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| __NOTOC__
| | {{ACM}} {{SemRikken}} |
| {{Migraine}} | |
| {{CMG}} | |
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| ==Overview==
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| Following treatment of an acute migraine, it is important to consider preventive measures. Pharmacotherapy for secondary prevention includes [[NSAID]]s, [[amitryptyline]], [[divalproex sodium]], [[valproic acid]], [[propranolol]], [[timolol]] and [[topiramate]] among others. If the preventive measure is not effective after two to three months, the dose of the medication should be adjusted. If no improvement is noted, another first line therapy or a combination of two first line therapies should be initiated.<ref name="pmid22529202">{{cite journal| author=Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E et al.| title=Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. | journal=Neurology | year= 2012 | volume= 78 | issue= 17 | pages= 1337-45 | pmid=22529202 | doi=10.1212/WNL.0b013e3182535d20 | pmc=PMC3335452 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22529202 }} </ref>
| | ''SANDBOX'' |
| | | [[File:Captura de Pantalla 2024-05-18 a la(s) 9.33.11 p.m..png]] |
| ==Indications for Pharmacologic Prophylaxis of Migraine==
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| According to the guideline from [[American Academy of Neurology|American Academy of Neurology (AAN)]], prophylaxis may be more appropriately guided by one or more of the following:<ref>{{Cite web | last = | first = | title = Evidence-Based Guidelines for Migraine Headache in the Primary Care Setting: Pharmacological Management for Prevention of Migraine | url = http://tools.aan.com/professionals/practice/pdfs/gl0090.pdf | publisher = | date = | accessdate = }}</ref>
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| * Recurring migraines that, in the patients' opinion, significantly interfere with their daily routines, despite acute treatment
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| * Frequent headaches
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| * Contraindication to, failure of, or overuse of acute therapies
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| * Adverse events with acute therapies
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| * The cost of both acute and preventive therapies
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| * Patient preference
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| * The presence of uncommon migraine conditions, including hemiplegic migraine, basilar migraine, migraine with prolonged aura, or migrainous infarction.
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| [[European Federation of Neurological Societies|European Federation of Neurological Societies (EFNS)]] proposed that prophylactic treatment should be considered and discussed with the patient when:<ref name="Evers-2006">{{Cite journal | last1 = Evers | first1 = S. | last2 = Afra | first2 = J. | last3 = Frese | first3 = A. | last4 = Goadsby | first4 = PJ. | last5 = Linde | first5 = M. | last6 = May | first6 = A. | last7 = Sándor | first7 = PS. | title = EFNS guideline on the drug treatment of migraine - report of an EFNS task force. | journal = Eur J Neurol | volume = 13 | issue = 6 | pages = 560-72 | month = Jun | year = 2006 | doi = 10.1111/j.1468-1331.2006.01411.x | PMID = 16796580 }}</ref>
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| * The quality of life, business duties, or school attendance are severely impaired
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| * Frequency of attacks per month is two or higher
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| * Migraine attacks do not respond to acute drug treatment
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| * Frequent, very long, or uncomfortable auras occur
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| United States guidelines recommend to initiate preventive therapy when attacks '''regularly exceed two times per week''', whereas European guidelines suggest migraine prophylaxis for '''two or more attacks per month'''.<ref name="Evers-2006">{{Cite journal | last1 = Evers | first1 = S. | last2 = Afra | first2 = J. | last3 = Frese | first3 = A. | last4 = Goadsby | first4 = PJ. | last5 = Linde | first5 = M. | last6 = May | first6 = A. | last7 = Sándor | first7 = PS. | title = EFNS guideline on the drug treatment of migraine - report of an EFNS task force. | journal = Eur J Neurol | volume = 13 | issue = 6 | pages = 560-72 | month = Jun | year = 2006 | doi = 10.1111/j.1468-1331.2006.01411.x | PMID = 16796580 }}</ref><ref>{{Cite web | last = | first = | title = Evidence-Based Guidelines for Migraine Headache in the Primary Care Setting: Pharmacological Management for Prevention of Migraine | url = http://tools.aan.com/professionals/practice/pdfs/gl0090.pdf | publisher = | date = | accessdate = }}</ref>
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| ==Pharmacological Prevention==
