Salmonellosis future or investigational therapies: Difference between revisions
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==Overview== | ==Overview== | ||
The different [[genotype]]s of [[salmonella]] have been associated with different manifestations of the disease, yet, the process is not fully understood. Future studies are required to explain the potential [[genetic]] basis | The different [[genotype]]s of [[salmonella]] have been associated with different manifestations of the disease, yet, the process is not fully understood. Future studies are required to explain the potential [[genetic]] basis for the development of invasive non-typhoidal salmonella, and why certain non-typhoidal salmonella strains cause more severe disease than others.<ref name="pmid25136336">{{cite journal| author=Gal-Mor O, Boyle EC, Grassl GA| title=Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ. | journal=Front Microbiol | year= 2014 | volume= 5 | issue= | pages= 391 | pmid=25136336 | doi=10.3389/fmicb.2014.00391 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25136336 }} </ref> | ||
Research for the development of humanized mouse models is also required. These models will allow to understand more of the [[pathogenesis]] of [[salmonella]] in human tissues, as well as to test the [[efficacy]] of new treatments and [[vaccines]].<ref name="pmid25136336">{{cite journal| author=Gal-Mor O, Boyle EC, Grassl GA| title=Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ. | journal=Front Microbiol | year= 2014 | volume= 5 | issue= | pages= 391 | pmid=25136336 | doi=10.3389/fmicb.2014.00391 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25136336 }} </ref> | Research for the development of humanized mouse models is also required. These models will allow to understand more of the [[pathogenesis]] of [[salmonella]] in human tissues, as well as to test the [[efficacy]] of new treatments and [[vaccines]].<ref name="pmid25136336">{{cite journal| author=Gal-Mor O, Boyle EC, Grassl GA| title=Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ. | journal=Front Microbiol | year= 2014 | volume= 5 | issue= | pages= 391 | pmid=25136336 | doi=10.3389/fmicb.2014.00391 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25136336 }} </ref> | ||
Revision as of 23:15, 20 August 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: João André Alves Silva, M.D. [2] Jolanta Marszalek, M.D. [3]
Overview
The different genotypes of salmonella have been associated with different manifestations of the disease, yet, the process is not fully understood. Future studies are required to explain the potential genetic basis for the development of invasive non-typhoidal salmonella, and why certain non-typhoidal salmonella strains cause more severe disease than others.[1]
Research for the development of humanized mouse models is also required. These models will allow to understand more of the pathogenesis of salmonella in human tissues, as well as to test the efficacy of new treatments and vaccines.[1]
References
- ↑ 1.0 1.1 Gal-Mor O, Boyle EC, Grassl GA (2014). "Same species, different diseases: how and why typhoidal and non-typhoidal Salmonella enterica serovars differ". Front Microbiol. 5: 391. doi:10.3389/fmicb.2014.00391. PMID 25136336.