Nandrolone

Nandrolone
Black Box Warning
Adult Indications & Dosage
Pediatric Indications & Dosage
Contraindications
Warnings & Precautions
Adverse Reactions
Drug Interactions
Use in Specific Populations
Administration & Monitoring
Overdosage
Pharmacology
Clinical Studies
How Supplied
Images
Patient Counseling Information
Precautions with Alcohol
Brand Names
Look-Alike Names

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Deepika Beereddy, MBBS [2]

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Black Box Warning

ConditionName: See full prescribing information for complete Boxed Warning. ConditionName: Content

Overview

Nandrolone is an anabolic steroid, endocrine-metabolic agent that is FDA approved for the treatment of anemia of chronic renal failure. There is a Black Box Warning for this drug as shown here. Common adverse reactions include acne in women and prepubertal boys, female hirsutism, male pattern alopecia in women, gynecomastia in men, diarrhea, nausea, vomiting, insomnia, depression, excitability, atrophy of testis, postpubertal males, erectile dysfunction, erection finding- increased frequency, hypertrophy of clitoris, irregular periods, decreased or increased libido in men or women, priapism, enlargement penis in prepubertal males, testicular hypofunction, deepening in voice in women, drug habituation.

Adult Indications and Dosage

FDA-Labeled Indications and Dosage (Adult)

Anemia of chronic renal failure

• Nandrolone decanoate is indicated for the management of the anemia of renal insufficiency and has been shown to increase hemoglobin and red cell mass. Surgically induced anephric patients have been reported to be less responsive.

• Dosing Information

• Nandrolone decanoate injection is intended for deep intramuscular injection only, into the gluteal muscle preferably. Dosage should be based on therapeutic response and consideration of the benefit to risk ratio. Duration of therapy will depend on the response of the condition and the appearance of adverse reactions. If possible, therapy should be intermittent. Nandrolone decanoate should be regarded as adjunctive therapy and adequate quantities of nutrients should be consumed in order to obtain maximal therapeutic effects. For example, when it is used in the treatment of refractory anemia, adequate iron intake is required for a maximal response.

• 1) Both nandrolone decanoate is administered by deep intramuscular injection. For nandrolone decanoate, the recommended dose for women is 50 to 100 milligrams per week and 100 to 200 milligrams per week for men [13].

2) Prior to the availability of recombinant erythropoietin (epoetin), nandrolone decanoate was widely used in the treatment of ANEMIA in patients with chronic renal failure in doses of 100 to 200 milligrams intramuscularly weekly [9][8][11][10][12][3]. Responses were best in patients who were well-nourished and receiving adequate dialysis. 3) Recombinant epoetin is now usually preferred over androgens for initial non-transfusional therapy in these patients. The use of lower doses of epoetin in combination with nandrolone has, however, been investigated due to financial constraints. In one study, a greater increase in hematocrit was reported with combined low-dose recombinant epoetin (2000 units three times weekly) plus nandrolone decanoate (100 milligrams weekly) as compared to epoetin alone in the same doses in male hemodialysis patients. Nandrolone therapy was started simultaneously with epoetin [6]. However, in another combination study, no additional benefit was observed when nandrolone was started at least 2 months prior to epoetin [7]. Further studies investigating this combination are needed.

Condition2

• Dosing Information

• Dosage

Condition3

• Dosing Information

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Condition4

• Dosing Information

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Off-Label Use and Dosage (Adult)

Guideline-Supported Use

• There is limited information regarding Off-Label Guideline-Supported Use of Nandrolone in adult patients.

Non–Guideline-Supported Use

• There is limited information regarding Off-Label Non–Guideline-Supported Use of Nandrolone in adult patients.

Pediatric Indications and Dosage

FDA-Labeled Indications and Dosage (Pediatric)

Anemia of chronic renal failure

• Dosing Information

• The safety and effectiveness in children less than 2 years of age has not been established.
• In children 2 to 13 years of age, the dose of nandrolone decanoate is 25 to 50 milligrams every 3 to 4 weeks.

Off-Label Use and Dosage (Pediatric)

Guideline-Supported Use

• There is limited information regarding Off-Label Guideline-Supported Use of Nandrolone in pediatric patients.

Non–Guideline-Supported Use

• There is limited information regarding Off-Label Non–Guideline-Supported Use of Nandrolone in pediatric patients.

