PETN: Difference between revisions
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==Overview== | ==Overview== | ||
Like [[nitroglycerin]] (glyceryl trinitrate) and other nitrates, PETN is also used medically as a [[vasodilator]] in the treatment of [[heart disease|heart conditions]]. | Like [[nitroglycerin]] (glyceryl trinitrate) and other nitrates, PETN is also used medically as a [[vasodilator]] in the treatment of [[heart disease|heart conditions]]. These drugs work by releasing the signaling gas [[nitric oxide]] in the body. The heart medicine ''Lentonitrat'' is nearly pure PETN.<ref>{{cite journal|title = The therapeutic role of coronary vasodilators: glyceryl trinitrate, isosorbide dinitrate, and pentaerythritol tetranitrate.|author = Russek H. I.| journal =American Journal of Medical Science| volume = 252| issue = 1| pages = 9–20|year = 1966| pmid = 4957459|doi = 10.1097/00000441-196607000-00002}}</ref> | ||
Monitoring of oral usage of the drug by patients has been performed by determination of plasma levels of several of its hydrolysis products, pentaerythritol dinitrate, pentaerythritol mononitrate and pentaerythritol, in plasma using [[gas chromatography-mass spectrometry]].<ref>R. Baselt, ''Disposition of Toxic Drugs and Chemicals in Man'', 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1201–1203.</ref> | Monitoring of oral usage of the drug by patients has been performed by determination of plasma levels of several of its hydrolysis products, pentaerythritol dinitrate, pentaerythritol mononitrate and pentaerythritol, in plasma using [[gas chromatography-mass spectrometry]].<ref>R. Baselt, ''Disposition of Toxic Drugs and Chemicals in Man'', 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1201–1203.</ref> | ||
==References== | ==References== | ||
Revision as of 19:59, 24 July 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Like nitroglycerin (glyceryl trinitrate) and other nitrates, PETN is also used medically as a vasodilator in the treatment of heart conditions. These drugs work by releasing the signaling gas nitric oxide in the body. The heart medicine Lentonitrat is nearly pure PETN.[1]
Monitoring of oral usage of the drug by patients has been performed by determination of plasma levels of several of its hydrolysis products, pentaerythritol dinitrate, pentaerythritol mononitrate and pentaerythritol, in plasma using gas chromatography-mass spectrometry.[2]
References
- ↑ Russek H. I. (1966). "The therapeutic role of coronary vasodilators: glyceryl trinitrate, isosorbide dinitrate, and pentaerythritol tetranitrate". American Journal of Medical Science. 252 (1): 9–20. doi:10.1097/00000441-196607000-00002. PMID 4957459.
- ↑ R. Baselt, Disposition of Toxic Drugs and Chemicals in Man, 8th edition, Biomedical Publications, Foster City, CA, 2008, pp. 1201–1203.
Template:Antianginals (nitrates)
cs:Pentrit de:Nitropenta eo:PETN it:Tetranitrato di pentaeritrite he:PETN lv:Tetranitropentaeritrīts lt:PETN hu:Pentaeritrit-tetranitrát sk:Pentrit sl:Pentrit fi:PETN sv:Pentyl (sprängämne)