Template:Metoprolol: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
mNo edit summary
No edit summary
 
(31 intermediate revisions by 5 users not shown)
Line 1: Line 1:
{{Drugbox
| verifiedrevid = 459444186
| IUPAC_name = (''RS'')-1-(Isopropylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol
| image = 2000px-Metoprolol structure.svg.png
| drug_name = Metoprolol


<!--Clinical data-->
| tradename = Lopressor, Toprol-xl
| Drugs.com = {{drugs.com|monograph|metoprolol-succinate}}
| MedlinePlus = a682864
| licence_US = Metoprolol
| pregnancy_AU = C
| pregnancy_US = C
| legal_status = Rx-only
| routes_of_administration = Oral, [[Intravenous|IV]]


<!--Pharmacokinetic data-->
| bioavailability = 12%
| metabolism = [[Liver|Hepatic]] via [[CYP2D6]], [[CYP3A4]]
| elimination_half-life = 3-7 hours
| excretion = [[Kidney|Renal]]


<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 51384-51-1
| ATC_prefix = C07
| ATC_suffix = AB02
| PubChem = 4171
| IUPHAR_ligand = 553
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank = DB00264
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4027
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = GEB06NHM23
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D02358
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 6904
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 13


 
<!--Chemical data-->
 
| C=15 | H=25 | N=1 | O=3
{| class="wikitable" style="margin: 0 0 3em 3em; border: 1px solid #696969; float: right; width:20em" cellpadding="0" cellspacing="0";
| molecular_weight = 267.364&nbsp;[[gram|g]]/[[Mole (unit)|mol]]
! style="padding: 0 5px; font-size: 100%; background:#F8F8FF" align=center | '''''[[Metoprolol|{{fontcolor|#6C7B8B|Metoprolol}}]]'''''
| smiles = O(c1ccc(cc1)CCOC)CC(O)CNC(C)C
|-
| InChI = 1/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
! style="padding: 0 5px; font-size: 85%; background:#F5F5F5" align=left | [[Lopressor]]
| InChIKey = IUBSYMUCCVWXPE-UHFFFAOYAN
|-
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor indications and usage|Indications and Usage]]
| StdInChI = 1S/C15H25NO3/c1-12(2)16-10-14(17)11-19-15-6-4-13(5-7-15)8-9-18-3/h4-7,12,14,16-17H,8-11H2,1-3H3
|-
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor dosage and administration|Dosage and Administration]]
| StdInChIKey = IUBSYMUCCVWXPE-UHFFFAOYSA-N
|-
| melting_point = 120
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor contraindications|Contraindications]]
}}
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor warnings and precautions|Warnings and Precautions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor adverse reactions|Adverse Reactions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor drug interactions|Drug Interactions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor use in specific populations|Use in Specific Populations]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor overdosage|Overdosage]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor description|Description]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor clinical pharmacology|Clinical Pharmacology]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor clinical studies|Clinical Studies]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor how supplied storage and handling|How Supplied/Storage and Handling]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor patient counseling information|Patient Counseling Information]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Lopressor labels and packages|Labels and Packages]]
|-
! style="padding: 0 5px; font-size: 85%; background:#F5F5F5" align=left | TOPROL XL<sup>®</sup> FDA Package Insert
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate indications and usage|Indications and Usage]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate dosage and administration|Dosage and Administration]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate contraindications|Contraindications]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate warnings and precautions|Warnings and Precautions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate adverse reactions|Adverse Reactions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate drug interactions|Drug Interactions]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate use in specific populations|Use in Specific Populations]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate overdosage|Overdosage]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate description|Description]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate clinical pharmacology|Clinical Pharmacology]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate clinical studies|Clinical Studies]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate how supplied storage and handling|How Supplied/Storage and Handling]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate patient counseling information|Patient Counseling Information]]
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [[Metoprolol succinate labels and packages|Labels and Packages]]
|-
! style="padding: 0 5px; font-size: 85%; background:#F5F5F5" align=left | Clinical Trials on Metoprolol
|-
! style="font-size: 80%; padding: 0 5px; background: #DCDCDC" align=left | [http://clinicaltrials.gov/search/open/condition={{urlencode:{{#if:{{{1|}}}|{{{1}}}|{{PAGENAME}}}}}} ClinicalTrials.gov]
|-
|}

Latest revision as of 15:36, 21 March 2014

Metoprolol
Clinical data
Trade namesLopressor, Toprol-xl
AHFS/Drugs.comMonograph
MedlinePlusa682864
[[Regulation of therapeutic goods |Template:Engvar data]]
Pregnancy
category
  • AU: C
  • US: C (Risk not ruled out)
Routes of
administration		Oral, IV
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability12%
MetabolismHepatic via CYP2D6, CYP3A4
Elimination half-life3-7 hours
ExcretionRenal
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC15H25NO3
Molar mass267.364 g/mol
3D model (JSmol)
Melting point120 °C (248 °F)
  (verify)
Retrieved from "https://www.wikidoc.org/index.php?title=Template:Metoprolol&oldid=958751"