Sandbox colesevelam

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sheng Shi, M.D. [2]

Synonyms / Brand Names: Welchol tablet

Overview

Sandbox colesevelam is a anti-anginal, antiarrhythmic, beta-adrenergic blocker drug that is FDA approved for the treatment of acute myocardial infarction, angina, and hypertension. There is a Black Box Warning for this drug as shown here. Common adverse reactions include bradyarrhythmia, heart block, heart failure, hypotension, pruritus, rash, constipation, diarrhea, indigestion, nausea, dizziness, fatigue, headache, depression, dyspnea, and wheezing.

Category

Bile Acid Sequestrant

Adult Indications and Dosage of Tablet

• Initial dose (not receiving a diuretic): Lotensin 10 mg PO qd

• Initial dose (concurrent diuretic use): the diuretic should be discontinued 2 to 3 days prior to beginning therapy with Lotensin, if blood pressure is not controlled with Lotensin alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 5 mg Lotensin should be used.

• Maintenance dose: Lotensin 20—40 mg PO qd or Lotensin 10—20 mg PO bid (MAX 80 mg/day)

Adult Indications and Dosage of Tablet, film coated

• Initial dose (not receiving a diuretic): Lotensin 10 mg PO qd

• Initial dose (concurrent diuretic use): the diuretic should be discontinued 2 to 3 days prior to beginning therapy with Lotensin, if blood pressure is not controlled with Lotensin alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 5 mg Lotensin should be used.

• Maintenance dose: Lotensin 20—40 mg PO qd or Lotensin 10—20 mg PO bid (MAX 80 mg/day)