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| __NOTOC__
| | #REDIRECT [[Azilsartan kamedoxomil#Drug Interactions]] |
| {{Azilsartan}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Drug Interactions==
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| No clinically significant drug interactions have been observed in studies of azilsartan medoxomil or azilsartan given with [[amlodipine]], [[antacids]], [[chlorthalidone]], [[digoxin]], [[fluconazole]], [[glyburide]], [[ketoconazole]], [[metformin]], [[pioglitazone]], and [[warfarin]]. Therefore, Edarbi may be used concomitantly with these medications.
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| ===Non-steroidal Anti-Inflammatory Agents, including Selective Cyclooxygenase-2 Inhibitors (COX-2 Inhibitors)===
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| In patients who are elderly, volume-depleted (including those on diuretic therapy), or who have compromised renal function, coadministration of NSAIDs, including selective COX-2 inhibitors, with angiotensin II receptor antagonists, including azilsartan, may result in deterioration of renal function, including possible acute renal failure. These effects are usually reversible. Monitor renal function periodically in patients receiving azilsartan and [[NSAID]] therapy.
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| The antihypertensive effect of angiotensin II receptor antagonists, including azilsartan, may be attenuated by [[NSAIDs]], including selective COX-2 inhibitors.
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| ===Dual Blockade of the Renin-Angiotensin System (RAS)===
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| Dual blockade of the RAS with angiotensin receptor blockers, ACE inhibitors, or aliskiren is associated with increased risks of [[hypotension]], [[hyperkalemia]], and changes in renal function (including acute renal failure) compared to monotherapy. Closely monitor blood pressure, renal function and electrolytes in patients on Edarbi and other agents that affect the RAS.
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| Do not coadminister aliskiren with Edarbi in patients with diabetes. Avoid use of aliskiren with Edarbi in patients with renal impairment (GFR <60 mL/min).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = EDARBI (AZILSARTAN KAMEDOXOMIL) TABLET [TAKEDA PHARMACEUTICALS AMERICA, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=75b16bfc-38c1-4133-bd7d-13258d54edec | publisher = | date = | accessdate = 19 February 2014 }}</ref>
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| ==References==
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| {{Reflist}}
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| [[Category:Angiotensin II receptor antagonists]]
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| [[Category:Benzimidazoles]]
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| [[Category:Carbamates]]
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| [[Category:Ethers]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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