Argatroban nonclinical toxicology: Difference between revisions

Latest revision as of 17:43, 18 August 2015

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-__NOTOC__
+#REDIRECT [[Argatroban#Nonclinical Toxicology]]
-{{Argatroban}}
-{{CMG}}; {{AE}} {{JH}}
-==Nonclinical Toxicology==
+[[Category: Cardiovascular Drugs]]
+[[Category: Drug]]
-====13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility====
+[[Category: Anticoagulants]]
-Carcinogenicity studies with argatroban have not been performed.
-Argatroban was not genotoxic in the Ames test, the Chinese hamster ovary cell (CHO/HGPRT) forward mutation test, the Chinese hamster lung fibroblast chromosome aberration test, the rat hepatocyte, and WI-38 human fetal lung cell unscheduled DNA synthesis (UDS) tests, or the mouse micronucleus test.
-Argatroban at intravenous doses up to 27 mg/kg/day (0.3 times the recommended maximum human dose based on body surface area) had no effect on fertility and reproductive function of male and female rats.<ref name="dailymed.nlm.nih.gov">{{Cite web  | last =  | first =  | title = ARGATROBAN INJECTION, SOLUTION [GLAXOSMITHKLINE LLC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=9c9616c0-a299-4fd5-c8ae-79e6db453595 | publisher =  | date =  | accessdate = }}</ref>
-==Reference==
-{{reflist}}
-{{FDA}}
-[[Category:Cardiovascular Drugs]]
-[[Category:Hematology]]
-[[Category:Drugs]]