80%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" |'''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | No underlying causes
|-
|bgcolor="LightSteelBlue"| '''Chemical/Poisoning'''
|bgcolor="Beige"| No underlying cause
|-bgcolor="LightSteelBlue"
| '''Dental'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Endocrine'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Environmental'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Genetic'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Iatrogenic'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Infectious Disease'''
|bgcolor="Beige"| [[Acinetobacter baumannii]], [[Actinomycosis]], [[Adenovirus|Adenovirus (serotype 1, 2, 3, 4, 5, 7, 14, 21, 35)]], [[AIDS|AIDS-related opportunistic infections]], [[Aspergillosis]], [[Aspiration]], [[Bacillus anthracis]], [[Bird flu|Bird flu (avian influenza)]], [[Blastomycosis]], [[Burkholderia cepacia]], [[Burkholderia pseudomallei]], [[Chlamydophila pneumoniae]], [[Chickenpox]], [[Coccidioides immitis]], [[Coronavirus]], [[Coxiella burnetii|Coxiella burnetii (Q fever)]], [[Cryptococcus neoformans]], [[Cytomegalovirus]], [[Escherichia coli]], [[Enterovirus]], [[Francisella tularensis]], [[Gram-negative bacilli]], [[Haemophilus influenzae]], [[Influenza A virus subtype H1N1|H1N1 flu]], [[Hantavirus]], [[Herpes simplex virus]], [[Histoplasma capsulatum]], [[Histoplasmosis]], [[Human bocavirus]], [[parechovirus|Human parechovirus types 1, 2, and 3]], [[Influenza]], [[Klebsiella pneumoniae]], [[Legionella micdadei]], [[Legionella pneumophila|Legionella pneumophila (Legionnaires' disease)]], [[Listeria monocytogenes]], [[Mycoplasma pneumoniae]], [[Measles]], [[Melioidosis]], [[Metapneumovirus]], [[Middle East respiratory syndrome coronavirus]], [[Moraxella catarrhalis]], [[Mumps]], [[Mycobacterium avium-intracellulare]], [[Mycobacterium haemophilum]], [[Mycobacterium kansasii]], [[Neisseria meningitidis]], [[Coronavirus|New Haven coronavirus]], [[Nocardia]], [[Paragonimiasis]], [[Parainfluenza]], [[Pneumocystis jiroveci]], [[Pneumonic plague]], [[Proteus]], [[Pseudomonas aeruginosa]], [[Chlamydophila psittaci|Chlamydophila psittaci (psittacosis)]], [[Rat-bite fever]], [[Respiratory syncytial virus|Respiratory syncytial virus (RSV)]], [[Rhinovirus]], [[Rhodococcus equi]], [[Streptococcus pneumoniae|Streptococcus pneumoniae (pneumococcus)]], [[SARS]], [[Serratia]], [[Severe acute respiratory syndrome]], [[Sporotrichosis ]], [[Staphylococcus aureus]], [[Streptococcus agalactiae|Streptococcus agalactiae (group B streptococcus)]], [[Streptococcus pyogenes|Streptococcus pyogenes (group A streptococcus)]], [[Streptococcus pneumoniae]], [[Swine flu]], [[Toxocariasis ]], [[Toxoplasma gondii]], [[Trichosporon ]], [[Trypanosomiasis]], [[Typhus]], [[Varicella-zoster virus]], [[Yersinia enterocolitica]], [[Yersinia pestis]], [[Zygomycosis]]
|-bgcolor="LightSteelBlue"
| '''Musculoskeletal/Orthopedic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Nutritional/Metabolic'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Oncologic'''
|bgcolor="Beige"| No underlying cause
|-bgcolor="LightSteelBlue"
| '''Ophthalmologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Overdose/Toxicity'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Renal/Electrolyte'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Rheumatology/Immunology/Allergy'''
|bgcolor="Beige"| No underlying cause
|-
|-bgcolor="LightSteelBlue"
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Trauma'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
|-
|-bgcolor="LightSteelBlue"
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying cause
|-
|}
 