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| The main goal of preventive therapy is to reduce the frequency, severity, and durations of migraines, and to increase the effectiveness of abortive therapy. Another reason is to avoid medication overuse headache (MOH), otherwise known as [[rebound headache]], which is an extremely common problem among migraneurs. This occurs in part due to overuse of pain medications. MOH results in the development of chronic daily headache due to "transformed" migraine. Preventive medication has to be taken on a daily basis, usually for a few weeks, before the effectiveness can be determined. Supervision by a [[neurologist]] is advisable. A large number of medications with varying modes of action can be used. Selection of a suitable medication for any particular patient is a matter of trial and error, since the effectiveness of individual medications varies widely from one patient to the next. Often preventive medications do not have to be taken indefinitely. Sometimes as little as six months of preventive therapy is enough to "break the headache cycle" and then they can be discontinued. The most effective prescription medications include several drug classes:
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| * '''[[Beta blockers]]''' such as [[propranolol]] and [[atenolol]]. A [[meta-analysis]] by the [[Cochrane Collaboration]] of nine [[randomized controlled trials]] or [[crossover studies]], which together included 668 patients, found that [[propranolol]] had an "overall [[relative risk]] of response to treatment (here called the 'responder ratio')" was 1.94.<ref name="pmid15106196">{{cite journal | author = Linde K, Rossnagel K | title = Propranolol for migraine prophylaxis. | journal = Cochrane Database Syst Rev | volume = | issue = | pages = CD003225 | year = | id = PMID 15106196}}</ref>
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| * '''[[Anticonvulsants]]''' such as [[valproic acid]] and [[topiramate]]. A [[meta-analysis]] by the [[Cochrane Collaboration]] of ten [[randomized controlled trials]] or [[crossover studies]], which together included 1341 patients, found [[anticonvulsants]] had an "2.4 times more likely to experience a 50% or greater reduction in frequency with anticonvulsants than with placebo" and a [[number needed to treat]] of 3.8.<ref name="pmid15266476">{{cite journal | author = Chronicle E, Mulleners W | title = Anticonvulsant drugs for migraine prophylaxis. | journal = Cochrane Database Syst Rev | volume = | issue = | pages = CD003226 | year = | id = PMID 15266476}}</ref> However, concerns have been raised about the marketing of [[gabapentin]].<ref name="pmid16908919">{{cite journal | author = Steinman M, Bero L, Chren M, Landefeld C | title = Narrative review: the promotion of gabapentin: an analysis of internal industry documents. | journal = Ann Intern Med | volume = 145 | issue = 4 | pages = 284-93 | year = 2006 | id = PMID 16908919}}</ref>
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| * '''[[Antidepressant]]s''' include [[tricyclic antidepressants]] (TCAs) such as [[amitriptyline]] and the newer [[selective serotonin reuptake inhibitors]] (SSRIs) such as [[fluoxetine]]. A [[meta-analysis]] by the [[Cochrane Collaboration]] found [[selective serotonin reuptake inhibitors]] are no more effective than placebo.<ref name="pmid16034880">{{cite journal | author = Moja P, Cusi C, Sterzi R, Canepari C | title = Selective serotonin re-uptake inhibitors (SSRIs) for preventing migraine and tension-type headaches. | journal = Cochrane Database Syst Rev | volume = | issue = | pages = CD002919 | year = | id = PMID 16034880}}</ref> Another [[meta-analysis]] found benefit from SSRIs among patients with migraine or tension headache; however, the effect of SSRIs on only migraines was not separately reported.<ref name="pmid11448661">{{cite journal | author = Tomkins G, Jackson J, O'Malley P, Balden E, Santoro J | title = Treatment of chronic headache with antidepressants: a meta-analysis. | journal = Am J Med | volume = 111 | issue = 1 | pages = 54-63 | year = 2001 | id = PMID 11448661}}</ref> A [[randomized controlled trial]] found that [[amitriptyline]] was better than placebo and similar to [[propranolol]].<ref name="pmid3579659">{{cite journal | author = Ziegler D, Hurwitz A, Hassanein R, Kodanaz H, Preskorn S, Mason J | title = Migraine prophylaxis. A comparison of propranolol and amitriptyline. | journal = Arch Neurol | volume = 44 | issue = 5 | pages = 486-9 | year = 1987 | id = PMID 3579659}}</ref>
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| Other drugs:
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| * [[Sansert]] was withdrawn from the US market by [[Novartis]], but is available in Canadian pharmacies. Although highly effective, it has rare but serious side effects, including [[retroperitoneal fibrosis]].
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| * [[Namenda]], memantine HCI tablets, which is used in the treatment of Alzheimer's Disease, is beginning to be used off label for the treatment of migraines. It has not yet been approved by the FDA for the treatment of migraines.
