Sandbox/00030: Difference between revisions
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'''[UNDER CONSTRUCTION]''' | |||
{| style="border: 2px solid # | {{Clostridium difficile infection}} | ||
! | ==Medical Therapy== | ||
! | |||
====Principles of Therapy==== | |||
* If a patient has a strong pre-test suspicion for CDI, empiric therapy for CDI should be considered regardless of the laboratory testing result. | |||
:* ''Clostridium difficile'' infection should be suspected in any patient with diarrhea who has received antibiotics within the previous 2 months and/or whose diarrhea began 72 hours or more after hospitalization.<ref name="pmid9149180">Fekety R (1997) [http://www.ncbi.nlm.nih.gov/pubmed/9149180 Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee.] ''Am J Gastroenterol'' 92 (5):739-50. PMID: [http://www.ncbi.nlm.nih.gov/pubmed/9149180]</ref> | |||
====Classification of Disease Severity==== | |||
{| style="border: 2px solid #DCDCDC; font-size: 90%; width: 80%;" | |||
! style="background: #DCDCDC;" | Severity | |||
! style="background: #DCDCDC;" | Definition | |||
|- | |- | ||
! style="background: #F5F5F5; padding: 10px 10px;" | Mild | |||
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI with diarrhea as the only symptom. | |||
|- | |- | ||
! style="background: #F5F5F5; padding: 10px 10px;" | Moderate | |||
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI with diarrhea but without additional symptoms/signs meeting the definition of severe or complicated CDI. | |||
|- | |- | ||
| style="background: # | ! style="background: #F5F5F5; padding: 10px 10px;" | Severe | ||
| style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI that presents with or develops during the course of the disease with hypoalbuminemia (serum albumin < 3 g/dl) '''<u>and</u>''' either of the following: | |||
* A white blood cell (WBC) count ≥15,000 cells/mm<sup>3</sup> | |||
* Abdominal tenderness | |||
|- | |- | ||
| style="background: #F5F5F5; padding: | ! style="background: #F5F5F5; padding: 10px 10px;" | Complicated | ||
* | | style="background: #F5F5F5; padding: 10px 10px;" valign=top | CDI that presents with or develops at least one of the following signs or symptoms: | ||
* | * Admission to intensive care unit | ||
* | * Hypotension with or without required use of vasopressors | ||
* | * Fever ≥38.5°C | ||
* Ileus or significant abdominal distention | |||
* Mental status changes | |||
* WBC ≥35,000 cells/mm<sup>3</sup> or <2,000 cells/mm<sup>3</sup> | |||
* Serum lactate levels >2.2 mmol/l | |||
* Any evidence of end organ failure | |||
|} | |} | ||
==References== | |||
{{reflist|2}} | |||
Latest revision as of 10:49, 5 June 2014
[UNDER CONSTRUCTION]
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C. difficile Infection Microchapters |
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Differentiating Clostridium difficile infectionfrom other Diseases |
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Diagnosis |
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Treatment |
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Case Studies |
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Sandbox/00030 On the Web |
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American Roentgen Ray Society Images of Sandbox/00030 |
Medical Therapy
Principles of Therapy
- If a patient has a strong pre-test suspicion for CDI, empiric therapy for CDI should be considered regardless of the laboratory testing result.
- Clostridium difficile infection should be suspected in any patient with diarrhea who has received antibiotics within the previous 2 months and/or whose diarrhea began 72 hours or more after hospitalization.[1]
Classification of Disease Severity
| Severity | Definition |
|---|---|
| Mild | CDI with diarrhea as the only symptom. |
| Moderate | CDI with diarrhea but without additional symptoms/signs meeting the definition of severe or complicated CDI. |
| Severe | CDI that presents with or develops during the course of the disease with hypoalbuminemia (serum albumin < 3 g/dl) and either of the following:
|
| Complicated | CDI that presents with or develops at least one of the following signs or symptoms:
|
References
- ↑ Fekety R (1997) Guidelines for the diagnosis and management of Clostridium difficile-associated diarrhea and colitis. American College of Gastroenterology, Practice Parameters Committee. Am J Gastroenterol 92 (5):739-50. PMID: [1]