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| __NOTOC__
| | #REDIRECT [[Doxazosin#Adult Indications and Dosage]] |
| {{Doxazosin}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==Dosage And Administration==
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| DOSAGE MUST BE INDIVIDUALIZED. The initial dosage of doxazosin tablets in patients with [[hypertension ]]and/or [[BPH ]]is 1 mg given once daily in the a.m. or p.m. This starting dose is intended to minimize the frequency of [[postural hypotension]] and first-dose [[syncope ]]associated with doxazosin. Postural effects are most likely to occur between 2 and 6 hours after a dose. Therefore, blood pressure measurements should be taken during this time period after the first dose and with each increase in dose. If doxazosin tablets administration is discontinued for several days, therapy should be restarted using the initial dosing regimen.
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| Concomitant administration of doxazosin with a PDE-5 inhibitor can result in additive blood pressure lowering effects and symptomatic [[hypotension]]; therefore, [[PDE-5 inhibitor]] therapy should be initiated at the lowest dose in patients taking doxazosin.
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| ===A. Benign Prostatic Hyperplasia 1 to 8 mg once daily.===
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| The initial dosage of doxazosin is 1 mg, given once daily in the a.m. or p.m. Depending on the individual patient’s [[urodynamics ]]and [[BPH ]]symptomatology, dosage may then be increased to 2 mg and thereafter to 4 mg and 8 mg once daily, the maximum recommended dose for [[BPH]]. The recommended titration interval is 1 to 2 weeks. Blood pressure should be evaluated routinely in these patients.
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| ===B. Hypertension 1 to 16 mg once daily.===
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| The initial dosage of doxazosin is 1 mg given once daily. Depending on the individual patient’s standing blood pressure response (based on measurements taken at 2 to 6 hours post-dose and 24 hours post-dose), dosage may then be increased to 2 mg and thereafter if necessary to 4 mg, 8 mg and 16 mg to achieve the desired reduction in blood pressure. Increases in dose beyond 4 mg increase the likelihood of excessive postural effects, including [[syncope]], [[postural dizziness]]/[[vertigo ]]and [[postural hypotension]]. At a titrated dose of 16 mg once daily, the frequency of postural effects is about 12% compared to 3% for placebo.<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = DOXAZOSIN TABLET [APOTEX CORP.] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=4fa5c2f7-cda9-56cd-622f-b3d05dc7c94b | publisher = | date = | accessdate = 7 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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