Tuberculosis future or investigational therapies: Difference between revisions

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Revision as of 15:02, 25 September 2014

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]

Any future regimen should satisfy the following principles.

It should not have more than a maximum duration of 6 months
The dosing schedule must be simple
The number of drugs in it should be ideally not more than 3-5 drug each from a different class
It should have minimum side effect profile so that we could have minimum monitoring
It should be effective against MDR, XDR and XXDR strains
It should be administered per orally
It should have minimum interaction with anti retroviral drugs.
It should have atleast one new class of drug

@@ Line 4: / Line 4: @@
 ==Overview==
 ==Future investigations==
-In future therapies the following questions must be pondered on.
-) How can we shorten chemotherapy?
+===Principles of future investigations===
+Any future regimen should satisfy the following principles.
-) How can the interval between the therapy reduced ?
+* It should not have more than a maximum duration of 6 months
+* The dosing schedule must be simple
-) How can new drugs be developed ?
+* The number of drugs in it should be ideally not more than 3-5 drug each from a different class
+* It should have minimum side effect profile so that we could have minimum monitoring
-) What is the best therapy for tuberculosis with HIV ?
+* It should be effective against MDR, XDR and XXDR strains
+* It should be administered per orally
-) Role of immunomodulation
+* It should have minimum interaction with anti retroviral drugs.
+* It should have atleast one new class of drug
 ===New drugs involved in clinical trial for treatment of tuberculosis===