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| __NOTOC__
| | #REDIRECT [[Methyldopa#Adverse Reactions]] |
| {{Methyldopa}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==Adverse Reactions==
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| [[Sedation]], usually transient, may occur during the initial period of therapy or whenever the dose is increased. [[Headache]], [[asthenia]], or weakness may be noted as early and transient symptoms. However, significant adverse effects due to methyldopa have been infrequent and this agent usually is well tolerated.
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| The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.
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| '''Cardiovascular:''' Aggravation of [[angina pectoris]], [[congestive heart failure]], prolonged [[carotid sinus hypersensitivity]], [[orthostatic hypotension]] (decrease daily dosage), [[edema ]]or weight gain, [[bradycardia]].
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| '''Digestive:''' [[Pancreatitis]], [[colitis]], [[vomiting]], [[diarrhea]], [[sialadenitis]], [[sore ]]or black tongue, [[nausea]], [[constipation]], [[distension]], flatus, dryness of mouth.
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| '''Endocrine:''' [[Hyperprolactinemia]].
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| '''Hematologic:''' [[Bone marrow depression]], [[leukopenia]], [[granulocytopenia]], [[thrombocytopenia]], [[hemolytic anemia]]; positive tests for antinuclear antibody, LE cells, and [[rheumatoid factor]], positive [[Coombs test]].
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| '''Hepatic:''' Liver disorders including [[hepatitis]], [[jaundice]], abnormal liver function tests (see [[Methyldopa injection warnings|WARNINGS]]).
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| '''Hypersensitivity:''' [[Myocarditis]], [[pericarditis]], [[vasculitis]], lupus-like syndrome, drug-related fever, [[eosinophilia]].
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| '''Nervous System/Psychiatric:''' [[Parkinsonism]], [[Bell's palsy]], decreased mental acuity, involuntary choreoathetotic movements, symptoms of cerebrovascular insufficiency, psychic disturbances including [[nightmares ]]and reversible mild [[psychoses ]]or [[depression]], [[headache]], [[sedation]], [[asthenia ]]or [[weakness]], [[dizziness]], light-headedness, [[paresthesias]].
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| '''Metabolic:''' Rise in [[BUN]].
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| '''Musculoskeletal:''' [[Arthralgia]], with or without joint swelling; [[myalgia]].
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| '''Respiratory:''' Nasal [[stuffiness]].
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| '''Skin:''' [[Toxic epidermal necrolysis]], [[rash]].
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| '''Urogenital:''' [[Amenorrhea]], breast enlargement, [[gynecomastia]], [[lactation]], [[impotence]], decreased [[libido]].<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = METHYLDOPATE HYDROCHLORIDE INJECTION, SOLUTION [AMERICAN REGENT, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=f5f25053-a9f3-48b9-a412-078f5ee942fd | publisher = | date = | accessdate = 10 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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