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| * [[ASA]] or [[Asprin]] can be taken daily in low doses such as 80 to 81 mg, the blood thinners in ASA has been shown to help some migrainures, especially those who have an aura.
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| ====Migraine Specific Therapies====
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| {| style="border: 2px solid #696969;" align="center"
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| |+ <SMALL>''Classification, Dosage, and Side-Effects of Migraine Preventive Therapies.''<ref name="Silberstein-2012">{{Cite journal | last1 = Silberstein | first1 = SD. | last2 = Holland | first2 = S. | last3 = Freitag | first3 = F. | last4 = Dodick | first4 = DW. | last5 = Argoff | first5 = C. | last6 = Ashman | first6 = E. | title = Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. | journal = Neurology | volume = 78 | issue = 17 | pages = 1337-45 | month = Apr | year = 2012 | doi = 10.1212/WNL.0b013e3182535d20 | PMID = 22529202 }}</ref><ref name="Goadsby-2010">{{Cite journal | last1 = Goadsby | first1 = PJ. | last2 = Sprenger | first2 = T. | title = Current practice and future directions in the prevention and acute management of migraine. | journal = Lancet Neurol | volume = 9 | issue = 3 | pages = 285-98 | month = Mar | year = 2010 | doi = 10.1016/S1474-4422(10)70005-3 | PMID = 20170842 }}</ref></SMALL>
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| | style="background: #A5B2D6; border: 0px solid #696969; padding: 0 5px; width: 10%" | '''Evidence'''
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| | style="background: #A5B2D6; border: 0px solid #696969; padding: 0 5px; width: 15%" | '''Agent'''
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| | style="background: #A5B2D6; border: 0px solid #696969; padding: 0 5px; width: 15%" | '''Dosage'''
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| | style="background: #A5B2D6; border: 0px solid #696969; padding: 0 5px; width: 60%" | '''Potential Side-Effects'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=center rowspan="10" |'''Level A''' <BR> <SMALL> Medications with <BR> established efficacy <BR> (>2 Class I trials) </SMALL>
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Antiepileptic Drugs'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Divalproex sodium]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''250 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Drowsiness, weight gain, tremor, hair loss, fetal abnormalities, hematological or liver abnormalities
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Sodium valproate]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''400–600 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Drowsiness, weight gain, tremor, hair loss, fetal abnormalities, hematological or liver abnormalities
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Topiramate]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''50–200 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Paresthesia, cognitive dysfunction, weight loss, care with a family history of glaucoma, nephrolithiasis
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Beta Blockers'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Metoprolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''25–100 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Reduced energy, tiredness, postural symptoms; contraindicated in asthma
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Propranolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''40–120 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Paresthesias, sleepiness, gastrointestinal intolerance
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Timolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''10 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Reduced energy, tiredness, postural symptoms; contraindicated in asthma
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Triptans''' <SMALL> (short-term prophylaxis of menstrually-related migraine) </SMALL>
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Frovatriptan]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''2.5 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Coronary artery vasospasm, transient myocardial ischemia, myocardial infarction, arrhythmia
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=center rowspan="9" | '''Level B''' <BR> <SMALL> Medications are <BR> probably effective <BR> (1 Class I or <BR> 2 Class II studies) </SMALL>
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Antidepressants/SSRI/SSNRI/TCA'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Amitriptyline]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''25–75 mg every night'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Nausea, vomiting, drowsiness, hypersomnolence, dry mouth, concentration difficulties
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Venlafaxine]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''75–150 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Nausea, vomiting, drowsiness
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Beta Blockers'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Atenolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''50 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Reduced energy, tiredness, postural symptoms; contraindicated in asthma
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Nadolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''80–240 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Reduced energy, tiredness, postural symptoms; contraindicated in asthma
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Triptans''' <SMALL> (short-term prophylaxis of menstrually-related migraine) </SMALL>
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Naratriptan]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''1 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Dizziness, chest pain, malaise
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Zolmitriptan]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''2.5 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Asthenia, headache, dizziness, nausea
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=center rowspan="14" |'''Level C''' <BR> <SMALL> Medications are <BR> possibly effective <BR> (1 Class II study)</SMALL>
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''ACE Inhibitors'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Lisinopril]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''20 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Cough, dizziness
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Angiotensin Receptor Blockers'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Candesartan]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''16 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Birth defects and fetal death
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Alpha Agonists'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Guanfacine]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''1 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Dizziness, drowsiness, headache, constipation, diarrhea, loss of appetite, fatigue, nasal congestion
