Hepatitis D surgery: Difference between revisions
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The treatment of hepatitis D usually does not involve surgical procedures. | The treatment of hepatitis D usually does not involve surgical procedures. | ||
===Liver Transplantation=== | ===Liver Transplantation=== | ||
[[Liver transplant]] is indicated in patients with end-stage [[liver disease]], or [[liver failure]] secondary to [[HDV infection]], in whom treatment with [[interferon]] is not indicated.<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref> These patients usually have a good outcome, with inhibition of HBV and HDV reinfection when simultaneously treated with nucleoside and nucleotide analogues, and hepatitis B antibodies.<ref name="pmid7843702">{{cite journal| author=Samuel D, Zignego AL, Reynes M, Feray C, Arulnaden JL, David MF et al.| title=Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis. | journal=Hepatology | year= 1995 | volume= 21 | issue= 2 | pages= 333-9 | pmid=7843702 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7843702 }} </ref> | [[Liver transplant]] is indicated in patients with end-stage [[liver disease]], or [[liver failure]] secondary to [[HDV infection]], in whom treatment with [[interferon]] is not indicated.<ref name="pmid23242761">{{cite journal| author=Heidrich B, Manns MP, Wedemeyer H| title=Treatment options for hepatitis delta virus infection. | journal=Curr Infect Dis Rep | year= 2013 | volume= 15 | issue= 1 | pages= 31-8 | pmid=23242761 | doi=10.1007/s11908-012-0307-z | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23242761 }} </ref> These patients usually have a good outcome, with inhibition of HBV and HDV reinfection when simultaneously treated with nucleoside and nucleotide analogues, and hepatitis B antibodies.<ref name="pmid7843702">{{cite journal| author=Samuel D, Zignego AL, Reynes M, Feray C, Arulnaden JL, David MF et al.| title=Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis. | journal=Hepatology | year= 1995 | volume= 21 | issue= 2 | pages= 333-9 | pmid=7843702 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7843702 }} </ref> However, HDV remains latent and can be detected in the new liver for several months after the transplant. Therefore prevention of HBV reinfection should be maintained, in order to simultaneously avoid resurgence of HDV. | ||
==References== | ==References== | ||
Revision as of 12:14, 8 August 2014
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Hepatitis D |
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Diagnosis |
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Treatment |
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Hepatitis D surgery On the Web |
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American Roentgen Ray Society Images of Hepatitis D surgery |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Varun Kumar, M.B.B.S. [2]; João André Alves Silva, M.D. [3] Jolanta Marszalek, M.D. [4]
Overview
Surgery
The treatment of hepatitis D usually does not involve surgical procedures.
Liver Transplantation
Liver transplant is indicated in patients with end-stage liver disease, or liver failure secondary to HDV infection, in whom treatment with interferon is not indicated.[1] These patients usually have a good outcome, with inhibition of HBV and HDV reinfection when simultaneously treated with nucleoside and nucleotide analogues, and hepatitis B antibodies.[2] However, HDV remains latent and can be detected in the new liver for several months after the transplant. Therefore prevention of HBV reinfection should be maintained, in order to simultaneously avoid resurgence of HDV.
References
- ↑ Heidrich B, Manns MP, Wedemeyer H (2013). "Treatment options for hepatitis delta virus infection". Curr Infect Dis Rep. 15 (1): 31–8. doi:10.1007/s11908-012-0307-z. PMID 23242761.
- ↑ Samuel D, Zignego AL, Reynes M, Feray C, Arulnaden JL, David MF; et al. (1995). "Long-term clinical and virological outcome after liver transplantation for cirrhosis caused by chronic delta hepatitis". Hepatology. 21 (2): 333–9. PMID 7843702.