Colestilan: Difference between revisions
No edit summary |
No edit summary |
||
| Line 33: | Line 33: | ||
==Overview== | ==Overview== | ||
'''Colestilan''' ([[International Nonproprietary Name|INN]], trade name '''BindRen''') is a [[medication]] that acts as a [[phosphate binder]]<ref name="Klement">{{cite journal| author = A. Klement| date = 11 November 2013| title = Dialysepflichtig – weniger Phosphat mit BindRen| journal = Österreichische Apothekerzeitung| issue = 23/2013| page = 28f| language = German}}</ref> and [[bile acid sequestrant]]. | '''Colestilan''' ([[International Nonproprietary Name|INN]], trade name '''BindRen''') is a [[medication]] that acts as a [[phosphate binder]]<ref name="Klement">{{cite journal| author = A. Klement| date = 11 November 2013| title = Dialysepflichtig – weniger Phosphat mit BindRen| journal = Österreichische Apothekerzeitung| issue = 23/2013| page = 28f| language = German}}</ref> and [[bile acid sequestrant]]. | ||
==Clinical Use== | ==Clinical Use== | ||
| Line 49: | Line 49: | ||
==Chemistry and Mechanism of Action== | ==Chemistry and Mechanism of Action== | ||
Colestilan is a cross-linked [[copolymer]] of 2-methylimidazole and [[epichlorohydrin]] and works as an anion exchanger resin with affinity to [[phosphate]], [[bile acid]] anions and [[urate]]. It binds these anions in the gut and removes them from the [[enterohepatic circulation]]. Colestilan is not absorbed from the gut, but is excreted together with the bound anions. | Colestilan is a cross-linked [[copolymer]] of 2-methylimidazole and [[epichlorohydrin]] and works as an anion exchanger resin with affinity to [[phosphate]], [[bile acid]] anions and [[urate]]. It binds these anions in the gut and removes them from the [[enterohepatic circulation]]. Colestilan is not absorbed from the gut, but is excreted together with the bound anions. | ||
==References== | ==References== | ||
Latest revision as of 17:00, 27 July 2014
 | |
| Clinical data | |
|---|---|
| Routes of administration | Oral |
| Legal status | |
| Legal status |
|
| Identifiers | |
| |
| CAS Number | |
| PubChem CID | |
| E number | {{#property:P628}} |
| ECHA InfoCard | {{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value). |
| Chemical and physical data | |
| Formula | C7H11ClN2O |
| Molar mass | 174.62 g/mol |
| 3D model (JSmol) | |
| |
|
WikiDoc Resources for Colestilan |
|
Articles |
|---|
|
Most recent articles on Colestilan |
|
Media |
|
Evidence Based Medicine |
|
Clinical Trials |
|
Ongoing Trials on Colestilan at Clinical Trials.gov Clinical Trials on Colestilan at Google
|
|
Guidelines / Policies / Govt |
|
US National Guidelines Clearinghouse on Colestilan
|
|
Books |
|
News |
|
Commentary |
|
Definitions |
|
Patient Resources / Community |
|
Patient resources on Colestilan Discussion groups on Colestilan Patient Handouts on Colestilan Directions to Hospitals Treating Colestilan Risk calculators and risk factors for Colestilan
|
|
Healthcare Provider Resources |
|
Causes & Risk Factors for Colestilan |
|
Continuing Medical Education (CME) |
|
International |
|
|
|
Business |
|
Experimental / Informatics |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Colestilan (INN, trade name BindRen) is a medication that acts as a phosphate binder[1] and bile acid sequestrant.
Clinical Use
Colestilan is used for the treatment of hyperphosphataemia (too high phosphate concentrations in the blood serum) in patients undergoing dialysis, including peritoneal dialysis.[1][2]
Contraindications
Colestilan is contraindicated in patients with bowel obstruction.[2]
Interactions
The substance can inhibit the resorption of other drugs, as well as fat soluble vitamins (A, D, E, K) and folate, from the gut.[1] Resulting lower blood levels can be clinically problematic with immunosuppressant and antiepileptic drugs.[2]
Adverse Effects
Adverse effects include gastrointestinal problems such as constipation, as well as vitamin and calcium deficiency. Vitamin K deficiency sometimes causes gastrointestinal bleeding.[1][2]
Chemistry and Mechanism of Action
Colestilan is a cross-linked copolymer of 2-methylimidazole and epichlorohydrin and works as an anion exchanger resin with affinity to phosphate, bile acid anions and urate. It binds these anions in the gut and removes them from the enterohepatic circulation. Colestilan is not absorbed from the gut, but is excreted together with the bound anions.
References
- Pages with script errors
- CS1 maint: Unrecognized language
- Drugs with non-standard legal status
- E number from Wikidata
- ECHA InfoCard ID from Wikidata
- Articles without EBI source
- Chemical pages without ChemSpiderID
- Chemical pages without DrugBank identifier
- Articles without KEGG source
- Articles without InChI source
- Articles without UNII source
- Drugs missing an ATC code
- Articles containing unverified chemical infoboxes
- Drug
- Cardiovascular Drugs
- Bile acid sequestrants