Delirium future or investigational therapies: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| (18 intermediate revisions by 2 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Delirium}} | {{Delirium}} | ||
{{CMG}}; {{AE}} {{PB}} | {{CMG}}; {{AE}} {{Sara.Zand}} {{PB}} | ||
==Overview== | ==Overview== | ||
There are many still unknowns about delirium. Studies are being conducted to understand pathophysiology, more effective ways of prevention, utilization of EEG and CT/MRI scan, etc. | |||
==Future or Investigational Therapies== | |||
Currently many studies are being conducted such as; | |||
===Prevention of [[Delirium]]=== | |||
*[[ Melatonin]]<ref name="GroverDua2019">{{cite journal|last1=Grover|first1=Sandeep|last2=Dua|first2=Devakshi|last3=Sahoo|first3=Swapnajeet|last4=Chakrabarti|first4=Subho|last5=Avasthi|first5=Ajit|title=Effectiveness of melatonin in the management of delirium: A retrospective study|journal=Journal of Mental Health and Human Behaviour|volume=24|issue=2|year=2019|pages=78|issn=0971-8990|doi=10.4103/jmhhb.jmhhb_56_19}}</ref> | |||
* [[Ramelteon]]<ref name="NishikimiNumaguchi2018">{{cite journal|last1=Nishikimi|first1=Mitsuaki|last2=Numaguchi|first2=Atsushi|last3=Takahashi|first3=Kunihiko|last4=Miyagawa|first4=Yasuhiro|last5=Matsui|first5=Kota|last6=Higashi|first6=Michiko|last7=Makishi|first7=Go|last8=Matsui|first8=Shigeyuki|last9=Matsuda|first9=Naoyuki|title=Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU|journal=Critical Care Medicine|volume=46|issue=7|year=2018|pages=1099–1105|issn=0090-3493|doi=10.1097/CCM.0000000000003132}}</ref> | |||
* [[Dexmedetomidine]]<ref name="NgShubash2019">{{cite journal|last1=Ng|first1=K. T.|last2=Shubash|first2=C. J.|last3=Chong|first3=J. S.|title=The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis|journal=Anaesthesia|volume=74|issue=3|year=2019|pages=380–392|issn=00032409|doi=10.1111/anae.14472}}</ref> | |||
===Studies to Improve Diagnosis and Prevention of [[Delirium]]=== | |||
* Transcranial doppler <ref name="SohShim2019">{{cite journal|last1=Soh|first1=Sarah|last2=Shim|first2=Jae-Kwang|last3=Song|first3=Jong-Wook|last4=Choi|first4=Nakcheoul|last5=Kwak|first5=Young-Lan|title=Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case–control study|journal=Journal of Clinical Monitoring and Computing|volume=34|issue=4|year=2019|pages=715–723|issn=1387-1307|doi=10.1007/s10877-019-00385-x}}</ref> | |||
* [[MRI]]<ref name="NitchinghamKumar2018">{{cite journal|last1=Nitchingham|first1=Anita|last2=Kumar|first2=Varun|last3=Shenkin|first3=Susan|last4=Ferguson|first4=Karen J.|last5=Caplan|first5=Gideon A.|title=A systematic review of neuroimaging in delirium: predictors, correlates and consequences|journal=International Journal of Geriatric Psychiatry|volume=33|issue=11|year=2018|pages=1458–1478|issn=08856230|doi=10.1002/gps.4724}}</ref> | |||
*[[EEG]]<ref name="KimchiNeelagiri2019">{{cite journal|last1=Kimchi|first1=Eyal Y.|last2=Neelagiri|first2=Anudeepthi|last3=Whitt|first3=Wade|last4=Sagi|first4=Avinash Rao|last5=Ryan|first5=Sophia L.|last6=Gadbois|first6=Greta|last7=Groothuysen|first7=Daniël|last8=Westover|first8=M. Brandon|title=Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes|journal=Neurology|volume=93|issue=13|year=2019|pages=e1260–e1271|issn=0028-3878|doi=10.1212/WNL.0000000000008164}}</ref> | |||
===Studies to Understand Pathophysiology of [[Delirium]]=== | |||
* Role of the [[immune system]]<ref name="WangVelagapudi2020">{{cite journal|last1=Wang|first1=Ping|last2=Velagapudi|first2=Ravikanth|last3=Kong|first3=Cuicui|last4=Rodriguiz|first4=Ramona M.|last5=Wetsel|first5=William C.|last6=Yang|first6=Ting|last7=Berger|first7=Miles|last8=Gelbard|first8=Harris A.|last9=Colton|first9=Carol A.|last10=Terrando|first10=Niccolò|title=Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia|journal=Alzheimer's & Dementia|volume=16|issue=5|year=2020|pages=734–749|issn=1552-5260|doi=10.1002/alz.12064}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 13:03, 21 April 2021
|
Delirium Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Delirium On the Web |
|
American Roentgen Ray Society Images of Delirium |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sara Zand, M.D.[2] Pratik Bahekar, MBBS [3]
Overview
There are many still unknowns about delirium. Studies are being conducted to understand pathophysiology, more effective ways of prevention, utilization of EEG and CT/MRI scan, etc.
