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| ==Overview== | | ==Overview== |
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| '''Pyogenic granuloma''' (also known as a "Eruptive hemangioma", "Granulation tissue-type hemangioma", "Granuloma gravidarum", "Lobular capillary hemangioma", "Pregnancy tumor", and "Tumor of pregnancy"<ref name="Andrews">{{cite book |author=James, William D.; Berger, Timothy G.; et al. |title=Andrews' Diseases of the Skin: Clinical Dermatology |publisher=Saunders Elsevier |location= |year=2006 |pages= |isbn=0-7216-2921-0 |oclc= |doi= |accessdate=}}</ref><ref name="Bolognia">{{cite book |author=Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}}</ref>) is a vascular lesion that occurs on both mucosa and skin, and appears as an [[hyperplasia|overgrowth]] of tissue due to [[irritation]], [[physical trauma]] or [[hormones|hormonal]] factors.<ref name="Fitz2">Freedberg, et al. (2003). ''Fitzpatrick's Dermatology in General Medicine''. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.</ref><ref name="joralsci">{{cite journal | author = Jafarzadeh H, Sanatkhani M, Mohtasham N | title = Oral pyogenic granuloma: a review | journal = J Oral Sci | volume = 48 | issue = 4 | pages = 167–75 |date=December 2006 | pmid = 17220613 | doi = 10.2334/josnusd.48.167| url = http://joi.jlc.jst.go.jp/JST.JSTAGE/josnusd/48.167?from=PubMed| accessdate = 2009-01-04 | format = – <sup>[http://scholar.google.co.uk/scholar?hl=en&lr=&q=intitle%3AOral+pyogenic+granuloma%3A+a+review&as_publication=J+Oral+Sci&as_ylo=2006&as_yhi=2006&btnG=Search Scholar search]</sup>}} {{dead link|date=March 2009}}</ref> It is often found to involve the gums, the skin and [[nasal septum]], and has also been found far from the head such as in the thigh.<ref name="Nthumba">{{cite journal |author=Nthumba PM |title=Giant pyogenic granuloma of the thigh: a case report |journal=J Med Case Reports |volume=2 |issue= 1|pages=95 |year=2008 |pmid=18377654 |pmc=2329656 |doi=10.1186/1752-1947-2-95 |url=http://www.jmedicalcasereports.com/content/2//95}}</ref> | | '''Neonatal acne''' (also known as "Acne infantum," "Acne neonatorum",<ref name="pmid11187144">{{cite journal |author=Holm EA, Jemec GB |title=[Acne neonatorum/acne infantum] |language=Danish |journal=Ugeskr. Laeg. |volume=162 |issue=50 |pages=6856–7 |date=December 2000 |pmid=11187144 |doi= |url=}}</ref> and "Neonatal cephalic pustulosis"<ref name="Bolognia">{{cite book |author=Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. |title=Dermatology: 2-Volume Set |publisher=Mosby |location=St. Louis |year=2007 |pages= |isbn=1-4160-2999-0 |oclc= |doi= |accessdate=}}{{pn|date=March 2012}}</ref> (not to be confused with "[[Benign cephalic histiocytosis]]")) is an acneiform eruption that occurs in newborns or infants, and is often seen on the nose and adjacent portions of the cheeks.<ref name="Fitz2">{{cite book |editor1-first=Irwin M. |editor1-last=Freedberg |editor2-first=Arthur Z. |editor2-last=Eisen |editor3-first=Klauss |editor3-last=Wolff |editor4-first=K. Frank |editor4-last=Austen |editor5-first=Lowell A. |editor5-last=Goldsmith |editor6-first=Stephen |editor6-last=Katz |year=2003 |title=Fitzpatrick's Dermatology in General Medicine |edition=6th |publisher=McGraw-Hill |isbn=978-0-07-138076-8 |page=648}}</ref> |
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| ==History and terminology==
| | The main cause of this condition is not known, but it could be due to the increased sensitivity of the infant's [[sebaceous glands]] to maternal hormones during pregnancy which also leads to a variety of skin conditions in the newborn.Typically, it peaks at around 2 months and rarely needs treatment. Sometimes gels or ointments are applied. |
| Pyogenic granuloma was first described in 1897 by two French surgeons, Poncet and Dor, who named this lesion ''botryomycosis hominis''.<ref>Ferry AP, Zimmerman LE. Granuloma pyogenicum of limbus. Arch Ophthalmol 74:229-230, 1965.</ref>
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| The name for pyogenic granuloma is misleading because it is not a true [[granuloma]]. In actuality, it is a [[capillary hemangioma]] of [[lobular]] subtype which is the reason they are often quite prone to bleeding.<ref name="joralsci"/>
| | ==Physical Examination== |
| | ===Skin=== |
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| It is also not truly ''pyogenic'', ("pus producing") as the cause is traumatic and not infectious.