===Causes in Alphabetical Order===
{{col-begin|width=80%}}
{{col-break|width=33%}}
* [[Acinetobacter baumannii]]
 
* [[Actinomycosis]]
 
* [[Adenovirus|Adenovirus (serotype 1, 2, 3, 4, 5, 7, 14, 21, 35)]]
 
* [[AIDS|AIDS-related opportunistic infections]]
 
* [[Aspergillosis]]
 
* [[Aspiration]]
 
* [[Bacillus anthracis]]
 
* [[Bird flu|Bird flu (avian influenza)]]
 
* [[Blastomycosis]]
 
* [[Burkholderia cepacia]]
 
* [[Burkholderia pseudomallei]]
 
* [[Chlamydophila pneumoniae]]
 
* [[Chickenpox]]
 
* [[Coccidioides immitis]]
 
* [[Coronavirus]]
 
* [[Coxiella burnetii|Coxiella burnetii (Q fever)]]
 
* [[Cryptococcus neoformans]]
 
* [[Cytomegalovirus]]
 
* [[Escherichia coli]]
 
* [[Enterovirus]]
 
* [[Francisella tularensis]]
 
* [[Gram-negative bacilli]]
 
* [[Influenza A virus subtype H1N1|H1N1 flu]]
 
* [[Haemophilus influenzae]]
 
* [[Hantavirus]]
 
* [[Herpes simplex virus]]
 
* [[Histoplasma capsulatum]]
 
{{col-break|width=33%}}
 
* [[Histoplasmosis]]
 
* [[Human bocavirus]]
 
* [[parechovirus|Human parechovirus types 1, 2, and 3]]
 
* [[Influenza]]
 
* [[Klebsiella pneumoniae]]
 
* [[Legionella micdadei]]
 
* [[Legionella pneumophila|Legionella pneumophila (Legionnaires' disease)]]
 
* [[Listeria monocytogenes]]
 
* [[Mycoplasma pneumoniae]]


==Infectious Diseases Society of America/American Thoracic Society consensus statement on common etiologies of community-acquired pneumonia in adults. <ref name="pmid17278083">{{cite journal |author=Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG |title=Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults |journal=[[Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America]] |volume=44 Suppl 2 |issue= |pages=S27–72 |year=2007 |month=March |pmid=17278083 |doi=10.1086/511159 |url=http://www.cid.oxfordjournals.org/cgi/pmidlookup?view=long&pmid=17278083 |accessdate=2012-09-06}}</ref> (DO NOT EDIT)==
* [[Measles]]
 
* [[Melioidosis]]
 
* [[Metapneumovirus]]
 
* [[Middle East respiratory syndrome coronavirus]]
 
* [[Moraxella catarrhalis]]
 
* [[Mumps]]
 
* [[Mycobacterium avium-intracellulare]]
 
* [[Mycobacterium haemophilum]]
 
* [[Mycobacterium kansasii]]
 
* [[Mycoplasma pneumoniae]]
 
* [[Neisseria meningitidis]]
 
* [[Coronavirus|New Haven coronavirus]]
 
* [[Nocardia]]
 
* [[Paragonimiasis]]
 
* [[Parainfluenza]]
 
* [[Pneumocystis jiroveci]]
 
* [[Pneumonic plague]]
 
{{col-break|width=33%}}
 
* [[Proteus]]
 
* [[Pseudomonas aeruginosa]]
 
* [[Chlamydophila psittaci|Chlamydophila psittaci (psittacosis)]]
 
* [[Rat-bite fever]]
 
* [[Respiratory syncytial virus|Respiratory syncytial virus (RSV)]]
 
* [[Rhinovirus]]
 
* [[Rhodococcus equi]]
 
* [[Streptococcus pneumoniae|Streptococcus pneumoniae (pneumococcus)]]
 
* [[SARS]]
 
* [[Serratia]]
 
* [[Severe acute respiratory syndrome]]
 
* [[Sporotrichosis ]]
 
* [[Staphylococcus aureus]]
 
* [[Streptococcus agalactiae|Streptococcus agalactiae (group B streptococcus)]]
 
