Hepatitis A causes: Difference between revisions
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[[Hepatitis A virus]] ([[HAV]]) is a [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. It is | [[Hepatitis A virus]] ([[HAV]]) is a 27 nm, [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. It is in length | ||
===Genome=== | ===Genome=== | ||
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* 3' noncoding region, with 63 [[nucleotides]] | * 3' noncoding region, with 63 [[nucleotides]] | ||
The | The reading frame encodes a [[polypeptide]] that is processed by a [[viral]] [[protease]]. This process takes place cotranslationally, and leads to the formation of: | ||
* Four structural proteins | |||
* Seven nonstructural proteins | |||
Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype. | Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype. | ||
Revision as of 19:11, 28 July 2014
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Hepatitis A |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatitis A causes On the Web |
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American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
 |
Hepatitis A virus (HAV) is a 27 nm, non-enveloped, icosahedral, ssRNA virus with a single serovar. It is in length
Genome
The HAV genome is encoded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region, with 742 nucleotides
- Single reading frame encoding a 2227 amino acid polypeptide, with 6681 nucleotides
- 3' noncoding region, with 63 nucleotides
The reading frame encodes a polypeptide that is processed by a viral protease. This process takes place cotranslationally, and leads to the formation of:
- Four structural proteins
- Seven nonstructural proteins
Four distinct genotypes of HAV have been identified in humans, although they do not appear to have important biological differences [3]. All four genotypes belong to a single serotype.
Tropism
Natural Reservoir
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
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