Contraindications

• Male patients with carcinoma of the breast or with known or suspected carcinoma of the prostate.
• Carcinoma of the breast in females with hypercalcemia: androgenic anabolic steroids may stimulate osteolytic resorption of bones.
• Pregnancy, because of masculinization of the fetus.
• Nephrosis or the nephrotic phase of nephritis.

Warnings

ConditionName: See full prescribing information for complete Boxed Warning. ConditionName: Content

• PELIOSIS HEPATIS, A CONDITION IN WHICH LIVER AND SOMETIMES SPLENIC TISSUE IS REPLACED WITH BLOOD-FILLED CYSTS, HAS BEEN REPORTED IN PATIENTS RECEIVING ANDROGENIC ANABOLIC STEROID THERAPY. THESE CYSTS ARE SOMETIMES PRESENT WITH MINIMAL HEPATIC DYSFUNCTION, BUT AT OTHER TIMES THEY HAVE BEEN ASSOCIATED WITH LIVER FAILURE. THEY ARE OFTEN NOT RECOGNIZED UNTIL LIFE-THREATENING LIVER FAILURE OR INTRA-ABDOMINAL HEMORRHAGE DEVELOPS. WITHDRAWAL OF DRUG USUALLY RESULTS IN COMPLETE DISAPPEARANCE OF LESIONS. LIVER CELL TUMORS ARE ALSO REPORTED. MOST OFTEN THESE TUMORS ARE BENIGN AND ANDROGEN-DEPENDENT, BUT FATAL MALIGNANT TUMORS HAVE BEEN REPORTED. WITHDRAWAL OF DRUG OFTEN RESULTS IN REGRESSION OR CESSATION OF PROGRESSION OF THE TUMOR. HOWEVER, HEPATIC TUMORS ASSOCIATED WITH ANDROGENS OR ANABOLIC STEROIDS ARE MUCH MORE VASCULAR THAN OTHER HEPATIC TUMORS AND MAY BE SILENT UNTIL LIFE-THREATENING INTRA-ABDOMINAL HEMORRHAGE DEVELOPS. BLOOD LIPID CHANGES THAT ARE KNOWN TO BE ASSOCIATED WITH INCREASED RISK OF ATHEROSCLEROSIS ARE SEEN IN PATIENTS TREATED WITH ANDROGENS AND ANABOLIC STEROIDS. THESE CHANGES INCLUDE DECREASED HIGH-DENSITY LIPOPROTEIN AND SOMETIMES INCREASED LOW-DENSITY LIPOPROTEIN. THE CHANGES MAY BE VERY MARKED AND COULD HAVE A SERIOUS IMPACT ON THE RISK OF ATHEROSCLEROSIS AND CORONARY ARTERY DISEASE.

• Hypercalcemia may develop both spontaneously and as a result of androgen therapy in women with disseminated breast carcinoma. If it develops while on this agent, the drug should be discontinued. Caution is required in administering these agents to patients with cardiac, renal or hepatic disease. Cholestatic jaundice is associated with therapeutic use of anabolic and androgenic steroids. Edema may occur occasionally with or without congestive heart failure. Concomitant administration of adrenal steroids or ACTH may add to the edema. In children, anabolic steroid treatment may accelerate bone maturation without producing compensatory gain in linear growth. This adverse effect may result in compromised adult stature. The younger the child the greater the risk of compromising final mature height. The effect on bone maturation should be monitored by assessing bone age of the wrist and hand every six months. This drug has not been shown to be safe and effective for the enhancement of athletic performance. Because of the potential risk of serious adverse health effects, this drug should not be used for such purpose.

Precautions

General

• Women should be observed for signs of virilization (deepening of the voice, hirsutism, acne, clitorimegaly and menstrual irregularities). Discontinuation of drug therapy at the time of evidence of mild virilism is necessary to prevent irreversible virilization. Such virilization is usual following anabolic steroid use in high doses. The insulin or oral hypoglycemic dosage may need adjustment in diabetic patients who receive anabolic steroids.

Information for Patients

• The physician should instruct patients to report any of the following side effects of androgenic anabolic steroids: Hoarseness, acne, changes in menstrual periods, more hair on the face, nausea, vomiting, changes in skin color, or ankle swelling.

Laboratory Tests

Women with disseminated breast carcinoma should have frequent determination of urine and serum calcium levels during the course of anabolic therapy (see WARNINGS section). If children are treated, periodic (every six months) X-ray examinations of bone age should be made during treatment to determine the rate of bone maturation and the effects of anabolic therapy on the epiphyseal centers. Hemoglobin and hematocrit should be checked periodically for polycythemia in patients who are receiving high doses of anabolic steroids. Serum lipids and high-density lipoprotein cholesterol should be determined periodically. Because of the hepatotoxicity associated with the use of 17-alpha-alkylated anabolic steroids, liver function tests should be obtained periodically.

