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| __NOTOC__
| | #REDIRECT [[Reserpine#Overdosage]] |
| {{Reserpine}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==Overdosage==
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| ===Acute Toxicity===
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| No deaths due to acute poisoning with reserpine have been reported.
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| Highest known doses survived: children, 1000 mg (age and sex not specified); young children, 200 mg (20-month-old boy).
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| Oral LD50's in animals (mg/kg): rat, 2993; mouse, 47 and 500.
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| ====Signs and Symptoms====
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| The clinical picture of acute poisoning is characterized chiefly by signs and symptoms due to the reflex [[parasympathomimetic]] effect of reserpine.
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| Impairment of [[consciousness ]]may occur and may range from drowsiness to [[coma]], depending upon the severity of overdosage. [[Flushing ]]of the [[skin]], conjunctival injection, and pupillary constriction are to be expected. [[Hypotension]], [[hypothermia]], central respiratory depression, and [[bradycardia ]]may develop in cases of severe overdosage. Increased salivary and gastric secretion and [[diarrhea ]]may also occur.
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| ====Treatment====
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| There is no specific antidote.
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| Stomach contents should be evacuated, taking adequate precautions against aspiration and for protection of the airway. Activated [[charcoal ]]slurry should be instilled.
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| The effects of reserpine overdosage should be treated symptomatically. If [[hypotension ]]is severe enough to require treatment with a vasopressor, one having a direct action upon vascular smooth muscle (e.g., [[phenylephrine]], [[levarterenol]], [[metaraminol]]) should be used. Since reserpine is long-acting, the patient should be observed carefully for at least 72 hours, and treatment administered as required.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = RESERPINE TABLET [EON LABS, INC.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=3a4d74d7-2e63-4789-b50e-af17ced92462 | publisher = | date = | accessdate = 7 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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