Hepatitis A causes: Difference between revisions
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==Taxonomy== | ==Taxonomy== | ||
[[Viruses]]; ssRNA] [[viruses]]; ssRNA positive-strand viruses; Picornavirales; [[Picornaviridae]]; [[Hepatovirus]] | [[Viruses]]; ssRNA] [[viruses]]; [[Positive-sense ssRNA virus|ssRNA virus]]; positive-strand viruses; Picornavirales; [[Picornaviridae]]; [[Hepatovirus]] | ||
==Biology== | ==Biology== | ||
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[[Hepatitis A virus]] ([[HAV]]) is a [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. It is 27 nm in length | |||
===Genome=== | |||
The [[HAV]] [[genome]] is coded in 7474 [[nucleotides]], which are divided into three regions: | |||
* 5' untranslated region (742 nucleotides) | |||
* A single long open reading frame that encodes a 2227 amino acid polypeptide (6681 nucleotides) | |||
* 3' noncoding region (63 nucleotides) | |||
The polypeptide encoded by the open reading frame is cotranslationally processed by a viral protease, resulting in four structural and seven nonstructural proteins (figure 1). | |||
Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype. | |||
==Tropism== | ==Tropism== | ||
Revision as of 19:06, 28 July 2014
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Hepatitis A |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatitis A causes On the Web |
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American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
 |
Hepatitis A virus (HAV) is a non-enveloped, icosahedral, ssRNA virus with a single serovar. It is 27 nm in length
Genome
The HAV genome is coded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region (742 nucleotides)
- A single long open reading frame that encodes a 2227 amino acid polypeptide (6681 nucleotides)
- 3' noncoding region (63 nucleotides)
The polypeptide encoded by the open reading frame is cotranslationally processed by a viral protease, resulting in four structural and seven nonstructural proteins (figure 1).
Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype.
Tropism
Natural Reservoir
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
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