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| __NOTOC__
| | #REDIRECT [[Diltiazem#Overdosage]] |
| {{Diltiazem}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==OVERDOSAGE==
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| Overdosage experience is limited. In the event of overdosage or an exaggerated response, appropriate supportive measures should be employed. The following measures may be considered:
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| '''[[Bradycardia]]:''' Administer atropine (0.6 to 1.0 mg). If there is no response to vagal blockade administer isoproterenol cautiously.
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| '''High-degree [[AV Block]]:''' Treat as for [[bradycardia ]]above. Fixed high-degree [[AV block]] should be treated with cardiac pacing.
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| '''[[Cardiac Failure]]:''' Administer [[inotropic ]]agents ([[isoproterenol]], [[dopamine]], or [[dobutamine]]) and [[diuretics]].
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| '''[[Hypotension]]:''' [[Vasopressors ]](eg, [[dopamine ]]or [[levarterenol]] bitartrate).
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| Actual treatment and dosage should depend on the severity of the clinical situation and the judgment and experience of the treating physician.
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| Diltiazem does not appear to be removed by [[peritoneal ]]or [[hemodialysis]]. Limited data suggest that [[plasmapheresis ]]or [[charcoal ]]hemoperfusion may hasten diltiazem elimination following overdose. | |
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| The intravenous LD50's in mice and rats were 60 to 38 mg/kg, respectively. The toxic dose in man is not known.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DILTIAZEM HYDROCHLORIDE INJECTION [AKORN, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=81c5cf23-a6f8-454a-9575-d01edf49ed34 | publisher = | date = | accessdate = 5 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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