| | Image:Acne_neonatorum_01.jpeg|Acne neonatorum. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5 |
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| ==Signs and symptoms== | | Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = |
| ===Clinical presentation===
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| The appearance of pyogenic granuloma is usually a [[color]] ranging from red/pink to purple, and can be smooth or lobulated. Younger lesions are more likely to be red because of the high number of blood vessels. Older lesions begin to change into a pink color. Size ranges from a few millimeters to centimeters. This is not to say that the pyogenic granuloma can not be bigger but it is more common to see one within these measurements.{{medical citation needed|date=August 2013}} It can be painful, especially if located in an area of the body where it is constantly disturbed. Pyogenic granulomas can grow rapidly and will often bleed profusely with little or no trauma. Some cases may also include the granuloma "leaking" an oil like substance causing the surface to be damp. This is especially if the granuloma is located on the scalp.{{medical citation needed|date=August 2013}}
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| It is most likely to occur in children and younger adults, and there is a definite [[gender]] difference with more [[female]]s affected than [[men]]. In [[pregnancy|pregnant]] women, it is most likely to occur in the [[first trimester]] with an increasing incidence up until the seventh month and is often seen on the anterior nasal septum as a source of frequent nose bleeds. Pyogenic granulomas appear on the gingiva in 75% of cases, more often in the [[maxilla]]ry than [[Human mandible|mandibular]] jaw. Anterior areas are more often affected than posterior areas. It can also be found on the [[lip]]s, [[tongue]], and inner [[cheek]]. Poor [[oral hygiene]] or trauma are usually precipitating factors.
| | http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5}} |
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| One study has suggested a correlation between pyogenic granuloma and [[Bartonella]] [[seropositivity]].<ref name="pmid11907853">{{cite journal |author=Lee J, Lynde C |title=Pyogenic granuloma: pyogenic again? Association between pyogenic granuloma and Bartonella |journal=J Cutan Med Surg |volume=5 |issue=6 |pages=467–70 |year=2001 |pmid=11907853 |doi=10.1007/s10227-001-0022-0}}</ref> However, this association has been questioned by others.<ref name="pmid16310070">{{cite journal |author=Levy I, Rolain JM, Lepidi H, ''et al.'' |title=Is pyogenic granuloma associated with Bartonella infection? |journal=J. Am. Acad. Dermatol. |volume=53 |issue=6 |pages=1065–6 |date=December 2005 |pmid=16310070 |doi=10.1016/j.jaad.2005.08.046 |url=http://linkinghub.elsevier.com/retrieve/pii/S0190-9622(05)02699-X}}</ref> The appearance of a pyogenic granulomas [[microscope|microscopically]] has a highly vascular granulation tissue. [[Inflammation]] is present. The lesion may have a fibrous character if it is older, and the surface may have [[Ulcer (dermatology)|ulcerations]]. Pyogenic granuloma rarely occurs in the conjunctiva, cornea or connective tissue of the eye following minor local trauma. Grossly these mass lesions resemble those occurring at more common sites. The relationship of this lesion to the lobular capillary hemangioma of skin and oropharyngeal mucosa commonly referred to as pyogenic granuloma is uncertain.
| | Image:Acne_neonatorum_02.jpeg|Acne neonatorum. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5 |
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| ===Associated conditions===
| | Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = |
| Due to its overwhelming incidence on the [[gingiva]], the condition is often associated with two other [[disease]]s, though not because they occur together. Instead, the three are associated with each other because they appear frequently on gingiva - [[peripheral giant cell granuloma]] and [[peripheral ossifying fibroma]]. However, detailed analysis can be used to distinguish these conditions.<ref name="pmid18496485">{{cite journal |author=Salum FG, Yurgel LS, Cherubini K, De Figueiredo MA, Medeiros IC, Nicola FS |title=Pyogenic granuloma, peripheral giant cell granuloma and peripheral ossifying fibroma: retrospective analysis of 138 cases |journal=Minerva Stomatol |volume=57 |issue=5 |pages=227–32 |date=May 2008 |pmid=18496485 |doi= |url=}}</ref>
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| The appearance can be very similar to that of a [[hemangioma]] but unlike hemangiomas they can appear after birth.
| | http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5}} |
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| ==Physical examination== | | Image:Acne_neonatorum_03.jpeg|Acne neonatorum. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5 |
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| ===Gallery=== | | Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = |
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| ====Extremities==== | | http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5}} |
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| <gallery>
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| Image: Granuloma_multiforme_01.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170> | | Image:Acne_neonatorum_04.png|Acne neonatorum. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5 |
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| Image: Granuloma_multiforme_02.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
| | Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = |
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| Image: Granuloma_multiforme_03.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
| | http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5}} |
| | Image:Acne_neonatorum_05.jpeg|Acne neonatorum. <BR><SMALL><SMALL>Adapted from ''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5 |
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| Image: Granuloma_multiforme_04.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
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| Image: Granuloma_multiforme_06.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
| | Dermatology Atlas]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = |
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| </gallery>
| | http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=5}} |
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| ====Neck====
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| <gallery> | | </gallery> |
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| Image: Granuloma_multiforme_05.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
| | == References == |
| | | {{Reflist|2}} |
| Image: Granuloma_multiforme_07.jpeg|Granuloma multiforme. <SMALL><SMALL>''[http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=12 With permission from Dermatology Atlas.]''<ref name="www.atlasdermatologico.com.br">{{Cite web | title = Dermatology Atlas | url = http://www.atlasdermatologico.com.br/disease.jsf?diseaseId=170>
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| ==Treatment==
| | [[Category:Acneiform eruptions]] |
| There is usually no treatment if the pyogenic granuloma occurs during pregnancy since the lesion may heal spontaneously. Recurrent bleeding in either the oral or nasal lesions may necessitate excision and cauterization sooner, however. If aesthetics are a concern, then treatment may be pursued as well. Usually, only minor [[surgery]] may be needed, along with a dental cleaning for oral lesions to remove any [[calculus (dental)|calculus]] or other source of irritation. For nasal lesions, one should be discouraged from any nose-picking.
| | [[Category:Neonatology]] |
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| == References ==
| | {{Cutaneous-condition-stub}} |
| {{Reflist|2}} | |
