Hepatitis A causes: Difference between revisions
Joao Silva (talk | contribs) No edit summary |
Joao Silva (talk | contribs) No edit summary |
||
| Line 4: | Line 4: | ||
==Overview== | ==Overview== | ||
The hepatitis A virus is a [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]] [[hepatovirus]]. Its [[genome]] is encoded in 7474 [[nucleotides]] and the [[virus]] has [[tropism]] for the [[hepatocytes]], where it replicates. Humans are the only [[natural reservoir]] of the [[virus]]. | The [[hepatitis A virus]] is a [[Viral envelope|non-enveloped]], icosahedral, [[Positive-sense ssRNA virus|ssRNA virus]] with a single [[serovar]] [[hepatovirus]]. Its [[genome]] is encoded in 7474 [[nucleotides]] and the [[virus]] has [[tropism]] for the [[hepatocytes]], where it [viral replication|replicates]]. Humans are the only [[natural reservoir]] of the [[virus]]. | ||
==Taxonomy== | ==Taxonomy== | ||
| Line 17: | Line 17: | ||
===Genome=== | ===Genome=== | ||
The [[HAV]] [[genome]] is encoded in 7474 [[nucleotides]], which are divided into three regions: | The [[HAV]] [[genome]] is encoded in 7474 [[nucleotides]], which are divided into three regions: | ||
* 5' untranslated region, with 742 [[nucleotides]] | * 5' untranslated region, with 742 [[nucleotides]] | ||
* Single reading frame encoding a 2227 [[amino acid]] [[polypeptide]], with 6681 [[nucleotides]] | * Single [[reading frame]] encoding a 2227 [[amino acid]] [[polypeptide]], with 6681 [[nucleotides]] | ||
* 3' noncoding region, with 63 [[nucleotides]] | * 3' noncoding region, with 63 [[nucleotides]] | ||
The [[reading frame]] encodes a [[polypeptide]] that is processed by a [[viral]] [[protease]]. This process takes place cotranslationally, and leads to the formation of: | The [[reading frame]] encodes a [[polypeptide]] that is processed by a [[viral]] [[protease]]. This process takes place cotranslationally, and leads to the formation of: | ||
* Four structural proteins | * Four structural [[proteins]] | ||
* Seven nonstructural proteins | * Seven nonstructural [[proteins]] | ||
==Tropism== | ==Tropism== | ||
| Line 38: | Line 37: | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Foodborne illnesses]] | [[Category:Foodborne illnesses]] | ||
[[Category:hepatitis|A]] | [[Category:hepatitis|A]] | ||
Revision as of 19:35, 28 July 2014
|
Hepatitis A |
|
Diagnosis |
|
Treatment |
|
Case Studies |
|
Hepatitis A causes On the Web |
|
American Roentgen Ray Society Images of Hepatitis A causes |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2]
Overview
The hepatitis A virus is a non-enveloped, icosahedral, ssRNA virus with a single serovar hepatovirus. Its genome is encoded in 7474 nucleotides and the virus has tropism for the hepatocytes, where it [viral replication|replicates]]. Humans are the only natural reservoir of the virus.
Taxonomy
Viruses; ssRNA] viruses; ssRNA virus; positive-strand viruses; Picornavirales; Picornaviridae; Hepatovirus
Biology
 |
Hepatitis A virus (HAV) is a 27 nm, non-enveloped, icosahedral, ssRNA virus with a single serovar. So far, 4 different genotypes have been identified in hepatitis A viruses, all belonging to the same serotype.[2]
Genome
The HAV genome is encoded in 7474 nucleotides, which are divided into three regions:
- 5' untranslated region, with 742 nucleotides
- Single reading frame encoding a 2227 amino acid polypeptide, with 6681 nucleotides
- 3' noncoding region, with 63 nucleotides
The reading frame encodes a polypeptide that is processed by a viral protease. This process takes place cotranslationally, and leads to the formation of:
Tropism
Similarly to other hepatitis viruses, the hepatitis A virus shows tropism for the liver cells. The hepatocytes represent the predominant site for viral replication.[3]
Natural Reservoir
- Humans are the only natural reservoir of the virus.[4]
- There are no insect or animal vectors.[4]
- A chronic HAV carrier state has not been reported.[4]
References
- ↑ "http://phil.cdc.gov/phil/details.asp". External link in
|title=(help) - ↑ Lemon SM, Jansen RW, Brown EA (1992). "Genetic, antigenic and biological differences between strains of hepatitis A virus". Vaccine. 10 Suppl 1: S40–4. PMID 1335657.
- ↑ Lemon SM (1997). "Type A viral hepatitis: epidemiology, diagnosis, and prevention". Clin Chem. 43 (8 Pt 2): 1494–9. PMID 9265900.
- ↑ 4.0 4.1 4.2 "Hepatitis A".