Hepatitis D other diagnostic studies: Difference between revisions
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==Other Diagnostic Studies== | ==Other Diagnostic Studies== | ||
===Liver Biopsy:=== | ===Liver Biopsy:=== | ||
Liver | *[[Liver biopsy]] is not routinely indicated in [[diagnosis]] of acute hepatitis D unless the [[serologic]] diagnosis of [[hepatitis]] is inconclusive. However, [[liver biopsy]] is indicated in chronic liver disease to evaluate for [[cirrhosis]] or [[fibrosis]]. | ||
* | *[[Histopathologic]] findings are similar to that observed in [[HBV infection]]. [[Acidophilic]] cytoplasm in [[hepatocytes]] with [[lymphocytic]] infiltrates may be observed. | ||
*[[Immunohistochemical staining]] may be positive for HDV antigen with suppression of [[HBsAg]] in case of [[superinfection]]. | |||
*[[Immunohistochemical staining]] may be positive for HDV antigen with suppression of [[HBsAg]] in case of superinfection. | |||
===Endoscopy=== | ===Endoscopy=== | ||
Revision as of 17:27, 10 August 2014
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Hepatitis D |
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Diagnosis |
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Treatment |
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Hepatitis D other diagnostic studies On the Web |
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American Roentgen Ray Society Images of Hepatitis D other diagnostic studies |
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Risk calculators and risk factors for Hepatitis D other diagnostic studies |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]
Overview
Other Diagnostic Studies
Liver Biopsy:
- Liver biopsy is not routinely indicated in diagnosis of acute hepatitis D unless the serologic diagnosis of hepatitis is inconclusive. However, liver biopsy is indicated in chronic liver disease to evaluate for cirrhosis or fibrosis.
- Histopathologic findings are similar to that observed in HBV infection. Acidophilic cytoplasm in hepatocytes with lymphocytic infiltrates may be observed.
- Immunohistochemical staining may be positive for HDV antigen with suppression of HBsAg in case of superinfection.
Endoscopy
- Patients with liver cirrhosis should be evaluated for the presence of esophageal varices.[1][2]
References
- ↑ Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.
- ↑ Zachou K, Yurdaydin C, Drebber U, Dalekos GN, Erhardt A, Cakaloglu Y; et al. (2010). "Quantitative HBsAg and HDV-RNA levels in chronic delta hepatitis". Liver Int. 30 (3): 430–7. doi:10.1111/j.1478-3231.2009.02140.x. PMID 19840253.