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Antiepileptic Drugs'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Carbamazepine]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''200 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Drowsiness, motor coordination impairment, upset stomach
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Beta Blockers'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Nebivolol]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''5 mg daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Fatigue, clinical depression, bradycardia, impotence
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Antihistamines'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Cyproheptadine]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''4 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Weight gain, abdominal discomfort, diarrhea, nausea, vomiting, xerostomia, depression, somnolence
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left colspan="3" | '''Calcium Channel Blockers'''
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| | style="font-size: 90%; padding: 0 5px; background: #F5F5F5" align=left | ▸ '''''[[Nicardipine]]'''''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | '''20 mg twice daily'''
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| | style="font-size: 90%; padding: 0 5px; background: #DCDCDC" align=left | Headache, upset stomach, dizziness, fatigue, numbness, palpitations, constipation, heartburn
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| |}
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| ====NSAIDs and Complementary Drugs====
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| Shown below is an image depicting the classification of [[NSAID]]s and complementary drugs for migraine prevention according to the '''American Academy of Neurology''' and the '''American Headache Society'''.<ref name="pmid22529202">{{cite journal| author=Silberstein SD, Holland S, Freitag F, Dodick DW, Argoff C, Ashman E et al.| title=Evidence-based guideline update: pharmacologic treatment for episodic migraine prevention in adults: report of the Quality Standards Subcommittee of the American Academy of Neurology and the American Headache Society. | journal=Neurology | year= 2012 | volume= 78 | issue= 17 | pages= 1337-45 | pmid=22529202 | doi=10.1212/WNL.0b013e3182535d20 | pmc=PMC3335452 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22529202 }} </ref>
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| {|Class="wikitable"
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| | '''Level A'''<br> '''Established efficacy'''
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| | '''Level B''' <br> '''Probable efficacy'''
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| | '''Level C''' <br> '''Possible efficacy'''
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| |'''Petasites'''
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| *50 - 300mg BID <br>
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| *2.08 - 18.75 TID for MIG-99 preparation
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| |'''[[NSAID]]s'''
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| *[[Fenoprofen]]
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| **200 - 600mg
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| *[[Ibuprofen]]
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| **200mg twice a day
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| *[[Ketoprofen]]
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| **300mg three times a day
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| *[[Naproxen]]
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| **500 - 1100mg
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| *[[Naproxen sodium]]
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| **550mg twice a day
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| <br>
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| <br>
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| '''[[Histamine]]s'''
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| *[[Histamine]] SQ
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| **1 - 10ng twice a week
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| <br>
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| <br>
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| '''[[Vitamin]]s and [[Mineral]]s'''
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| *[[Riboflavin]]
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| **400mg per day
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| *[[Magnesium]]
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| **600mg per day
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| | '''[[NSAID]]s'''
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| * [[Flurbiprofen]]
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| * [[Mefenamic acid]]
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| <br>
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| <br>
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| '''Herbal therapies, vitamins, and minerals'''
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| * Co-Q10
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| * [[Estrogen]]
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| <br>
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| <br>
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| '''[[Antihistamines]]'''
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| *Cyproheptadine
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| |-
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| |}
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| ==Non Pharmacological Prevention==
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| ====Physical Therapy====
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| Many physicians believe that [[exercise]] for 15-20 minutes per day is helpful for reducing the frequency of migraines.<ref>http://www.headachedrugs.com/pdf/HA2005.pdf] (PDF)</ref> [[Massage]] therapy and [[physical therapy]] are often very effective forms of treatment to reduce the frequency and intensity of migraines. However, it is important to be treated by a well-trained therapist who understands the pathophysiology of migraines. Deep massage can 'trigger' a migraine attack in a person who is not used to such treatments. It is advisable to start sessions as short in duration and then work up to longer treatments.Frequent migraines can leave the sufferer with a stiff neck which can cause stress headaches that can then exacerbate the migraines. Claims have been made that myofascial release can relieve this tension and in doing so reduce or eliminate the stress headache element.
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| ====Prism Eyeglasses====
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| Two studies have shown a relationship between the use of eyeglasses containing prisms and a reduction in migraine headaches. Turville, A. E. (1934) "Refraction and migraine". ''Br. J. Physiol. Opt.'' 8, 62–89, contains a review of the literature and theories existing in 1934, and includes the vascular theory of migraine, which is popular today. In that study, Turville suggests that many patients were provided with complete relief from migraine symptoms with proper eyeglass prescriptions, which included prescribed prism. Most optometrists avoid prescribing prism because, when incorrectly prescribed, it can cause headaches.
