Hepatitis A causes: Difference between revisions
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==Tropism== | ==Tropism== | ||
Similarly to other [[hepatitis]] viruses, the [[hepatitis A virus]] shows [[tropism]] for the [[liver cells]]. The [[hepatocytes]] represent the predominant site for [[viral replication]]. | Similarly to other [[hepatitis]] viruses, the [[hepatitis A virus]] shows [[tropism]] for the [[liver cells]]. The [[hepatocytes]] represent the predominant site for [[viral replication]].<ref name="pmid9265900">{{cite journal| author=Lemon SM| title=Type A viral hepatitis: epidemiology, diagnosis, and prevention. | journal=Clin Chem | year= 1997 | volume= 43 | issue= 8 Pt 2 | pages= 1494-9 | pmid=9265900 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9265900 }} </ref> | ||
==Natural Reservoir== | ==Natural Reservoir== | ||
Revision as of 19:23, 28 July 2014
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Hepatitis A |
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Diagnosis |
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Treatment |
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Case Studies |
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Hepatitis A causes On the Web |
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American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
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Hepatitis A virus (HAV) is a 27 nm, non-enveloped, icosahedral, ssRNA virus with a single serovar. So far, 4 different genotypes have been identified in hepatitis A viruses, all belonging to the same serotype.[2]
Genome
The HAV genome is encoded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region, with 742 nucleotides
- Single reading frame encoding a 2227 amino acid polypeptide, with 6681 nucleotides
- 3' noncoding region, with 63 nucleotides
The reading frame encodes a polypeptide that is processed by a viral protease. This process takes place cotranslationally, and leads to the formation of:
- Four structural proteins
- Seven nonstructural proteins
Tropism
Similarly to other hepatitis viruses, the hepatitis A virus shows tropism for the liver cells. The hepatocytes represent the predominant site for viral replication.[3]
Natural Reservoir
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
|title=(help) - ↑ Lemon SM, Jansen RW, Brown EA (1992). "Genetic, antigenic and biological differences between strains of hepatitis A virus". Vaccine. 10 Suppl 1: S40–4. PMID 1335657.
- ↑ Lemon SM (1997). "Type A viral hepatitis: epidemiology, diagnosis, and prevention". Clin Chem. 43 (8 Pt 2): 1494–9. PMID 9265900.