Tuberculosis future or investigational therapies: Difference between revisions
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Revision as of 15:05, 25 September 2014
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Ammu Susheela, M.D. [2]
Overview
Future investigations
Principles of future investigations
Any future regimen should satisfy the following principles. [1]
- It should not have more than a maximum duration of 6 months
- The dosing schedule must be simple
- The number of drugs in it should be ideally not more than 3-5 drug each from a different class
- It should have minimum side effect profile so that we could have minimum monitoring
- It should be effective against MDR, XDR and XXDR strains
- It should be administered per orally
- It should have minimum interaction with anti retroviral drugs.
- It should have atleast one new class of drug
New drugs involved in clinical trial for treatment of tuberculosis
Drug | Phase | Class |
---|---|---|
Moxifloxacin | Phase III | Fluoroquinolone |
Linezolid | Phase II | Oxazolidinone |
AZD-5847 | Phase II | Oxazolidinone |
Sutezolid | Phase II | Oxazolidinone |
Clofazimine | Phase II | Riminophenazine |
SQ-109 | Phase II | Ethylenediamine |
PA-824 | Phase IIb | Nitroimidazole |
Delamanid | Phase III | Nitroimidazole |
Bedaquiline | Phase III | Diarylquinoline |
Data provided by WHO[2] |