Hepatitis A causes: Difference between revisions
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[[Hepatitis A virus]] ([[HAV]]) is a 27 nm, [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. So far, 4 different | [[Hepatitis A virus]] ([[HAV]]) is a 27 nm, [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]]. So far, 4 different [[genotype]]s have been identified in [[hepatitis A virus]]es, all belonging to the same [[serotype]].<ref name="pmid1335657">{{cite journal| author=Lemon SM, Jansen RW, Brown EA| title=Genetic, antigenic and biological differences between strains of hepatitis A virus. | journal=Vaccine | year= 1992 | volume= 10 Suppl 1 | issue= | pages= S40-4 | pmid=1335657 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1335657 }} </ref> | ||
===Genome=== | ===Genome=== | ||
Revision as of 19:16, 28 July 2014
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Hepatitis A |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatitis A causes On the Web |
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American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
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Hepatitis A virus (HAV) is a 27 nm, non-enveloped, icosahedral, ssRNA virus with a single serovar. So far, 4 different genotypes have been identified in hepatitis A viruses, all belonging to the same serotype.[2]
Genome
The HAV genome is encoded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region, with 742 nucleotides
- Single reading frame encoding a 2227 amino acid polypeptide, with 6681 nucleotides
- 3' noncoding region, with 63 nucleotides
The reading frame encodes a polypeptide that is processed by a viral protease. This process takes place cotranslationally, and leads to the formation of:
- Four structural proteins
- Seven nonstructural proteins
Tropism
Natural Reservoir
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
|title=(help) - ↑ Lemon SM, Jansen RW, Brown EA (1992). "Genetic, antigenic and biological differences between strains of hepatitis A virus". Vaccine. 10 Suppl 1: S40–4. PMID 1335657.