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{{Infobox_Disease
__NOTOC__
| Name          = Roseola
'''For patient information click [[Roseola (patient information)|here]]'''
| Image          =
 
| Caption        =
<small>
| DiseasesDB    = 5857
{{Infobox Disease |
| ICD10          = {{ICD10|B|08|2|b|00}}
Name = Roseola |
| ICD9          = {{ICD9|057.8}}
Image = Roseola.jpg |
| ICDO          =  
Caption = Maculopapular rash as seen in an infant. |
| OMIM          =
| MedlinePlus    = 000968
| eMedicineSubj  = emerg
| eMedicineTopic = 400
| eMedicine_mult = {{eMedicine2|derm|378}} {{eMedicine2|ped|998}}
| MeshID        =
}}
}}
</small>
{{Roseola}}
{{CMG}}:{{AE}}{{DAMI}}
{{SK}} Roseola infantum, exanthem subitum, sixth disease, 3 day rash, pseudorubella, exanthem criticum
==[[Roseola overview|Overview]]==
==[[Roseola historical perspective|Historical Perspective]]==
==[[Roseola classification|Classification]]==


{{Taxobox | color=violet
==[[Roseola pathophysiology|Pathophysiology]]==
| name = ''Roseolovirus''
| image = HHV-6 - EM.jpg
| image_caption = Electron micrograph of HHV-6
| virus_group = i
| familia = ''[[Herpesviridae]]''
| genus = '''''Roseolovirus'''''
| subdivision_ranks = species
| subdivision =  
'''''[[Human herpesvirus 6]]''''' (HHV-6)<br/>
'''''[[Human herpesvirus 7]]''''' (HHV-7)
}}
{{SI}}


==Overview==
==[[Roseola causes|Causes]]==
'''[[Exanthem]] subitum''' (meaning ''sudden rash''), also referred to as '''roseola infantum''' (or '''rose rash of infants'''), '''sixth disease''' (as the sixth rash-causing childhood disease) and (confusingly) '''baby measles''', or '''three day fever''', is a benign disease of children, generally under two years old, whose manifestations are usually limited to a transient rash ("exanthem") that occurs following a fever of about three day's duration.


Until recently, its origin was unknown, but it is now known to be caused by two human [[herpesvirus]]es, '''HHV-6''' ([[Human Herpesvirus Six]]) and '''HHV-7''', also called '''''Roseolovirus'''''.
==[[Roseola differential diagnosis|Differentiating Any Disease from other Diseases]]==


==Clinical Features==
==[[Roseola epidemiology and demographics|Epidemiology and Demographics]]==
Typically the disease affects a child between six months and three years of age, and begins with a sudden high [[fever]] of 102-104 degrees Fahrenheit (39-40 degrees Celsius). This can cause, in some cases, febrile convulsions (also known as [[febrile seizure]]s or "fever fits") due to the sudden rise in body temperature, but in many cases the child appears and acts normal. After a few days the fever subsides, and just as the child appears to be recovering, a red rash appears. This usually begins on the trunk, spreading to the limbs but usually not affecting the face. It disappears again in a matter of hours to a day or so. In contrast, a child suffering from [[measles]] would usually appear more infirm, with symptoms of [[conjunctivitis]] and a cough, and their rash would affect the face and last for several days. Liver dysfunction can occur in rare cases, and the rare adult who contracts the disease can show signs of [[mononucleosis]].


==Vaccines and Treatment==
==[[Roseola risk factors|Risk Factors]]==
There is no specific [[vaccine]] against or treatment for exanthem subitum, and most children with the disease are not seriously ill. A child with [[fever]] should be given plenty of fluids to drink, and [[paracetamol]]/[[acetaminophen]] or [[ibuprofen]] to reduce their temperature (but never [[aspirin]], due to the risk of [[Reye's Syndrome]]<ref>[http://www.reyessyndrome.org/aspirin.htm ''What is the role of aspirin?''], reyessyndrome.org</ref>). He or she should also be kept more lightly clothed than normal if he or she is very hot. The rash is not particularly itchy and needs no special lotions or creams.


It is likely that many children acquire exanthem subitum "subclinically"; in other words, they show no outward sign of the disease. Others may be debilitated enough that a doctor's opinion is required to confirm the diagnosis, and particularly to rule out other more serious infections, such as [[meningitis]] or [[measles]]. In case of [[febrile seizure]]s, medical advice is essential.
==[[Roseola screening|Screening]]==


==References==
==[[Roseola natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
<references/>


==External links==
==Diagnosis==
* [http://www.nlm.nih.gov/medlineplus/ency/article/000968.htm MedlinePlus encyclopedia entry] on "roseola"
[[Roseola history and symptoms|History and Symptoms]] | [[Roseola physical examination|Physical Examination]] | [[Roseola laboratory findings|Laboratory Findings]] | [[Roseola chest x ray|X Ray]] | [[Roseola CT|CT]] | [[Roseola MRI|MRI]] | [[Roseola other imaging findings|Other Imaging Findings]] | [[Roseola other diagnostic studies|Other Diagnostic Studies]]
* [http://www.lib.uiowa.edu/hardin/md/roseola.html Links to roseola pictures], Hardin MD/Univ of Iowa
* [http://query.nytimes.com/gst/fullpage.html?sec=health&res=9E0CE7DC1F3AF93AA15756C0A964958260 Newly Found Herpes Virus Is Called Major Cause of Illness in Young], ''New York Times''
* [http://www.hhv-6foundation.org/ HHV-6 Foundation]
* {{DermNet|viral/roseola}}
{{Viral diseases}}
{{Exanthema}}


[[Category:Viral diseases]]
==Treatment==
[[Category:Pediatrics]]
[[Roseola medical therapy|Medical Therapy]] | [[Roseola surgery|Surgery]] | [[Roseola primary prevention|Primary Prevention]] | [[Roseola secondary prevention|Secondary Prevention]] | [[Roseola cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Roseola future or investigational therapies|Future or Investigational Therapies]]
[[Category:Herpesviruses]]


{{jb1}}
==Case Studies==
{{WH}}
[[Roseola case study one|Case #1]]
{{WS}}


[[de:Drei-Tage-Fieber]]
[[Category:Emergency mdicine]]
[[fr:Roséole]]
[[Category:Disease]]
[[it:Sesta malattia]]
[[Category:Up-To-Date]]
[[nl:Zesde ziekte]]
[[Category:Infectious disease]]
[[ja:突発性発疹]]
[[Category:Neurology]]
[[no:Tredagersfeber]]
[[Category:Pediatrics]]
[[pl:Rumień nagły]]
[[Category:Dermatology]]
[[pt:Roséola]]
[[fi:Vauvarokko]]

Latest revision as of 00:02, 30 July 2020

For patient information click here

Roseola
Maculopapular rash as seen in an infant.

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Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Roseola from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Chest X Ray

CT

MRI

Echocardiography or Ultrasound

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]:Associate Editor(s)-in-Chief: Omodamola Aje B.Sc, M.D. [2]

Synonyms and keywords: Roseola infantum, exanthem subitum, sixth disease, 3 day rash, pseudorubella, exanthem criticum

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Any Disease from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | X Ray | CT | MRI | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1