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| __NOTOC__
| | #REDIRECT [[Smallpox virus]] |
| {{Smallpox}}
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| {{CMG}}; {{AE}} {{JS}}
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| ==Overview==
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| [[Smallpox]] is caused by the [[variola]] virus. | |
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| ==Taxonomy==
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| [[Viruses]]; [[DNA virus|dsDNA]]; [[Poxviridae]]; Chordopoxvirinae; [[Orthopoxvirus]]; Variola vera
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| ==Biology==
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| [[Variola virus]] is a [[orthopoxvirus]], from the family [[Poxviridae]], the largest [[viruses]] to [[infect]] humans. It is a 200-400 nm dsDNA virus, lacking icosahedral symmetry. The other [[viruses]] of the family [[Poxviridae]] include the [[vaccinia]], the [[molluscum contagiosum]], the [[cowpox]] and the [[monkeypox]]. (6) The viral structure includes:
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| * Outer membrane
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| * 2 lateral bodies
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| * 1 dsDNA molecule in its core containing 186,999 base pairs (7), (8), (9)
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| Variola virus genes are similar to the ones of vaccinia virus, which made possible using the vaccinia virus as a vaccine for smallpox virus. (10)
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| There are 2 forms of variola virus:
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| * Variola major
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| * Variola minor
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| Both strains of the virus share a large amount of genome, which leads to the assumption that the difference in virulence resides in alternate gene expression,
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| ==Origin==
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| ==Tropism==
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| ==Natural reservoir==
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| [[Humans]] are the only [[natural reservoir]] of [[smallpox virus]].<ref name=CDC>{{cite web | title = Smallpox disease overview | url = http://www.bt.cdc.gov/agent/smallpox/overview/disease-facts.asp }}</ref>
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| ==References==
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| {{Reflist|2}}
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| [[Category:Needs content]]
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| [[Category:Disease]]
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| [[Category:Infectious disease]]
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| [[Category:Pediatrics]]
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| [[Category:Smallpox]]
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| [[Category:Viral diseases]]
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| [[Category:Poxviruses]]
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| {{WH}}
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| {{WS}}
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