Malathion: Difference between revisions
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*(5)If lice are still present after 7 - 9 days, repeat with a second application of Malathion Lotion. | *(5)If lice are still present after 7 - 9 days, repeat with a second application of Malathion Lotion. | ||
*(6)Further treatment is generally not necessary. Other family members should be evaluated by a physician to determine if infested, and if so, receive treatment. | *(6)Further treatment is generally not necessary. Other family members should be evaluated by a physician to determine if infested, and if so, receive treatment. | ||
|offLabelAdultGuideSupport======Infestation by Phthirus pubis===== | |||
*Dosage: Malathion 0.5% lotion applied for 8 to 12 hours and washed off<ref>{{cite web|url=http://www.cdc.gov/mmwr/pdf/rr/rr5912.pdf|title=CDC Guideline for Pediculosis pubis}}</ref> | |||
|offLabelAdultNoGuideSupport======Infestation by Phthirus pubis===== | |||
|offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Malathion in pediatric patients. | |offLabelPedGuideSupport=There is limited information regarding <i>Off-Label Guideline-Supported Use</i> of Malathion in pediatric patients. | ||
|offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Malathion in pediatric patients. | |offLabelPedNoGuideSupport=There is limited information regarding <i>Off-Label Non–Guideline-Supported Use</i> of Malathion in pediatric patients. | ||
Revision as of 15:47, 29 December 2014
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]
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Overview
Malathion is an organophosphate that is FDA approved for the treatment of pediculus humanus capitis (Pediculus humanus capitis). Common adverse reactions include application site irritation, skin irritation.
Adult Indications and Dosage
FDA-Labeled Indications and Dosage (Adult)
- (1)Apply Malathion Lotion on dry hair in amount just sufficient to thoroughly wet the hair and scalp. Pay particular attention to the back of the head and neck while applying Malathion lotion. Wash hands after applying to scalp.
- (2)Allow hair to dry naturally - use no electric heat source, and allow hair to remain uncovered.
- (3)After 8 to 12 hours, the hair should be shampooed.
- (4)Rinse and use a fine - toothed (nit) comb to remove dead lice and eggs.
- (5)If lice are still present after 7 - 9 days, repeat with a second application of Malathion Lotion.
- (6)Further treatment is generally not necessary. Other family members should be evaluated by a physician to determine if infested, and if so, receive treatment.
Off-Label Use and Dosage (Adult)
Guideline-Supported Use
Infestation by Phthirus pubis
- Dosage: Malathion 0.5% lotion applied for 8 to 12 hours and washed off[1]
Non–Guideline-Supported Use
Infestation by Phthirus pubis
Pediatric Indications and Dosage
FDA-Labeled Indications and Dosage (Pediatric)
There is limited information regarding Malathion FDA-Labeled Indications and Dosage (Pediatric) in the drug label.
Off-Label Use and Dosage (Pediatric)
Guideline-Supported Use
There is limited information regarding Off-Label Guideline-Supported Use of Malathion in pediatric patients.
Non–Guideline-Supported Use
There is limited information regarding Off-Label Non–Guideline-Supported Use of Malathion in pediatric patients.
Contraindications
There is limited information regarding Malathion Contraindications in the drug label.
Warnings
There is limited information regarding Malathion Warnings' in the drug label.
Adverse Reactions
Clinical Trials Experience
There is limited information regarding Malathion Clinical Trials Experience in the drug label.
Postmarketing Experience
There is limited information regarding Malathion Postmarketing Experience in the drug label.
Drug Interactions
There is limited information regarding Malathion Drug Interactions in the drug label.
Use in Specific Populations
Pregnancy
Pregnancy Category (FDA):
There is no FDA guidance on usage of Malathion in women who are pregnant.
Pregnancy Category (AUS):
There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Malathion in women who are pregnant.
Labor and Delivery
There is no FDA guidance on use of Malathion during labor and delivery.
Nursing Mothers
There is no FDA guidance on the use of Malathion in women who are nursing.
Pediatric Use
There is no FDA guidance on the use of Malathion in pediatric settings.
Geriatic Use
There is no FDA guidance on the use of Malathion in geriatric settings.
Gender
There is no FDA guidance on the use of Malathion with respect to specific gender populations.
Race
There is no FDA guidance on the use of Malathion with respect to specific racial populations.
Renal Impairment
There is no FDA guidance on the use of Malathion in patients with renal impairment.
Hepatic Impairment
There is no FDA guidance on the use of Malathion in patients with hepatic impairment.
Females of Reproductive Potential and Males
There is no FDA guidance on the use of Malathion in women of reproductive potentials and males.
Immunocompromised Patients
There is no FDA guidance one the use of Malathion in patients who are immunocompromised.
Administration and Monitoring
Administration
There is limited information regarding Malathion Administration in the drug label.
Monitoring
There is limited information regarding Malathion Monitoring in the drug label.
IV Compatibility
There is limited information regarding the compatibility of Malathion and IV administrations.
Overdosage
There is limited information regarding Malathion overdosage. If you suspect drug poisoning or overdose, please contact the National Poison Help hotline (1-800-222-1222) immediately.
Pharmacology
There is limited information regarding Malathion Pharmacology in the drug label.