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| ====Herbal and Nutritional Supplements====
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| It was shown in a controlled trial that 50 mg or 75 mg/day of [[butterbur]] (''Petasites hybridus'') rhizome extract was asoociated 50% or more reduction in the number of migraines to 68% of participants in the 75 mg dose group, 56% in the 50 mg dose group and 49% in the placebo group after four months. Native butterbur contains some carcinogenic compounds, but a purified version, Petadolex®, does not.
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| [[Cannabis]] was a standard treatment for migraines from the mid-19th century until it was outlawed in the early 20th century in the USA. It has been reported to help relieve the [[nausea]] and dull the head pain, as well as to possibly prevent the headache completely when used as soon as possible after the onset of pre-migraine symptoms, such as aura. There is some indication that semi-regular use may reduce the frequency of attacks. Further studies are being conducted. Some migraine sufferers report that cannabis increases throbbing and pain, especially if smoked. A pharmaceutical company is currently conducting trials of a whole cannabis extract spray for migraine.
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| Supplementation of [[coenzyme Q10]] has been found to have a beneficial effect on the condition of some sufferers of migraines. In an [[open-label trial]],<ref name="CoenzymeRozen">{{cite journal | author = Rozen T, Oshinsky M, Gebeline C, Bradley K, Young W, Shechter A, Silberstein S | title = Open label trial of coenzyme Q10 as a migraine preventive. | journal = Cephalalgia | volume = 22 | issue = 2 | pages = 137-41 | year = 2002 | id = PMID 11972582}}</ref> Young and Silberstein found that 61.3% of patients treated at a dose of 100 mg/day had a greater than 50% reduction in number of days with migraine, making it more effective than most prescription prophylactics. Fewer than 1% reported any side effects. A double-blind placebo-controlled trial has also found positive results.<ref>{{cite journal |author=Sándor PS, et al.|title=Efficacy of coenzyme Q10 in migraine prophylaxis: A randomized controlled trial |journal=Neurology |volume=64 |pages=713-715 |year=2005 |url = http://www.neurology.org/cgi/content/abstract/64/4/713}}</ref>
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| The plant [[feverfew]] (''Tanacetum parthenium'') is a traditional herbal remedy believed to reduce the frequency of migraine attacks. Clinical trials have been carried out, and appear to confirm that the effect is genuine (though it does not completely prevent attacks).<ref name="Diener-2005">{{Cite journal | last1 = Diener | first1 = HC. | last2 = Pfaffenrath | first2 = V. | last3 = Schnitker | first3 = J. | last4 = Friede | first4 = M. | last5 = Henneicke-von Zepelin | first5 = HH. | title = Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention--a randomized, double-blind, multicentre, placebo-controlled study. | journal = Cephalalgia | volume = 25 | issue = 11 | pages = 1031-41 | month = Nov | year = 2005 | doi = 10.1111/j.1468-2982.2005.00950.x | PMID = 16232154 }}</ref>
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| [[Kudzu]] root (''Pueraria lobata'') has been demonstrated to help with menstrual migraine headaches and [[cluster headaches]]. While the studies on menstrual migraine assumed that kudzu acted by imitating estrogen, it has since been shown that kudzu has significant effects on the serotonin receptors.
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| [[Magnesium citrate]] has reduced the frequency of migraine in an experiment in which the magnesium citrate group received 600 mg per day oral of trimagnesium dicitrate. In weeks 9-12, the frequency of attacks was reduced by 41.6% in the magnesium citrate group and by 15.8% in the placebo group.<ref name="MagesiumPeikert">{{cite journal | author = Peikert A, Wilimzig C, Köhne-Volland R | title = Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. | journal = Cephalalgia | volume = 16 | issue = 4 | pages = 257-63 | year = 1996 | id = PMID 8792038}}</ref>
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| Supplemental [[riboflavin]] or [[Vitamin B2]] has also been used, often with magnesium citrate, to reduce the number of migraines. Its effectiveness is less well documented.
