Hepatitis C classification: Difference between revisions

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Only recently, a 7th genotype was confirmed. In less than 10 years, the number of assigned subtypes increased from only 18 in 2005 to 67. Similarly, the number of complete coding sequences increased from just 238 to at least 1,300.<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref> The number of incomplete sequences is currently greater than 500, some of which are expected be completed in the near future.
Only recently, a 7th genotype was confirmed. In less than 10 years, the number of assigned subtypes increased from only 18 in 2005 to 67. Similarly, the number of complete coding sequences increased from just 238 to at least 1,300.<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref> The number of incomplete sequences is currently greater than 500, some of which are expected be completed in the near future.


The following table shows the different HCV genotypes and their corresponding loci/isolates:
The following table shows the different HCV genotypes and their corresponding loci/isolates<ref name="pmid24115039">{{cite journal| author=Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT et al.| title=Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource. | journal=Hepatology | year= 2014 | volume= 59 | issue= 1 | pages= 318-27 | pmid=24115039 | doi=10.1002/hep.26744 | pmc=PMC4063340 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24115039  }} </ref> :
{| style="border: 0px; font-size: 90%; margin: 3px;" align=center
|+HCV Genotypes and Subtypes'''''
! style="background: #4479BA; width: 120px;" | {{fontcolor|#FFF|Genotype}}
! style="background: #4479BA; width: 550px;" | {{fontcolor|#FFF|Loci/Isolates}}
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 1'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCPLYPRE, HPCCGAA
*b: HPCJCG, HPCHUMR
*c: HPCCGS, AY051292
*e: 148636
*g: 1804
*h: EBW443, EBW9 
*l: 136142, EBW424
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 2'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCPOLP, JFH-1
*b: HPCJ8G, JPUT971017
*c: BEBE1
*d: QC259 
*e: QC64 
*i: D54
*j: C1799
*k: VAT96
*m: QC178, BID-G1314
*q: 963, 852
*r: QC283
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 3'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: HPCEGS, HPCK3A
*b: HPCFG
*g: BID-G1243, QC260
*h: QC29
*i: IND-HCV, BID-G1244
*k: HPCJK049E1, QC105
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 4'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: ED43
*b: QC264
*c: QC381 
*d: 03-18, QC382
*f: IFBT88, PS6
*g: QC193
*k: PS3, QC383
*l: QC274
*m: QC249
*n: QC97
*o: QC93
*p: QC139
*q: QC262 
*r: QC384 
*t: QC155
*v: CYHCV073, BID-G1248
*w: P212, P245
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 5'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: EUH1480, SA13
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 6'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*6a: EUHK2,6a33
*6b: Th580
*6c: Th846
*6d: VN235
*6e: GX004
*6f: C-0044
*6g: HPCJK046E2 
*6h: VN004
*6i: Th602
*6j: Th553
*6k: VN405
*6l: 537796
*6m: B4/92
*6n: KM42, D86/93
*6o: QC227 
*6p: QC216
*6q: QC99
*6r: QC245 
*6s: QC66
*6t: VT21, D49 
*6u: D83
*6v: NK46, KMN-02
*6w: GZ52557, D140
*6xa: DH012, DH028
|-
| style="padding: 5px 5px; background: #DCDCDC;" |'''Genotype 7'''
| style="padding: 5px 5px; background: #F5F5F5;" |
*a: QC69
|-
|}
<sup><center>Adapted from Smith DB, Bukh J, Kuiken C, et al. Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource. ''Hepatology''.2014;59(1):318-327</center></sup>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}

Revision as of 20:30, 29 July 2014

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Overview

Classification

Shortly after the discovery of hepatitis c virus, various isolations revealed that the virus is in fact genetically diverse. According to the genomic sequence heterogeneity, HCV has been classified into 6 major genotypes, designated 1-11, 18 assigned subtypes, designated a, b, c, etc., 58 others pending assignment, and hundreds of strains, numbered 1, 2, 3, etc.[1]

Only recently, a 7th genotype was confirmed. In less than 10 years, the number of assigned subtypes increased from only 18 in 2005 to 67. Similarly, the number of complete coding sequences increased from just 238 to at least 1,300.[1] The number of incomplete sequences is currently greater than 500, some of which are expected be completed in the near future.

The following table shows the different HCV genotypes and their corresponding loci/isolates[1] :

HCV Genotypes and Subtypes
Genotype Loci/Isolates
Genotype 1
  • a: HPCPLYPRE, HPCCGAA
  • b: HPCJCG, HPCHUMR
  • c: HPCCGS, AY051292
  • e: 148636
  • g: 1804
  • h: EBW443, EBW9
  • l: 136142, EBW424
Genotype 2
  • a: HPCPOLP, JFH-1
  • b: HPCJ8G, JPUT971017
  • c: BEBE1
  • d: QC259
  • e: QC64
  • i: D54
  • j: C1799
  • k: VAT96
  • m: QC178, BID-G1314
  • q: 963, 852
  • r: QC283
Genotype 3
  • a: HPCEGS, HPCK3A
  • b: HPCFG
  • g: BID-G1243, QC260
  • h: QC29
  • i: IND-HCV, BID-G1244
  • k: HPCJK049E1, QC105
Genotype 4
  • a: ED43
  • b: QC264
  • c: QC381
  • d: 03-18, QC382
  • f: IFBT88, PS6
  • g: QC193
  • k: PS3, QC383
  • l: QC274
  • m: QC249
  • n: QC97
  • o: QC93
  • p: QC139
  • q: QC262
  • r: QC384
  • t: QC155
  • v: CYHCV073, BID-G1248
  • w: P212, P245
Genotype 5
  • a: EUH1480, SA13
Genotype 6
  • 6a: EUHK2,6a33
  • 6b: Th580
  • 6c: Th846
  • 6d: VN235
  • 6e: GX004
  • 6f: C-0044
  • 6g: HPCJK046E2
  • 6h: VN004
  • 6i: Th602
  • 6j: Th553
  • 6k: VN405
  • 6l: 537796
  • 6m: B4/92
  • 6n: KM42, D86/93
  • 6o: QC227
  • 6p: QC216
  • 6q: QC99
  • 6r: QC245
  • 6s: QC66
  • 6t: VT21, D49
  • 6u: D83
  • 6v: NK46, KMN-02
  • 6w: GZ52557, D140
  • 6xa: DH012, DH028
Genotype 7
  • a: QC69
Adapted from Smith DB, Bukh J, Kuiken C, et al. Expanded Classification of Hepatitis C Virus Into 7 Genotypes and 67 Subtypes: Updated Criteria and Genotype Assignment Web Resource. Hepatology.2014;59(1):318-327

References

  1. ↑ 1.0 1.1 1.2 Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT; et al. (2014). "Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: updated criteria and genotype assignment web resource". Hepatology. 59 (1): 318–27. doi:10.1002/hep.26744. PMC 4063340. PMID 24115039.
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