Enterovirus 68 pathophysiology: Difference between revisions

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==Pathogenesis==
==Pathogenesis==
Enterovirus 68 belongs to the Human Enterovirus D species (HEV-D), along with EV-70 and EV-94.  Unlike the remaining, EV-69 is acid-labile, which reduces its ability to colonize the gastrointestinal mucosa.  It has therefore been implicated in respiratory infections, and in rare occasions in [[CNS infection]].  This characteristic of EV-68 sets it apart from other enteroviruses, in what deals with its [[pathogenesis]] and infected cells.<ref name="pmid20872722">{{cite journal| author=Smura T, Ylipaasto P, Klemola P, Kaijalainen S, Kyllönen L, Sordi V et al.| title=Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in vitro: implications for pathogenesis. | journal=J Med Virol | year= 2010 | volume= 82 | issue= 11 | pages= 1940-9 | pmid=20872722 | doi=10.1002/jmv.21894 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20872722  }} </ref>
Enterovirus 68 belongs to the Human Enterovirus D species (HEV-D), along with EV-70 and EV-94.  Unlike the remaining, EV-69 is acid-labile, which reduces its ability to colonize the gastrointestinal mucosa.  It has therefore been implicated in respiratory infections, and in rare occasions in [[CNS infection]].  This characteristic of EV-68 sets it apart from other enteroviruses, in what deals with its [[pathogenesis]] and infected cells.<ref name="pmid20872722">{{cite journal| author=Smura T, Ylipaasto P, Klemola P, Kaijalainen S, Kyllönen L, Sordi V et al.| title=Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in vitro: implications for pathogenesis. | journal=J Med Virol | year= 2010 | volume= 82 | issue= 11 | pages= 1940-9 | pmid=20872722 | doi=10.1002/jmv.21894 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20872722  }} </ref>
Besides cells of the respiratory mucosa, EV-68 also shows tropism for [[leukocytes]], using the receptors that contain sialic-acid in these cells.<ref name="pmid15919894">{{cite journal| author=Vlasak M, Roivainen M, Reithmayer M, Goesler I, Laine P, Snyers L et al.| title=The minor receptor group of human rhinovirus (HRV) includes HRV23 and HRV25, but the presence of a lysine in the VP1 HI loop is not sufficient for receptor binding. | journal=J Virol | year= 2005 | volume= 79 | issue= 12 | pages= 7389-95 | pmid=15919894 | doi=10.1128/JVI.79.12.7389-7395.2005 | pmc=PMC1143622 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15919894  }} </ref>





Revision as of 12:47, 10 September 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Pathogenesis

Enterovirus 68 belongs to the Human Enterovirus D species (HEV-D), along with EV-70 and EV-94. Unlike the remaining, EV-69 is acid-labile, which reduces its ability to colonize the gastrointestinal mucosa. It has therefore been implicated in respiratory infections, and in rare occasions in CNS infection. This characteristic of EV-68 sets it apart from other enteroviruses, in what deals with its pathogenesis and infected cells.[1]

Besides cells of the respiratory mucosa, EV-68 also shows tropism for leukocytes, using the receptors that contain sialic-acid in these cells.[2]


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References

  1. Smura T, Ylipaasto P, Klemola P, Kaijalainen S, Kyllönen L, Sordi V; et al. (2010). "Cellular tropism of human enterovirus D species serotypes EV-94, EV-70, and EV-68 in vitro: implications for pathogenesis". J Med Virol. 82 (11): 1940–9. doi:10.1002/jmv.21894. PMID 20872722.
  2. Vlasak M, Roivainen M, Reithmayer M, Goesler I, Laine P, Snyers L; et al. (2005). "The minor receptor group of human rhinovirus (HRV) includes HRV23 and HRV25, but the presence of a lysine in the VP1 HI loop is not sufficient for receptor binding". J Virol. 79 (12): 7389–95. doi:10.1128/JVI.79.12.7389-7395.2005. PMC 1143622. PMID 15919894.