Buschke–Ollendorff syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jesus Rosario Hernandez, M.D. [2].

Synonyms and keywords: Dermatofibrosis lenticularis disseminata.

Buschke–Ollendorff syndrome, also known as Dermatofibrosis lenticularis disseminata, is a rare genetic disorder associated with LEMD3. It is believed to be inherited in an autosomal dominant manner.

It is named for Abraham Buschke and Helene Ollendorff Curth who described it in a 45 year old woman. Its frequency is almost 1 case per every 20'000 people and is equally found in both males and females.

Genetics

File:Autosomal dominant - en.svg

Buschke–Ollendorff syndrome has an autosomal dominant pattern of inheritance.

Buschke–Ollendorff syndrome is inherited in an autosomal dominant manner. This means that the defective gene responsible for the disorder is located on an autosome, and one copy of the defective gene is sufficient to cause the disorder when inherited from a parent who also has the disorder.

Physical examination

Gallery

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