* [[Streptococcus pyogenes|Streptococcus pyogenes (group A streptococcus)]]


===Outpatient===
* [[Streptococcus pneumoniae]]
* [[Streptococcus pneumoniae]]
* [[Mycoplasma pneumoniae]]
 
* [[Haemophilus influenzae]]
* [[Swine flu]]
* [[Chlamydophila pneumoniae]]
 
* [[Respiratory viruses]]
* [[Toxocariasis ]]
===Inpatient (non-ICU)===
 
* S. pneumoniae
* [[Toxoplasma gondii]]
* M. pneumoniae
 
* C. pneumoniae
* [[Trichosporon ]]
* H. influenzae
 
* Legionella species
* [[Trypanosomiasis]]
* Aspiration
 
* Respiratory viruses
* [[Typhus]]
* Yersinia enterocolitica<ref name="Wong-2013">{{Cite journal  | last1 = Wong | first1 = KK. | last2 = Fistek | first2 = M. | last3 = Watkins | first3 = RR. | title = Community-acquired pneumonia caused by Yersinia enterocolitica in an immunocompetent patient. | journal = J Med Microbiol | volume = 62 | issue = Pt 4 | pages = 650-1 | month = Apr | year = 2013 | doi = 10.1099/jmm.0.053488-0 | PMID = 23242642 }}</ref>
 
===Inpatient (ICU)===
* [[Varicella-zoster virus]]
* S. pneumoniae
 
* Staphylococcus aureus
* [[Yersinia enterocolitica]]
* Legionella species
 
* Gram-negative bacilli
* [[Yersinia pestis]]
* H. influenzae
 
*Acinetobacter baumannii<ref name="Oh-2013">{{Cite journal  | last1 = Oh | first1 = YJ. | last2 = Song | first2 = SH. | last3 = Baik | first3 = SH. | last4 = Lee | first4 = HH. | last5 = Han | first5 = IM. | last6 = Oh | first6 = DH. | title = A case of fulminant community-acquired Acinetobacter baumannii pneumonia in Korea. | journal = Korean J Intern Med | volume = 28 | issue = 4 | pages = 486-90 | month = Jul | year = 2013 | doi = 10.3904/kjim.2013.28.4.486 | PMID = 23864808 }}</ref>
* [[Zygomycosis]]
 
{{col-end}}
 


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}


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[[Category:Disease]]
[[Category:Disease]]
[[Category:Pulmonology]]
[[Category:Pulmonology]]
[[Category:Infectious disease]]
[[Category:Pneumonia|Pneumonia]]
[[Category:Pneumonia|Pneumonia]]
[[Category:Emergency medicine]]
[[Category:Emergency medicine]]
[[Category:primary care]]

Latest revision as of 21:01, 29 July 2020

Pneumonia Main Page

Community-Acquired Pneumonia Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Chetan Lokhande, M.B.B.S [2]; Alejandro Lemor, M.D. [3]

Overview

Community-acquired pneumonia can be caused by viral, bacterial, and fungal organisms. Causative etiology varies with age, immune status, epidemiologic background, and comorbidity. The most common cause of CAP in adult outpatients and inpatients is Streptococcus pneumoniae. Patients admitted to the intensive care unit tend to have more aggressive organisms such as Staphylococcus aureus and Gram-negative bacilli. Neonates are most susceptible to Group-B-Streptococcus (GBS) which causes approximately 50% of pneumonias in the first week of life. Children and elderly patients are more susceptible to viral infections as well atypical bacterial pneumonias (Mycoplasma, Chlamydia, Legionella).

