Alprostadil (suppository): Difference between revisions

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{{drugbox
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| IUPAC_name = 7-[3-hydroxy-2-(3-hydroxyoct-1-enyl)- 5-oxo-cyclopentyl] heptanoic acid
|authorTag=<!--Overview-->
| image =
|aOrAn=a
| CAS_number = 745-65-3
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| ATC_prefix = C01
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| PubChem = 149351
 
| DrugBank = APRD00785
* Content
| C=20 | H=34 | O=5
 
| molecular_weight = 354.481 g/mol
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__NOTOC__
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{{LabelImage
==Overview==
|fileName={{PAGENAME}}11.png
'''Alprostadil''' is the pharmaceutical name for  [[prostaglandin]] E<sub>1</sub>.  It is used as a drug in the treatment of [[erectile dysfunction]] and has [[vasodilatory]] properties.<ref name=dorlands>{{Dorlands|a_26|12123006}}</ref>
}}
{{LabelImage
|fileName={{PAGENAME}}11.png
}}
<!--Pill Image-->


==Sexual Dysfunction==
Aprostidil is sold in the United States under the brand name Muse.<ref>[http://www.drugdigest.org/DD/DVH/Uses/0,3915,550749|Muse,00.html Muse].</ref> It is also sold as Caverject and Edex.


Muse delivers alprostadil as a penile [[suppository]], inserted into the urethra, at least ten minutes before the erection will be needed. Caverject and Edex are similarly fast-acting, but are actually injected directly into the [[corpus cavernosum  penis|corpus cavernosum of the penis]].


This drug is reputed to work for erectile dysfunction for 30 to 60 minutes.
<!--Label Display Image-->


This drug, following on the coattails of [[Viagra]], has failed to achieve comparable above-ground market share in the United States, perhaps in part because of the invasive means of delivery.


NexMed is developing transdermal forumulations&mdash;Alprox-TD(R) for men with erectile dysfunction and Femprox(R) for female sexual arousal disorder.  Alprox-TD(R) has been selling in China and in Hong Kong since October 2001 and April 2002, respectively.
Two Phase III studies have been completed for this product, and the Company is seeking regulatory approval in the U.S., Canada and Europe.
<ref name=nexm>{{cite web
| title=NEXM: Dutton Sees Strong Speculative Buy and 12-Month Price Double
| url=http://www.tradingmarkets.com/.site/news/Stock%20News/722371/
| author=Fain Hughes
| date=2007-10-29
| accessdate=2007-11-01}}</ref>


==Other Uses==
Aprostadil is also used in maintaining a [[patent ductus arteriosus]] in the [[fetus]]. This is primarily useful when there is threat of premature closure of the ductus arteriosus.<ref name=dorlands />


==References==
{{Reflist|2}}


{{Urologicals}}
<!--Category-->
{{Prostaglandins}}


[[Category:Prostaglandins]]
[[Category:Cardiovascular Drugs]]
[[Category:Drug]]
[[Category:Drug]]

Revision as of 19:40, 12 February 2015

Alprostadil (suppository)
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];

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Black Box Warning

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content

Overview

Alprostadil (suppository) is a {{{drugClass}}} that is FDA approved for the {{{indicationType}}} of {{{indication}}}. There is a Black Box Warning for this drug as shown here. Common adverse reactions include .

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Condition1
  • Dosing Information
  • Dosage
Condition2
  • Dosing Information
  • Dosage
Condition3
  • Dosing Information
  • Dosage
Condition4
  • Dosing Information
  • Dosage

Off-Label Use and Dosage (Adult)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Alprostadil (suppository) in adult patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Alprostadil (suppository) in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding FDA-Labeled Use of Alprostadil (suppository) in pediatric patients.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

Condition1
  • Developed by:
  • Class of Recommendation:
  • Strength of Evidence:
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Guideline-Supported Use of Alprostadil (suppository) in pediatric patients.

Non–Guideline-Supported Use

Condition1
  • Dosing Information
  • Dosage
Condition2

There is limited information regarding Off-Label Non–Guideline-Supported Use of Alprostadil (suppository) in pediatric patients.

Contraindications

  • Condition1

Warnings

ConditionName:
See full prescribing information for complete Boxed Warning.
ConditionName:
  • Content
  • Description

Precautions

  • Description

Adverse Reactions

Clinical Trials Experience

There is limited information regarding Clinical Trial Experience of Alprostadil (suppository) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Alprostadil (suppository) in the drug label.

Body as a Whole
Cardiovascular
Digestive
Endocrine
Hematologic and Lymphatic
Metabolic and Nutritional
Musculoskeletal
Neurologic
Respiratory
Skin and Hypersensitivy Reactions
Special Senses
Urogenital
Miscellaneous

Drug Interactions

  • Drug
  • Description

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA):

  • Pregnancy Category


Pregnancy Category (AUS):

  • Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Alprostadil (suppository) in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Alprostadil (suppository) during labor and delivery.

Nursing Mothers

There is no FDA guidance on the use of Alprostadil (suppository) with respect to nursing mothers.

Pediatric Use

There is no FDA guidance on the use of Alprostadil (suppository) with respect to pediatric patients.

Geriatic Use

There is no FDA guidance on the use of Alprostadil (suppository) with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Alprostadil (suppository) with respect to specific gender populations.

Race

There is no FDA guidance on the use of Alprostadil (suppository) with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Alprostadil (suppository) in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Alprostadil (suppository) in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Alprostadil (suppository) in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Alprostadil (suppository) in patients who are immunocompromised.

Administration and Monitoring

Administration

  • Oral
  • Intravenous

Monitoring

There is limited information regarding Monitoring of Alprostadil (suppository) in the drug label.

  • Description

IV Compatibility

There is limited information regarding IV Compatibility of Alprostadil (suppository) in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

  • Description

Management

  • Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Alprostadil (suppository) in the drug label.

Pharmacology

There is limited information regarding Alprostadil (suppository) Pharmacology in the drug label.

Mechanism of Action

Structure

File:Alprostadil (suppository)01.png
This image is provided by the National Library of Medicine.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Alprostadil (suppository) in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Alprostadil (suppository) in the drug label.

Nonclinical Toxicology

There is limited information regarding Nonclinical Toxicology of Alprostadil (suppository) in the drug label.

Clinical Studies

There is limited information regarding Clinical Studies of Alprostadil (suppository) in the drug label.

How Supplied

Storage

There is limited information regarding Alprostadil (suppository) Storage in the drug label.

Images

Drug Images

{{#ask: Page Name::Alprostadil (suppository) |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}

Package and Label Display Panel

{{#ask: Label Page::Alprostadil (suppository) |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}

Patient Counseling Information

There is limited information regarding Patient Counseling Information of Alprostadil (suppository) in the drug label.

Precautions with Alcohol

  • Alcohol-Alprostadil (suppository) interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Look-Alike Drug Names

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

  1. ↑ Empty citation (help)
  2. ↑ "http://www.ismp.org". External link in |title= (help)

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