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| __NOTOC__
| | #REDIRECT [[Fondaparinux#Drug Interactions]] |
| {{Fondaparinux}}
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| {{CMG}}; {{AE}} {{AZ}}
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| ==Drug Interactions==
| | [[Category: Cardiovascular Drugs]] |
| In clinical studies performed with ARIXTRA:
| | [[Category: Drug]] |
| :*The concomitant use of oral anticoagulants (warfarin), platelet inhibitors ([[acetylsalicylic acid]]), NSAIDs (piroxicam), and digoxin did not significantly affect the pharmacokinetics/pharmacodynamics of fondaparinux sodium. In addition, ARIXTRA neither influenced the pharmacodynamics of [[warfarin]], [[acetylsalicylic acid]], [[piroxicam]], and [[digoxin]], nor the pharmacokinetics of [[digoxin ]]at steady state.
| | [[Category: Anticoagulants]] |
| :*Agents that may enhance the risk of hemorrhage '''should be discontinued''' prior to initiation of therapy with ARIXTRA unless these agents are essential. If co-administration is necessary, '''monitor patients closely for hemorrhage'''. [See[[Fondaparinux warnings and precautions| Warnings and Precautions (5.1)]].] | |
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| In an in vitro study in human liver microsomes:
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| :*Inhibition of [[CYP2A6 ]]hydroxylation of [[coumarin ]]by fondaparinux (200 micromolar i.e., 350 mg/L) was 17 to 28%. Inhibition of the other isozymes evaluated (CYPs 1A2, 2C9, 2C19, 2D6, 3A4, and 3E1) was 0 to 16%.
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| :*Since fondaparinux '''does not markedly inhibit [[CYP450s|CYP450]]''' (CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, or CYP3A4) in vitro, fondaparinux sodium is not expected to significantly interact with other drugs in vivo by inhibition of metabolism mediated by these isozymes.
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| '''Protein-Binding Displacement'''
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| Since fondaparinux sodium does not bind significantly to plasma proteins other than ATIII, '''no drug interactions by protein-binding displacement''' are expected.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = ARIXTRA (FONDAPARINUX SODIUM) INJECTION, SOLUTION [GLAXOSMITHKLINE LLC] | url =http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=05bb2dd4-5fb5-4ec9-29a8-d200e62d1a8f | publisher = | date = | accessdate = }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]] | |
| [[Category:Drugs]] | |