Causes

Most Common Etiologies for Community-Acquired Pneumonia [1][2][3]
Outpatient Inpatient (non-ICU) Inpatient (ICU)
  1. Streptococcus pneumoniae
  2. Mycoplasma pneumoniae
  3. Haemophilus influenzae
  4. Chlamydophila pneumoniae
  5. Influenza A and B, adenovirus, respiratory syncytial virus, parainfluenza
  1. Streptococcus pneumoniae
  2. Mycoplasma pneumoniae
  3. Haemophilus influenzae
  4. Legionella
  5. Aspiration
  6. Influenza A and B, adenovirus, respiratory syncytial virus, parainfluenza
  7. Yersinia enterocolitica
  1. Streptococcus pneumoniae
  2. Staphylococcus aureus
  3. Legionella
  4. Gram-negative bacilli
  5. Haemophilus influenzae
  6. Acinetobacter baumannii

Common Causes by Age Group
Age Group Neonates Children Adults
Bacteria
  1. Listeria monocytogenes
  2. Mycobacterium tuberculosis
  1. Mycoplasma pneumoniae
  2. Chlamydophila pneumoniae
  3. Legionella pneumophila
  4. Chlamydia trachomatis

Typical Bacteria

  1. Streptococcus pneumoniae
  2. Haemophilus influenzae
  3. Escherichia coli
  4. Klebsiella pneumoniae
  5. Pseudomonas aeruginosa

Atypical Bacteria

  1. Mycoplasma pneumoniae
  2. Chlamydophila pneumoniae
  3. Legionella pneumophila
Virus
  1. Herpes simplex virus
  2. Adenovirus
  3. Mumps
  4. Enterovirus
  1. Respiratory syncytial virus (RSV)
  2. Metapneumovirus
  3. Adenovirus
  4. Parainfluenza
  5. Influenza
  6. Rhinovirus
  1. Influenza
  2. Parainfluenza
  3. Respiratory syncytial virus (RSV)
  4. Metapneumovirus
  5. Adenovirus
  • Newborn infants, children, and adults are at risk for different spectrums of disease causing microorganisms.
  • In addition, adults with chronic illnesses, who live in certain parts of the world, who reside in nursing homes, who have recently been treated with antibiotics, or who are alcoholics are at risk for unique infections.

Infants and Newborns

Children

Adults

The causes of CAP in adults are outlined in the following categories.

Viruses
Streptococcus pneumoniae
  • Streptococcus pneumoniae is the most common cause of community-acquired pneumonia.
  • Aspiration pneumonia is most commonly caused by anaerobic organisms.
  • Prior to the development of antibiotics and vaccination, it was a leading cause of death.
  • Traditionally, it was highly sensitive to penicillin, but during the 1970s resistance to multiple antibiotics began to develop.
  • Current strains of drug resistant Streptococcus pneumoniae (DRSP) are common, accounting for twenty percent of all streptococcal infections.
  • risk factors for DRSP in adults include: being older than 65, having exposure to children in day care, alcoholism, other severe underlying disease, or recent treatment with antibiotics; individuals exposed to these risk factors should initially be treated with antibiotics effective against DRSP.[8]
Atypical Organisms
  • Mycoplasma pneumoniae is often referred to as "walking pneumonia." It is transmitted via respiratory droplets and is common among healthy individuals in close contact with one another in settings such as dormitories or military barracks.
  • Atypical organisms are more difficult to grow and respond to different antibiotics; they were discovered more recently than the typical bacteria discovered in the early twentieth century.
Haemophilus influenzae
  • Haemophilus influenzae used to be a common bacterial cause of CAP.
  • First discovered in 1892, it was initially believed to be the cause of influenza because it commonly causes CAP in people who have suffered recent lung damage from viral pneumonia.
Enteric Gram-Negative Bacteria
  • Enteric bacteria such as Escherichia coli and Klebsiella pneumoniae may cause commnity-acquired penumonia.
  • risk factors in adults for infection include: living in a nursing home, serious heart and lung disease, and recent antibiotic use; these individuals should initially be treated with antibiotics effective against enteric Gram-negative bacteria.
Pseudomonas aeruginosa
Special Situations
Aspiration Pneumonia