Mechanism of Action
There is limited information regarding Malathion Mechanism of Action in the drug label.
Structure
There is limited information regarding Malathion Structure in the drug label.
Pharmacodynamics
There is limited information regarding Malathion Pharmacodynamics in the drug label.
Pharmacokinetics
There is limited information regarding Malathion Pharmacokinetics in the drug label.
Nonclinical Toxicology
There is limited information regarding Malathion Nonclinical Toxicology in the drug label.
Clinical Studies
There is limited information regarding Malathion Clinical Studies in the drug label.
How Supplied
There is limited information regarding Malathion How Supplied in the drug label.
Storage
There is limited information regarding Malathion Storage in the drug label.
Images
Drug Images
{{#ask: Page Name::Malathion |?Pill Name |?Drug Name |?Pill Ingred |?Pill Imprint |?Pill Dosage |?Pill Color |?Pill Shape |?Pill Size (mm) |?Pill Scoring |?NDC |?Drug Author |format=template |template=DrugPageImages |mainlabel=- |sort=Pill Name }}
Package and Label Display Panel
{{#ask: Label Page::Malathion |?Label Name |format=template |template=DrugLabelImages |mainlabel=- |sort=Label Page }}
Patient Counseling Information
There is limited information regarding Malathion Patient Counseling Information in the drug label.
Precautions with Alcohol
Alcohol-Malathion interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.
Brand Names
There is limited information regarding Malathion Brand Names in the drug label.
Look-Alike Drug Names
There is limited information regarding Malathion Look-Alike Drug Names in the drug label.
Drug Shortage Status
Price
References
The contents of this FDA label are provided by the National Library of Medicine.
Malathion is an organophosphate parasympathomimetic which binds irreversibly to cholinesterase. Malathion is an insecticide of relatively low human toxicity.
In the former USSR it was known as carbophos, in New Zealand and Australia as maldison and in South Africa as mercaptothion. [1]
Risks
Malathion breaks down into malaoxon, which is 60 times more toxic than malathion. For this reason, if malathion is used in or somehow enters an indoor environment, as it breaks down into malaoxon, it can seriously and chronically poison the occupants living or working in this environment. Malathion present in untreated water is converted to malaoxon during the chlorination phase of water treatment, so malathion should not be used in waters that may be used as a source for drinking water, or any upstream waters.
In 1976, numerous malaria workers in Pakistan were poisoned by isomalathion, a common impurity in malathion,[2] which is capable of inhibiting carboxyesterase enzymes in those exposed to it; the original toxicity evaluation for malathion had not anticipated isomalathion coexposure.
Clinical uses
Malathion is used as a treatment for head lice, body lice and scabies. It effectively kills both the eggs and the adult lice.
Instances of use
In the US, it is the most commonly used organophosphate insecticide. [3]
Malathion was used in the 1980s in California to combat the Mediterranean Fruit Fly. This was accomplished on a wide scale by the near weekly aerial spraying of suburban communities for a period of several months. Formations of three or four agricultural helicopters would overfly suburban portions of San Bernardino county releasing a mixture of malathion and corn syrup, the corn syrup being a bait for the fruit flies. Malathion has also been used to combat the Mediterranean Fruit Fly in Australia.[4]
Malathion was sprayed in many cities to combat West Nile virus. In the Fall of 1999 and the Spring of 2000, Long Island and the five boroughs of New York City were sprayed with malathion. Use of the insecticide has been blamed for large lobster die-off in Long Island Sound.[5]
Manitoba, Province of Canada, ordered the city of Winnipeg, Manitoba to be sprayed in July 2005 as part of the West Nile virus campaign. Prior to this, Malathion was used over the last couple of decades on regular basis during summer months to kill nuisance mosquitos, but homeowners were allowed to exempt their properties if they chose. Today, Winnipeg is the only major city in Canada with an ongoing Malathion nuisance adult mosquito control program.
Malathion is also used in conjunction with diesel to fog an area where there are plenty of mosquitoes. By diluting the mixture, it becomes much weaker. It is possible to dilute the mixture to the point where mosquitoes are not killed, but become more resistant to the mixture, making it less effective in subsequent foggings.
See also
References
- ↑ "alanwood.net". Retrieved 2007-09-16.
- ↑ Baker EL, Warren M, Zack M; et al. (1978). "Epidemic malathion poisoning in Pakistan malaria workers". Lancet. 1 (8054): 31–4. PMID 74508.
- ↑ Bonner MR, Coble J, Blair A; et al. (2007). "Malathion Exposure and the Incidence of Cancer in the Agricultural Health Study". doi:10.1093/aje/kwm182. PMID 17720683.
- ↑ Edwards JW, Lee SG, Heath LM, Pisaniello DL (2007). "Worker exposure and a risk assessment of malathion and fenthion used in the control of Mediterranean fruit fly in South Australia". Environ. Res. 103 (1): 38–45. doi:10.1016/j.envres.2006.06.001. PMID 16914134.
- ↑ http://www.seagrant.sunysb.edu/LILobsters/Oct04Meeting/summaries/LISLISummary-Pesticides.pdf
cs:Malation de:Malathion fa:مالاتیون nl:Malathion