Future or Investigational Therapies
Currently many studies are being conducted such as;
Prevention of Delirium
Studies to Improve Diagnosis and Prevention of Delirium
Studies to Understand Pathophysiology of Delirium
- Role of the immune system[7]
References
- ↑ Grover, Sandeep; Dua, Devakshi; Sahoo, Swapnajeet; Chakrabarti, Subho; Avasthi, Ajit (2019). "Effectiveness of melatonin in the management of delirium: A retrospective study". Journal of Mental Health and Human Behaviour. 24 (2): 78. doi:10.4103/jmhhb.jmhhb_56_19. ISSN 0971-8990.
- ↑ Nishikimi, Mitsuaki; Numaguchi, Atsushi; Takahashi, Kunihiko; Miyagawa, Yasuhiro; Matsui, Kota; Higashi, Michiko; Makishi, Go; Matsui, Shigeyuki; Matsuda, Naoyuki (2018). "Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU". Critical Care Medicine. 46 (7): 1099–1105. doi:10.1097/CCM.0000000000003132. ISSN 0090-3493.
- ↑ Ng, K. T.; Shubash, C. J.; Chong, J. S. (2019). "The effect of dexmedetomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis". Anaesthesia. 74 (3): 380–392. doi:10.1111/anae.14472. ISSN 0003-2409.
- ↑ Soh, Sarah; Shim, Jae-Kwang; Song, Jong-Wook; Choi, Nakcheoul; Kwak, Young-Lan (2019). "Preoperative transcranial Doppler and cerebral oximetry as predictors of delirium following valvular heart surgery: a case–control study". Journal of Clinical Monitoring and Computing. 34 (4): 715–723. doi:10.1007/s10877-019-00385-x. ISSN 1387-1307.
- ↑ Nitchingham, Anita; Kumar, Varun; Shenkin, Susan; Ferguson, Karen J.; Caplan, Gideon A. (2018). "A systematic review of neuroimaging in delirium: predictors, correlates and consequences". International Journal of Geriatric Psychiatry. 33 (11): 1458–1478. doi:10.1002/gps.4724. ISSN 0885-6230.
- ↑ Kimchi, Eyal Y.; Neelagiri, Anudeepthi; Whitt, Wade; Sagi, Avinash Rao; Ryan, Sophia L.; Gadbois, Greta; Groothuysen, Daniël; Westover, M. Brandon (2019). "Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes". Neurology. 93 (13): e1260–e1271. doi:10.1212/WNL.0000000000008164. ISSN 0028-3878.
- ↑ Wang, Ping; Velagapudi, Ravikanth; Kong, Cuicui; Rodriguiz, Ramona M.; Wetsel, William C.; Yang, Ting; Berger, Miles; Gelbard, Harris A.; Colton, Carol A.; Terrando, Niccolò (2020). "Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia". Alzheimer's & Dementia. 16 (5): 734–749. doi:10.1002/alz.12064. ISSN 1552-5260.