|indication=[[acne]], for relief of [[itching]], irritation, redness and scaling assoicated with [[psoriasis]], [[eczema]] and [[seborrheic dermatitis]]
|indication=[[acne]], for relief of [[itching]], irritation, redness and scaling assoicated with [[psoriasis]], [[eczema]] and [[seborrheic dermatitis]]
Salicylic acid has been shown to work through several different pathways. It produces its anti-inflammatory effects via suppressing the activity of cyclooxygenase (COX), an enzyme that is responsible for the production of pro-inflammatory mediators such as the prostaglandins. It does this not by direct inhibition of COX like most other non-steroidal anti-inflammatory drugs (NSAIDs) but instead by suppression of the expression of the enzyme (via a yet-unelucidated mechanism).<ref name=Science connections>{{cite web | title = American chemical society | url =http://www.cas.org/news/insights/science-connections/aspirin }}</ref> Salicylic acid has also been shown to activate adenosine monophosphate-activated protein kinase (AMPK), and it is thought that this action may play a role in the anticancer effects of the compound and its prodrugs aspirin and salsalate. In addition, the antidiabetic effects of salicylic acid are likely mediated by AMPK activation primarily through allosteric conformational change that increases levels of phosphorylation.<ref name="pmidPMID 22517326">{{cite journal| author=Hawley SA, Fullerton MD, Ross FA, Schertzer JD, Chevtzoff C, Walker KJ et al.| title=The ancient drug salicylate directly activates AMP-activated protein kinase. | journal=Science | year= 2012 | volume= 336 | issue= 6083 | pages= 918-22 | pmid=PMID 22517326 | doi=10.1126/science.1215327 | pmc=PMC3399766 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22517326 }} </ref> Salicylic acid also uncouples oxidative phosphorylation, which leads to increased ADP:ATP and AMP:ATP ratios in the cell. As a consequence, salicylic acid may alter AMPK activity and subsequently exert its anti-diabetic properties through altered energy status of the cell. Even in AMPK knock-out mice, however, there is an anti-diabetic effect, demonstrating that there is at least one additional, yet-unidentified action of the compound.<ref name=New Scientist>{{cite web | title = New scientist | url =http://www.newscientist.com/article/dn21718-clues-to-aspirins-anticancer-effects-revealed.html#.VJEfNyvF_Mc }}</ref>
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Overview
Salicylic acid is a anti acne agent that is FDA approved for the treatment of acne, for relief of itching, irritation, redness and scaling assoicated with psoriasis, eczema and seborrheic dermatitis. Common adverse reactions include hypersensitivity reaction, salicylate toxicity.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
FOR THE TREATMENT OF ACNE
HELPS KEEP SKIN CLEAR OF NEW ACNE BLEMISHES
For relief of itching, irritation, redness and scaling assoicated with psoriasis, eczema and seborrheic dermatitis.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Acne vulgaris
Apply TOPICALLY in concentrations of 0.5% to 10%
Disorder of skin, Hyperkeratotic: gel, apply TOPICALLY to the affected area and occlude the area at night.
Disorder of skin, Hyperkeratotic
shampoo, wet hair and apply TOPICALLY to the scalp, work into a lather and rinse; repeat the treatment as needed until the condition clears [5]
Psoriasis
Apply TOPICALLY in concentrations of 3% to 6%
Removal of wart
Apply TOPICALLY once or twice daily in concentrations of 5% to 40% for up to 12 weeks
Non–Guideline-Supported Use
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Salicylic acid in adult patients.
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding FDA-Labeled Use of Salicylic acid in pediatric patients.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
Condition1
Developed by:
Class of Recommendation:
Strength of Evidence:
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Guideline-Supported Use of Salicylic acid in pediatric patients.
Non–Guideline-Supported Use
Condition1
Dosing Information
Dosage
Condition2
There is limited information regarding Off-Label Non–Guideline-Supported Use of Salicylic acid in pediatric patients.
Contraindications
Condition1
Warnings
For external use only.
Avoid contact with eyes. If contact occurs, rinse thoroughly with water.
Do not use without consulting a doctor if the condition appears over a large portion of hte body.
If condition worsens, or does not improve after using as directed, consult physician.
Do not use for prolonged periods without consulting a doctor.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Clinical Trial Experience of Salicylic acid in the drug label.
Postmarketing Experience
There is limited information regarding Postmarketing Experience of Salicylic acid in the drug label.
Drug Interactions
There is limited information regarding Salicylic acid Drug Interactions in the drug label.
