Low density lipoprotein classification: Difference between revisions
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==Overview== | ==Overview== | ||
Prior approaches to the management of LDL plasma concentration aimed towards the classification of LDL concentrations and the treatment of subjects with [[dyslipidemia]] to a target LDL concentration. The National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III published in 2001 classified LDL concentrations into optimal, near optimal, borderline, high, and very high.<ref name="pmid11368702">{{cite journal| author=Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults| title=Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). | journal=JAMA | year= 2001 | volume= 285 | issue= 19 | pages= 2486-97 | pmid=11368702 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11368702 }} </ref> However, the latest 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommends the treatment of blood cholesterol to decrease atherosclerotic cardiovascular disease rather than to a target LDL cut-off value.<ref name="pmid24239923">{{cite journal| author=Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al.| title=2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 25 Pt B | pages= 2889-934 | pmid=24239923 | doi=10.1016/j.jacc.2013.11.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24239923 }} </ref> | Prior approaches to the management of LDL plasma concentration aimed towards the classification of LDL concentrations and the treatment of subjects with [[dyslipidemia]] to a target LDL concentration. The National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III published in 2001 classified LDL concentrations into optimal, near optimal, borderline high, high, and very high.<ref name="pmid11368702">{{cite journal| author=Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults| title=Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). | journal=JAMA | year= 2001 | volume= 285 | issue= 19 | pages= 2486-97 | pmid=11368702 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11368702 }} </ref> However, the latest 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommends the treatment of blood cholesterol to decrease atherosclerotic cardiovascular disease rather than to a target LDL cut-off value.<ref name="pmid24239923">{{cite journal| author=Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH et al.| title=2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. | journal=J Am Coll Cardiol | year= 2014 | volume= 63 | issue= 25 Pt B | pages= 2889-934 | pmid=24239923 | doi=10.1016/j.jacc.2013.11.002 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24239923 }} </ref> | ||
==Classification== | ==Classification== | ||
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{| style="cellpadding=0; cellspacing= 0; width: 600px;" | {| style="cellpadding=0; cellspacing= 0; width: 600px;" | ||
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| style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center |''' | | style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center |'''Concentration mg/dL'''||style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center | '''Concentration mmol/L''' || style="padding: 0 5px; font-size: 100%; background: #4682B4; color: #FFFFFF;" align=center |'''Interpretation''' | ||
|- | |- | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |<100 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |<100 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |<2.6 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |<2.6 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Optimal | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Optimal | ||
|- | |- | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |100 to 129 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |100 to 129 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |2.6 to 3.3 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |2.6 to 3.3 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Near optimal | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Near optimal | ||
|- | |- | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |130 to 159 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |130 to 159 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |3.3 to 4.1 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |3.3 to 4.1 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Borderline high | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Borderline high | ||
|- | |- | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |160 to 189 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |160 to 189 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |4.1 to 4.9 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |4.1 to 4.9 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |High | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |High | ||
|- | |- | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |>190 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |>190 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |>4.9 | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |>4.9 | ||
| style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Very high | | style="font-size: 100; padding: 0 5px; background: #B8B8B8" align=left |Very high | ||
|} | |} | ||
Revision as of 02:12, 28 September 2014
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Low Density Lipoprotein Microchapters |
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Low density lipoprotein classification On the Web |
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Risk calculators and risk factors for Low density lipoprotein classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]
Overview
Prior approaches to the management of LDL plasma concentration aimed towards the classification of LDL concentrations and the treatment of subjects with dyslipidemia to a target LDL concentration. The National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III published in 2001 classified LDL concentrations into optimal, near optimal, borderline high, high, and very high.[1] However, the latest 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Atherosclerotic Cardiovascular Risk in Adults recommends the treatment of blood cholesterol to decrease atherosclerotic cardiovascular disease rather than to a target LDL cut-off value.[2]
Classification
Shown below is the classification of the different concentrations of LDL according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel (ATP) III published in 2001.[1]
| Concentration mg/dL | Concentration mmol/L | Interpretation |
| <100 | <2.6 | Optimal |
| 100 to 129 | 2.6 to 3.3 | Near optimal |
| 130 to 159 | 3.3 to 4.1 | Borderline high |
| 160 to 189 | 4.1 to 4.9 | High |
| >190 | >4.9 | Very high |
References
- ↑ 1.0 1.1 Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001). "Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III)". JAMA. 285 (19): 2486–97. PMID 11368702.
- ↑ Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH; et al. (2014). "2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines". J Am Coll Cardiol. 63 (25 Pt B): 2889–934. doi:10.1016/j.jacc.2013.11.002. PMID 24239923.