Hepatocellular carcinoma causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Acute and chronic hepatic porphyrias (acute intermittent porphyria, porphyria cutanea tarda, hereditary coproporphyria, variegate porphyria) and tyrosinemia type I are risk factors for hepatocellular carcinoma. The diagnosis of an acute hepatic porphyria (AIP, HCP, VP) should be sought in patients with hepatocellular carcinoma without typical risk factors of hepatitis B or C, alcoholic liver cirrhosis or hemochromatosis. Both active and latent genetic carriers of acute hepatic porphyrias are at risk for this cancer, although latent genetic carriers have developed the cancer at a later age than those with classic symptoms. Patients with acute hepatic porphyrias should be monitored for hepatocellular carcinoma.

Drug Side Effect

Drospirenone and Ethinyl estradiol, Norethindrone acetate and Ethinyl estradiol, Norgestimate and Ethinyl estradiol

References

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