Yersinia pestis infection natural history, complications and prognosis: Difference between revisions
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If [[plague]] patients are not given specific [[antibiotic]] therapy, the disease can progress rapidly to death. About 14% (1 in 7) of all plague cases in the United States are fatal. | If [[plague]] patients are not given specific [[antibiotic]] therapy, the disease can progress rapidly to death. About 14% (1 in 7) of all plague cases in the United States are fatal. | ||
== | ==Prognosis== | ||
Untreated bubonic plague has a case fatality of rate 50-60%, with proper identification and prompt treatment the case fatality decreases to around 7%. Untreated septicemia or pneumonic plague is almost universally fatal if untreated early on. Even with proper therapy the latter may lead to mortality rates as high as 50%. | Despite being a treatable disease, plague is still associated with a high case fatality rate, often attributable to late recognition and inappropriate antibiotic therapy. Untreated bubonic plague has a case fatality of rate 50-60%, with proper identification and prompt treatment the case fatality decreases to around 7%.<ref name="pmid20151494">{{cite journal| author=| title=Human plague: review of regional morbidity and mortality, 2004-2009. | journal=Wkly Epidemiol Rec | year= 2009 | volume= 85 | issue= 6 | pages= 40-5 | pmid=20151494 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20151494 }} </ref> Untreated septicemia or pneumonic plague is almost universally fatal if untreated early on. Even with proper therapy the latter may lead to mortality rates as high as 50%. <ref name="mendel">Dennis DT, Mead PS. Yersinia species, including plague. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Elsevier Churchill-Livingstone; 2009:chap 229.</ref> | ||
==References== | ==References== |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Assistant Editors-In-Chief: Esther Lee, M.A.
Overview
If plague patients are not given specific antibiotic therapy, the disease can progress rapidly to death. About 14% (1 in 7) of all plague cases in the United States are fatal.
Prognosis
Despite being a treatable disease, plague is still associated with a high case fatality rate, often attributable to late recognition and inappropriate antibiotic therapy. Untreated bubonic plague has a case fatality of rate 50-60%, with proper identification and prompt treatment the case fatality decreases to around 7%.[1] Untreated septicemia or pneumonic plague is almost universally fatal if untreated early on. Even with proper therapy the latter may lead to mortality rates as high as 50%. [2]
References
- ↑ "Human plague: review of regional morbidity and mortality, 2004-2009". Wkly Epidemiol Rec. 85 (6): 40–5. 2009. PMID 20151494.
- ↑ Dennis DT, Mead PS. Yersinia species, including plague. In: Mandell GL, Bennett JE, Dolin R, eds. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 7th ed. Philadelphia, Pa.: Elsevier Churchill-Livingstone; 2009:chap 229.