Hepatitis D other diagnostic studies: Difference between revisions
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===Liver Biopsy:=== | ===Liver Biopsy:=== | ||
Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good. | Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good. | ||
*Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for [[cirrhosis]] or [[fibrosis]]. | *Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for [[cirrhosis]] or [[fibrosis]]. | ||
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===Endoscopy=== | ===Endoscopy=== | ||
*Patients with [[liver cirrhosis]] should be evaluated for the presence of [[esophageal varices]].<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref> | *Patients with [[liver cirrhosis]] should be evaluated for the presence of [[esophageal varices]].<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref><ref name="pmid19840253">{{cite journal| author=Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y et al.| title=Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis. | journal=Liver Int | year= 2010 | volume= 30 | issue= 3 | pages= 430-7 | pmid=19840253 | doi=10.1111/j.1478-3231.2009.02140.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=19840253 }} </ref> | ||
==References== | ==References== | ||
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[[Category:Infectious disease]] | [[Category:Infectious disease]] | ||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 04:20, 8 August 2014
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Hepatitis D |
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Diagnosis |
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Treatment |
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Hepatitis D other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Hepatitis D other diagnostic studies |
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Risk calculators and risk factors for Hepatitis D other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]
Overview
Other Diagnostic Studies
Liver Biopsy:
Liver transplant is the only remaining treatment option for patients with liver failure, who are not candidates for treatment with interferon-alpha. The outcome of liver tranplant in patients with hepatitis D is good.
- Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for cirrhosis or fibrosis.
- Histopathologic findings are similar to that observed in HBV infection. Acidophilic cytoplasm in hepatocytes with lymphocytic infiltrates may be observed.
- Immunohistochemical staining may be positive for HDV antigen with suppression of HBsAg in case of superinfection.
Endoscopy
- Patients with liver cirrhosis should be evaluated for the presence of esophageal varices.[1][2]
References
- ↑ Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.
- ↑ Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y; et al. (2010). "Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis". Liver Int. 30 (3): 430–7. doi:10.1111/j.1478-3231.2009.02140.x. PMID 19840253.