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| ====Non-Drug Medical Treatments====
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| [[Botulin toxin|Botox]] is being used by many headache specialists for patients with frequent or chronic migraines with encouraging results.<ref>Samton JB and Mauskop A. The treatment of headaches with Botulinum Toxin. Expert Review of Neurotherapeutics March 2006, Vol. 6, No. 3, Pages 313-322. </ref> [[Spinal Cord Stimulator|Spinal cord stimulator]]s are an implanted medical device sometimes used for those who suffer severe migraines several days each month.<ref name="SCSMatharu">{{cite journal | author=Matharu MS, Bartsch T, Ward N, Frackowiak RS, Weiner R, Goadsby PJ | title=Central neuromodulation in chronic migraine patients with suboccipital stimulators: a PET study | journal=Brain | year=2004 | pages=220-30 | volume=127 | issue=Pt 1 | id=PMID 14607792}}</ref> [[Transcranial magnetic stimulation|Transcranial Magnetic Stimulation]] (TMS), a medically non-invasive technology for treating depression, [[obsessive compulsive disorder]] and [[tinnitus]], among other ailments — helped to prevent and even reduce the severity of migraines among patients.<ref name="urlThe Ohio State University Wexner Medical Center">{{cite web |url=http://medicalcenter.osu.edu/ |title=The Ohio State University Wexner Medical Center |format= |work= |accessdate=2012-08-30}}</ref> This treatment essentially disrupts the aura phase of migraines before patients develop full-blown migraines.<ref name="urlTechnology | The Times">{{cite web |url=http://technology.timesonline.co.uk/article/0,,20409-2237003.html |title=Technology | The Times |format= |work= |accessdate=2012-08-30}}</ref> In about 74% of the migraine headaches, TMS was found to eliminate or reduce nausea and sensitivity to noise and light. Their research suggests that there is a strong neurological component to migraines. A larger study will be conducted soon to better assess TMS's complete effectiveness.<ref name="TMSMohammad">{{cite conference | first = Yousef | last = Mohammad | title = Magnets Zap Migraines | booktitle = 49th Annual Scientific Meeting of the [[American Headache Society]] | date = [[2006-06-22]] | location = [[Los Angeles]], [[California]] | url = http://researchnews.osu.edu/archive/headzap.htm | accessdate = 2006-07-04 }}</ref>
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| ====Alternatives====
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| Because the conventional approaches to migraine prevention are not 100% effective and can have unpleasant side effects, many seek alternative treatments. Some migraine sufferers find relief through [[acupuncture]], which is usually used to help prevent headaches from developing. Sometimes acupuncture is used to relieve the pain of an active migraine headache. In one controlled trial of acupuncture with a sham control in migraine, the acupuncture was not more effective than the sham acupuncture but was more effective than delayed acupuncture. Additionally [[acupressure]] is used by some for relief. For instance pressure between the thumbs and index finger to help subside headaches if the headache or migraine isn't too severe.Incense and scents are shown to help. The smell and incense of peppermint and lavender have been proven to help with migraines and headaches more so than most other scents.
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| [[Biofeedback]] has been used successfully by some to control migraine symptoms through training and practice. There is evidence that [[Magnesium in biological systems|magnesium]] supplements can reduce the frequency of migraine headaches. Riboflavin (vitamin B2), co-enzyme Q10 and butterbur extract has been also subjected to double-blind studies suggesting their efficacy in preventing migraine headaches.
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| Sleep is often a good solution if a migraine is not so severe as to prevent it, as when a person awakes the symptoms will have most likely subsided. [[Diet (nutrition)|Diet]], [[visualization (cam)|visualization]], and [[self-hypnosis]] are also alternative treatments and prevention approaches. [[Bruxism]], clenching or grinding of teeth, especially at night, is a trigger for many migraineurs.
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| A device called a nociceptive trigeminal inhibitor (NTI) takes advantage of a reflex limiting the force of clenching. It can be fitted by dentists and clips over the front teeth at night, preventing contact between the back teeth. It has a success rate similar to butterbur and co-enzyme Q10, although it has not been subjected to the same rigorous testing as the supplements.
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| Massage therapy of the jaw area can also reduce such pain. [[Sexual activity]] has been reported by a proportion of male and female migraine sufferers to relieve migraine pain significantly in some cases. In many cases where a migraine follows a particular cycle, attempting to interrupt the cycle may prolong the symptoms. Letting a headache "run its course" by not using painkillers can sometimes decrease the length of an episode. This is especially true of cases where vomiting is common, as often the headache will subside immediately after vomiting. Curbing the pain may delay vomiting, and prolong the headache.
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| ==References==
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| {{reflist|2}}
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| [[Category:Migraine]]
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| [[Category:Primary care]]
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| [[Category:Neurology]]
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| [[Category:Signs and symptoms]]
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| [[Category:Emergency medicine]]
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| [[Category:Disease]]
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| [[Category:Headaches]]
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| [[Category:Head and neck]]
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