Dengue fever natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
Dengue fever generally lasts a week or more, and can rarely be complicated by bleeding, [[febrile convulsions]] and [[coma]]. The prognosis is good. Dengue fever can be life-threatening in people with chronic diseases such as [[diabetes]] and [[asthma]]. | |||
Dengue fever generally lasts a week or more, and can rarely be complicated by bleeding, [[febrile convulsions]] and [[coma]]. | |||
==Natural History== | ==Natural History== | ||
* Dengue fever generally lasts about six to seven days, with a smaller peak of fever at the trailing end of the fever (the so-called "biphasic pattern"). The [[platelet]] count will drop until the patient's temperature is normal. | * Dengue fever generally lasts about six to seven days, with a smaller peak of fever at the trailing end of the fever (the so-called "biphasic pattern"). The [[platelet]] count will drop until the patient's temperature is normal.<ref name=WHO2009>{{cite web | title = Dengue: guidelines for diagnosis, treatment, prevention and control | url = http://whqlibdoc.who.int/publications/2009/9789241547871_eng.pdf?ua=1 }}</ref> | ||
==Complications== | ==Complications== | ||
Possible complications of Dengue fever include: | Possible complications of Dengue fever include:<ref name="pmid17993365">{{cite journal| author=Halstead SB| title=Dengue. | journal=Lancet | year= 2007 | volume= 370 | issue= 9599 | pages= 1644-52 | pmid=17993365 | doi=10.1016/S0140-6736(07)61687-0 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17993365 }} </ref> | ||
* Acute respiratory failure<ref name="pmid17620647">{{cite journal| author=Wang CC, Liu SF, Liao SC, Lee IK, Liu JW, Lin AS et al.| title=Acute respiratory failure in adult patients with dengue virus infection. | journal=Am J Trop Med Hyg | year= 2007 | volume= 77 | issue= 1 | pages= 151-8 | pmid=17620647 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17620647 }} </ref> | |||
* Bleeding, specially [[upper gastrointestinal bleeding]] | |||
* [[Febrile convulsions]] | * [[Febrile convulsions]] | ||
* Neurological:<ref name="pmid23355928">{{cite journal| author=Puccioni-Sohler M, Orsini M, Soares CN| title=Dengue: a new challenge for neurology. | journal=Neurol Int | year= 2012 | volume= 4 | issue= 3 | pages= e15 | pmid=23355928 | doi=10.4081/ni.2012.e15 | pmc=PMC3555217 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23355928 }} </ref> [[Central nervous system]] [[hemorrhage]], [[coma]], [[encephalitis]], [[encephalomyelitis]], [[Guillain-Barre syndrome]], [[myelitis]], [[neuropathy]] | |||
* Severe [[dehydration]] | * Severe [[dehydration]] | ||
* | * [[Shock]] | ||
==Prognosis== | ==Prognosis== | ||
Although uncomfortable, dengue fever is generally not deadly. | Although uncomfortable, dengue fever is generally not deadly.<ref name=WHO2009>{{cite web | title = Dengue: guidelines for diagnosis, treatment, prevention and control | url = http://whqlibdoc.who.int/publications/2009/9789241547871_eng.pdf?ua=1 }}</ref>. Mortality rates between 0% and 5.4% have been reported.<ref name="pmid11892494">{{cite journal| author=Guzmán MG, Kourí G| title=Dengue: an update. | journal=Lancet Infect Dis | year= 2002 | volume= 2 | issue= 1 | pages= 33-42 | pmid=11892494 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11892494 }} </ref><ref name="pmid16899384">{{cite journal| author=Ong A, Sandar M, Chen MI, Sin LY| title=Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore. | journal=Int J Infect Dis | year= 2007 | volume= 11 | issue= 3 | pages= 263-7 | pmid=16899384 | doi=10.1016/j.ijid.2006.02.012 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16899384 }} </ref> Dengue fever can be life-threatening in people with chronic diseases such as [[diabetes]] and [[asthma]]. | ||
==References== | ==References== | ||
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[[Category:Flaviviruses]] | [[Category:Flaviviruses]] | ||
[[Category:Hemorrhagic fevers]] | [[Category:Hemorrhagic fevers]] | ||
[[Category:Insect-borne diseases]] | [[Category:Insect-borne diseases]] | ||
[[Category:Neglected diseases]] | [[Category:Neglected diseases]] | ||
[[Category:Tropical disease]] | [[Category:Tropical disease]] | ||
[[Category:Viral diseases]] | [[Category:Viral diseases]] | ||
Latest revision as of 17:34, 18 September 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Dengue fever generally lasts a week or more, and can rarely be complicated by bleeding, febrile convulsions and coma. The prognosis is good. Dengue fever can be life-threatening in people with chronic diseases such as diabetes and asthma.
Natural History
- Dengue fever generally lasts about six to seven days, with a smaller peak of fever at the trailing end of the fever (the so-called "biphasic pattern"). The platelet count will drop until the patient's temperature is normal.[1]
Complications
Possible complications of Dengue fever include:[2]
- Acute respiratory failure[3]
- Bleeding, specially upper gastrointestinal bleeding
- Febrile convulsions
- Neurological:[4] Central nervous system hemorrhage, coma, encephalitis, encephalomyelitis, Guillain-Barre syndrome, myelitis, neuropathy
- Severe dehydration
- Shock
Prognosis
Although uncomfortable, dengue fever is generally not deadly.[1]. Mortality rates between 0% and 5.4% have been reported.[5][6] Dengue fever can be life-threatening in people with chronic diseases such as diabetes and asthma.
References
- ↑ 1.0 1.1 "Dengue: guidelines for diagnosis, treatment, prevention and control" (PDF).
- ↑ Halstead SB (2007). "Dengue". Lancet. 370 (9599): 1644–52. doi:10.1016/S0140-6736(07)61687-0. PMID 17993365.
- ↑ Wang CC, Liu SF, Liao SC, Lee IK, Liu JW, Lin AS; et al. (2007). "Acute respiratory failure in adult patients with dengue virus infection". Am J Trop Med Hyg. 77 (1): 151–8. PMID 17620647.
- ↑ Puccioni-Sohler M, Orsini M, Soares CN (2012). "Dengue: a new challenge for neurology". Neurol Int. 4 (3): e15. doi:10.4081/ni.2012.e15. PMC 3555217. PMID 23355928.
- ↑ Guzmán MG, Kourí G (2002). "Dengue: an update". Lancet Infect Dis. 2 (1): 33–42. PMID 11892494.
- ↑ Ong A, Sandar M, Chen MI, Sin LY (2007). "Fatal dengue hemorrhagic fever in adults during a dengue epidemic in Singapore". Int J Infect Dis. 11 (3): 263–7. doi:10.1016/j.ijid.2006.02.012. PMID 16899384.