Oxyfedrine: Difference between revisions
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==Overview== | ==Overview== | ||
'''Oxyfedrine''' is a [[vasodilator]]. | '''Oxyfedrine''' is a [[vasodilator]]. | ||
Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating [[angina pectoris]]. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon. | |||
Synergestic effects with [[antibiotic]]s have been suggested.<ref name="pmid15802815">{{cite journal |author=Mazumdar K, Dutta NK, Kumar KA, Dastidar SG |title=In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains |journal=Biol. Pharm. Bull. |volume=28 |issue=4 |pages=713–7 |date=April 2005 |pmid=15802815 |doi= 10.1248/bpb.28.713|url=http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/28.713?from=PubMed |format={{dead link|date=May 2009}} |last3=Kumar}}</ref> | |||
{{Vasodilators used in cardiac diseases}} | {{Vasodilators used in cardiac diseases}} |
Revision as of 21:17, 24 July 2014
Clinical data | |
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PubChem CID | |
E number | {{#property:P628}} |
ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
Chemical and physical data | |
Formula | C19H23NO3 |
Molar mass | 313.39 g/mol |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Oxyfedrine is a vasodilator. Oxyfedrine was found to depress the tonicity of coronary vessels, improve myocardial metabolism (so that heart can sustain hypoxia better) and also exert a positive chronotropic and inotrophic effects, thereby not precipitating angina pectoris. The latter property (positive chronotropic and inotrophic effects) is particularly important, because other vasodilators used in angina may be counter productive causing coronary steal phenomenon.
Synergestic effects with antibiotics have been suggested.[1]
- ↑ Mazumdar K, Dutta NK, Kumar KA, Dastidar SG; Kumar (April 2005). "In vitro and in vivo synergism between tetracycline and the cardiovascular agent oxyfedrine HCl against common bacterial strains" ([dead link]). Biol. Pharm. Bull. 28 (4): 713–7. doi:10.1248/bpb.28.713. PMID 15802815. Missing
|last2=
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