Causes by Organ System

Cardiovascular No underlying causes
Chemical/Poisoning No underlying cause
Dental No underlying causes
Dermatologic No underlying causes
Drug Side Effect No underlying cause
Ear Nose Throat No underlying causes
Endocrine No underlying causes
Environmental No underlying cause
Gastroenterologic No underlying cause
Genetic No underlying cause
Hematologic No underlying causes
Iatrogenic No underlying cause
Infectious Disease Acinetobacter baumannii, Actinomycosis, Adenovirus (serotype 1, 2, 3, 4, 5, 7, 14, 21, 35), AIDS-related opportunistic infections, Aspergillosis, Aspiration, Bacillus anthracis, Bird flu (avian influenza), Blastomycosis, Burkholderia cepacia, Burkholderia pseudomallei, Chlamydophila pneumoniae, Chickenpox, Coccidioides immitis, Coronavirus, Coxiella burnetii (Q fever), Cryptococcus neoformans, Cytomegalovirus, Escherichia coli, Enterovirus, Francisella tularensis, Gram-negative bacilli, Haemophilus influenzae, H1N1 flu, Hantavirus, Herpes simplex virus, Histoplasma capsulatum, Histoplasmosis, Human bocavirus, Human parechovirus types 1, 2, and 3, Influenza, Klebsiella pneumoniae, Legionella micdadei, Legionella pneumophila (Legionnaires' disease), Listeria monocytogenes, Mycoplasma pneumoniae, Measles, Melioidosis, Metapneumovirus, Middle East respiratory syndrome coronavirus, Moraxella catarrhalis, Mumps, Mycobacterium avium-intracellulare, Mycobacterium haemophilum, Mycobacterium kansasii, Neisseria meningitidis, New Haven coronavirus, Nocardia, Paragonimiasis, Parainfluenza, Pneumocystis jiroveci, Pneumonic plague, Proteus, Pseudomonas aeruginosa, Chlamydophila psittaci (psittacosis), Rat-bite fever, Respiratory syncytial virus (RSV), Rhinovirus, Rhodococcus equi, Streptococcus pneumoniae (pneumococcus), SARS, Serratia, Severe acute respiratory syndrome, Sporotrichosis , Staphylococcus aureus, Streptococcus agalactiae (group B streptococcus), Streptococcus pyogenes (group A streptococcus), Streptococcus pneumoniae, Swine flu, Toxocariasis , Toxoplasma gondii, Trichosporon , Trypanosomiasis, Typhus, Varicella-zoster virus, Yersinia enterocolitica, Yersinia pestis, Zygomycosis
Musculoskeletal/Orthopedic No underlying causes
Neurologic No underlying causes
Nutritional/Metabolic No underlying cause
Obstetric/Gynecologic No underlying causes
Oncologic No underlying cause
Ophthalmologic No underlying causes
Overdose/Toxicity No underlying cause
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal/Electrolyte No underlying causes
Rheumatology/Immunology/Allergy No underlying cause
Sexual No underlying causes
Trauma No underlying causes
Urologic No underlying causes
Miscellaneous No underlying cause

Causes in Alphabetical Order


References

  1. ↑ Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG (2007). "Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults". Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America. 44 Suppl 2: S27–72. doi:10.1086/511159. PMID 17278083. Retrieved 2012-09-06. Unknown parameter |month= ignored (help)
  2. ↑ Wong, KK.; Fistek, M.; Watkins, RR. (2013). "Community-acquired pneumonia caused by Yersinia enterocolitica in an immunocompetent patient". J Med Microbiol. 62 (Pt 4): 650–1. doi:10.1099/jmm.0.053488-0. PMID 23242642. Unknown parameter |month= ignored (help)
  3. ↑ Oh, YJ.; Song, SH.; Baik, SH.; Lee, HH.; Han, IM.; Oh, DH. (2013). "A case of fulminant community-acquired Acinetobacter baumannii pneumonia in Korea". Korean J Intern Med. 28 (4): 486–90. doi:10.3904/kjim.2013.28.4.486. PMID 23864808. Unknown parameter |month= ignored (help)
  4. ↑ Shachor-Meyouhas, Y.; Arad-Cohen, N.; Zaidman, I.; Gefen, A.; Kassis, I. (2012). "[Legionella pneumonia in a child with leukemia]". Harefuah. 151 (8): 479–82, 496. PMID 23350295. Unknown parameter |month= ignored (help)
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