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| __NOTOC__
| | #REDIRECT [[Prazosin#Adverse Reactions]] |
| {{Prazosin}}
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| {{CMG}}; {{AE}} {{AK}}
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| ==Adverse Reactions==
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| Clinical trials were conducted on more than 900 patients. During these trials and subsequent marketing experience, the most frequent reactions associated with MINIPRESS therapy are: [[dizziness]] 10.3%, [[headache]] 7.8%, [[drowsiness]] 7.6%, lack of energy 6.9%, [[weakness]] 6.5%, [[palpitations]] 5.3%, and [[nausea]] 4.9%. In most instances, side effects have disappeared with continued therapy or have been tolerated with no decrease in dose of drug.
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| Less frequent adverse reactions which are reported to occur in 1–4% of patients are:
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| '''Gastrointestinal:''' [[vomiting]], [[diarrhea]], [[constipation]].
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| '''Cardiovascular:''' [[edema]], [[orthostatic hypotension]], [[dyspnea]], [[syncope]].
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| '''Central Nervous System:''' [[vertigo]], [[depression]], [[nervousness]].
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| '''Dermatologic:''' [[rash]].
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| '''Genitourinary:''' [[urinary frequency]].
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| '''EENT:''' blurred vision, reddened sclera, [[epistaxis]], [[dry mouth]], [[nasal congestion]].
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| In addition, fewer than 1% of patients have reported the following (in some instances, exact causal relationships have not been established):
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| '''Gastrointestinal:''' abdominal discomfort and/or pain, liver function abnormalities, [[pancreatitis]].
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| '''Cardiovascular:''' [[tachycardia]].
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| '''Central Nervous System:''' [[paresthesia]], [[hallucinations]].
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| '''Dermatologic:''' [[pruritus]], [[alopecia]], lichen [[planus]].
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| '''Genitourinary:''' [[incontinence]], [[impotence]], [[priapism]].
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| '''EENT:''' tinnitus.
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| '''Other:''' diaphoresis, fever, positive ANA titer, arthralgia.
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| Single reports of pigmentary mottling and serous [[retinopathy]], and a few reports of cataract development or disappearance have been reported. In these instances, the exact causal relationship has not been established because the baseline observations were frequently inadequate.
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| In more specific[[ slit-lamp]] and funduscopic studies, which included adequate baseline examinations, no drug-related abnormal ophthalmological findings have been reported.
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| Literature reports exist associating MINIPRESS therapy with a worsening of pre-existing [[narcolepsy]]. A causal relationship is uncertain in these cases.
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| In post-marketing experience, the following adverse events have been reported:
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| '''Autonomic Nervous System:''' [[flushing]].
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| '''Body As A Whole:''' [[allergic reaction]], [[asthenia]], [[malaise]], pain.
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| '''Cardiovascular, General:''' [[angina pectoris]], [[hypotension]].
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| '''Endocrine:''' [[gynecomastia]].
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| '''Heart Rate/Rhythm:''' [[bradycardia]].
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| '''Psychiatric:''' [[insomnia]].
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| '''Skin/Appendages:''' [[urticaria]].
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| '''Vascular (Extracardiac):''' [[vasculitis]].
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| '''Vision:''' eye pain.
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| '''Special Senses:''' During [[cataract]] surgery, a variant of small pupil syndrome known as Intraoperative Floppy Iris Syndrome (IFIS) has been reported in association with alpha-1 blocker therapy (see [[Prazosin precautions|PRECAUTIONS]]).<ref name="dailymed.nlm.nih.gov">{{Cite web | last = | first = | title = MINIPRESS (PRAZOSIN HYDROCHLORIDE) CAPSULE [PFIZER LABORATORIES DIV PFIZER INC] | url = http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=36c4da56-502e-4da1-acf7-8e81ee453dcc | publisher = | date = | accessdate = 6 March 2014 }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Cardiovascular Drugs]]
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| [[Category:Drugs]]
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