Hepatitis C natural history: Difference between revisions
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==Natural History== | ==Natural History== | ||
Upon exposure, HCV causes an acute phase that is | Upon exposure, HCV causes an acute phase that is asymptomatic in approximately 80% of cases. Acute HVC is characterized by its persistence to a duration of less than 6 months. In 15-45% of cases, HCV is an isolated acute infection almost with no chronic sequelae, even if no treatment was administered whatsoever. Patients exposed to HCV will subsequently develop anti-HCV antibodies but undetectable viral levels and negative HCV RNA. | ||
In the majority of cases, however, HCV persists beyond 6 months and individuals thus become chronic carriers of HCV. Chronic HCV occurs in approximately 55-85% of patients. These patients will have positive anti-HCV antibodies and positive nucleic acid test (NAT) for HCV RNA, demonstrating the persistence of HCV and inability to appropriately clear the infection.<ref name="pmid21139063">{{cite journal| author=Thomson EC, Fleming VM, Main J, Klenerman P, Weber J, Eliahoo J et al.| title=Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. | journal=Gut | year= 2011 | volume= 60 | issue= 6 | pages= 837-45 | pmid=21139063 | doi=10.1136/gut.2010.217166 | pmc=PMC3095479 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21139063 }} </ref><ref name="pmid12851873">{{cite journal| author=Gerlach JT, Diepolder HM, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A et al.| title=Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance. | journal=Gastroenterology | year= 2003 | volume= 125 | issue= 1 | pages= 80-8 | pmid=12851873 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12851873 }} </ref> | In the majority of cases, however, HCV persists beyond 6 months and individuals thus become chronic carriers of HCV. Chronic HCV occurs in approximately 55-85% of patients. These patients will have positive anti-HCV antibodies and positive nucleic acid test (NAT) for HCV RNA, demonstrating the persistence of HCV and inability to appropriately clear the infection.<ref name="pmid21139063">{{cite journal| author=Thomson EC, Fleming VM, Main J, Klenerman P, Weber J, Eliahoo J et al.| title=Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men. | journal=Gut | year= 2011 | volume= 60 | issue= 6 | pages= 837-45 | pmid=21139063 | doi=10.1136/gut.2010.217166 | pmc=PMC3095479 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21139063 }} </ref><ref name="pmid12851873">{{cite journal| author=Gerlach JT, Diepolder HM, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A et al.| title=Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance. | journal=Gastroenterology | year= 2003 | volume= 125 | issue= 1 | pages= 80-8 | pmid=12851873 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12851873 }} </ref> | ||
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[[Image:HCV_NH.png|thumb|600px|center|Natural History of HCV [http://www.who.int/hiv/pub/hepatitis/hepatitis-c-guidelines/en/ Source]]] | [[Image:HCV_NH.png|thumb|600px|center|Natural History of HCV [http://www.who.int/hiv/pub/hepatitis/hepatitis-c-guidelines/en/ Source]]] | ||
<br> | <br> | ||
==Prognosis== | |||
===Acute HCV Infection<ref name="pmid16614742">{{cite journal| author=Chen SL, Morgan TR| title=The natural history of hepatitis C virus (HCV) infection. | journal=Int J Med Sci | year= 2006 | volume= 3 | issue= 2 | pages= 47-52 | pmid=16614742 | doi= | pmc=PMC1415841 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16614742 }} </ref>=== | |||
*Clearance of HCV RNA: 15-45% | |||
*Progression to chronic infection: 55-85% | |||
*Fulminant Hepatitis: Rare | |||
===Chronic HCV Infection<ref name="pmid16614742">{{cite journal| author=Chen SL, Morgan TR| title=The natural history of hepatitis C virus (HCV) infection. | journal=Int J Med Sci | year= 2006 | volume= 3 | issue= 2 | pages= 47-52 | pmid=16614742 | doi= | pmc=PMC1415841 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16614742 }} </ref>=== | |||
*Cirrhosis after 20 years: 10-20% | |||
*Decompensated cirrhosis: 50% survival rate at 5 years | |||
*Hepatocellular carcinoma: 1-4% per year | |||
==Complications== | ==Complications== |
Revision as of 06:01, 28 July 2014
Hepatitis C |
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Hepatitis C natural history On the Web |
American Roentgen Ray Society Images of Hepatitis C natural history |
Risk calculators and risk factors for Hepatitis C natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Natural History
Upon exposure, HCV causes an acute phase that is asymptomatic in approximately 80% of cases. Acute HVC is characterized by its persistence to a duration of less than 6 months. In 15-45% of cases, HCV is an isolated acute infection almost with no chronic sequelae, even if no treatment was administered whatsoever. Patients exposed to HCV will subsequently develop anti-HCV antibodies but undetectable viral levels and negative HCV RNA.
