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| __NOTOC__
| | #REDIRECT [[Guanfacine#Structure]] |
| {{Guanfacine}}
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| {{CMG}}; {{AE}} {{SS}}
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| ==Description==
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| INTUNIV® is a once-daily, extended-release formulation of guanfacine hydrochloride (HCl) in a matrix tablet formulation for oral administration only. The chemical designation is N-amidino-2-(2,6-dichlorophenyl) acetamide monohydrochloride. The molecular formula is C9H9Cl2 N3O·HCl corresponding to a molecular weight of 282.55. The chemical structure is:
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| |[[File:INTUNIV07.jpg|thumb|800px]]
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| |[[File:INTUNIV08.gif|thumb|800px]]
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| |}Guanfacine HCl is a white to off-white crystalline powder, sparingly soluble in water (approximately 1 mg/mL) and alcohol and slightly soluble in acetone. The only organic solvent in which it has relatively high solubility is methanol (>30 mg/mL). Each tablet contains guanfacine HCl equivalent to 1 mg, 2 mg, 3 mg, or 4 mg of guanfacine base. The tablets also contain hypromellose, methacrylic acid copolymer, lactose, povidone, crospovidone, microcrystalline cellulose, fumaric acid, and glyceryl behenate. In addition, the 3mg and 4mg tablets also contain green pigment blend PB-1763.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = INTUNIV (GUANFACINE) TABLET, EXTENDED RELEASE INTUNIV (GUANFACINE) KIT [SHIRE US MANUFACTURING INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b972af81-3a37-40be-9fe1-3ddf59852528#section-12.1 | publisher = | date = | accessdate = 25 February 2014 }}</ref>
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| ==References==
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| {{reflist|2}}
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| {{Antihypertensives and diuretics}}
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| {{Antihyperkinetics}}
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| {{Adrenergics}}
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| [[Category:Antihypertensive agents]]
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| [[Category:Guanidines]]
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| [[Category:Alpha-adrenergic agonists]]
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| [[Category:Acetamides]]
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| [[Category:Organochlorides]]
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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