In the majority of cases, however, HCV persists beyond 6 months and individuals thus become chronic carriers of HCV. Chronic HCV occurs in approximately 55-85% of patients. These patients will have positive anti-HCV antibodies and positive nucleic acid test (NAT) for HCV RNA, demonstrating the persistence of HCV and inability to appropriately clear the infection.[1][2]
![](/images/2/28/HCV_NH.png)
Prognosis
Acute HCV Infection[3]
- Clearance of HCV RNA: 15-45%
- Progression to chronic infection: 55-85%
- Fulminant Hepatitis: Rare
Chronic HCV Infection[3]
- Cirrhosis after 20 years: 10-20%
- Decompensated cirrhosis: 50% survival rate at 5 years
- Hepatocellular carcinoma: 1-4% per year
Complications
One major complications of chronic HCV infection are cirrhosis, which ultimately lead to a decompensated state, or transform into a malignant hepatocellular carcinoma (HCC).[4] Not all patients develop cirrhosis at the same rate; exposure to other risk factors of cirrhosis, such as alcohol, HBV or HIV infection, or immunocompromised states may hasten fibrosis of the liver and development of HCC.[5]
Chronic HCV eventually progresses to cause hepatic cirrhosis due to persistence of tissue inflammation and necrosis, along with fibrogenesis and deposition of components in the extracellular matrix. When left untreated, 15-30% of patients with chronic HCV develop cirrhosis within 20 years.[4]
Similarly, HCC is a known complication of chronic HCV infection. Patients with HCV develop HCC when the liver reaches its cirrhotic stage. The annual risk of HCC in patients with cirrhosis is about 2-4%.
Extrahepatic complications of HCV infection[6][4]:
- Cryoglobulinemia
- Glomerulonephritis
- Thyroiditis
- Sjogren syndrome
- Insulin resistance and type-2 diabetes mellitus
- Porphyria cutanea tarda
- Lichen Planus
- Hodgkin's and non-Hodgkin's lymphoma
- Seronegative arthritis
- Cognitive dysfunction
- Depression
Prognosis
- Acute Infection
- 20% recover
- 80% have persistent infection
- 30% of these patients develop cirrhosis
- Genotype
- Predicts response to treatment
- Genotype 1 less responsive than types 2 & 3
References
- ↑ Thomson EC, Fleming VM, Main J, Klenerman P, Weber J, Eliahoo J; et al. (2011). "Predicting spontaneous clearance of acute hepatitis C virus in a large cohort of HIV-1-infected men". Gut. 60 (6): 837–45. doi:10.1136/gut.2010.217166. PMC 3095479. PMID 21139063.
- ↑ Gerlach JT, Diepolder HM, Zachoval R, Gruener NH, Jung MC, Ulsenheimer A; et al. (2003). "Acute hepatitis C: high rate of both spontaneous and treatment-induced viral clearance". Gastroenterology. 125 (1): 80–8. PMID 12851873.
- ↑ 3.0 3.1 Chen SL, Morgan TR (2006). "The natural history of hepatitis C virus (HCV) infection". Int J Med Sci. 3 (2): 47–52. PMC 1415841. PMID 16614742.
- ↑ 4.0 4.1 4.2 "Guidelines for the screening, care, and treatment of persons with HCV infection" (PDF). WHO. WHO. April 2014. Retrieved Jul 27 2014. Check date values in:
|accessdate=
(help) - ↑ Freeman AJ, Law MG, Kaldor JM, Dore GJ (2003). "Predicting progression to cirrhosis in chronic hepatitis C virus infection". J Viral Hepat. 10 (4): 285–93. PMID 12823595.
- ↑ Fletcher NF, McKeating JA (2012). "Hepatitis C virus and the brain". J Viral Hepat. 19 (5): 301–6. doi:10.1111/j.1365-2893.2012.01591.x. PMID 22497808.