Adverse Reactions

Clinical Trials Experience

Hepatic: Hepatocellular neoplasms and peliosis hepatis have been reported in association with long-term androgenic anabolic steroid therapy (see WARNINGS section).

Genitourinary System: In men.

   Prepubertal: Phallic enlargement and increased frequency of erections.
   Postpubertal: Inhibition of testicular function, testicular atrophy and oligospermia, impotence, chronic priapism, epididymitis and bladder irritability.

In women: Clitoral enlargement, menstrual irregularities. In both sexes: Increased or decreased libido.

CNS: Habituation, excitation, insomnia, depression.

Gastrointestinal: Nausea, vomiting, diarrhea.

Hematologic: Bleeding in patients on concomitant anticoagulant therapy (see PRECAUTIONS, Drug Interactions).

Breast: Gynecomastia.

Larynx: Deepening of the voice in women.

Hair: Hirsutism and male pattern of baldness in women.

Skin: Acne (especially in women and prepubertal boys.)

Skeletal: Premature closure of epiphyses in children (see PRECAUTIONS, Pediatric use).

Fluid and Electrolytes: Edema, retention of serum electrolytes (sodium, chloride, potassium, phosphate, calcium).

Metabolic/Endocrine: Decreased glucose tolerance (see PRECAUTIONS, General), increased serum levels of low-density lipoprotein and decreased levels of high-density lipoprotein (see PRECAUTIONS, Laboratory tests), increased creatine and creatinine excretion, increased serum levels of creatinine phosphokinase (CPK). Some virilizing changes in women are irreversible even after prompt discontinuance of therapy and are not prevented by concomitant use of estrogens (see PRECAUTIONS).

DRUG ABUSE AND DEPENDENCE

• Nandrolone decanoate injection is classified as a Schedule III controlled substance under the Anabolic Steroids Control Act of 1990.

Postmarketing Experience

There is limited information regarding Postmarketing Experience of Nandrolone in the drug label.

Body as a Whole

Cardiovascular

Digestive

Endocrine

Hematologic and Lymphatic

Metabolic and Nutritional

Musculoskeletal

Neurologic

Respiratory

Skin and Hypersensitivy Reactions

Special Senses

Urogenital

Miscellaneous

Drug Interactions

Anticoagulants. Anabolic steroids may increase sensitivity to oral anticoagulants. Dosage of the anticoagulant may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level. Patients receiving oral anticoagulant therapy require close monitoring, especially when anabolic steroids are started or stopped.

DRUG & OR LABORATORY TEST INTERACTIONS

Anabolic steroid therapy may decrease thyroxine-binding globulin resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged. Anabolic steroids may cause an increase in prothrombin time.

Use in Specific Populations

Pregnancy

Pregnancy Category (FDA): X Pregnancy Category X.

See CONTRAINDICATIONS section.
Pregnancy Category (AUS):

• Australian Drug Evaluation Committee (ADEC) Pregnancy Category

There is no Australian Drug Evaluation Committee (ADEC) guidance on usage of Nandrolone in women who are pregnant.

Labor and Delivery

There is no FDA guidance on use of Nandrolone during labor and delivery.

Nursing Mothers

• It is not known whether anabolic steroids are excreted in human milk. Many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from anabolic steroids, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.

Pediatric Use

• The safety and efficacy of nandrolone decanoate in children with metastatic breast cancer (rarely found) has not been established. Anabolic agents may accelerate epiphyseal maturation more rapidly than linear growth in children, and the effect may continue for six months after the drug has been stopped. Therefore, therapy should be monitored by X-ray studies at six month intervals in order to avoid the risk of compromising the adult height.

Geriatic Use

There is no FDA guidance on the use of Nandrolone with respect to geriatric patients.

Gender

There is no FDA guidance on the use of Nandrolone with respect to specific gender populations.

Race

There is no FDA guidance on the use of Nandrolone with respect to specific racial populations.

Renal Impairment

There is no FDA guidance on the use of Nandrolone in patients with renal impairment.

Hepatic Impairment

There is no FDA guidance on the use of Nandrolone in patients with hepatic impairment.

Females of Reproductive Potential and Males

There is no FDA guidance on the use of Nandrolone in women of reproductive potentials and males.

Immunocompromised Patients

There is no FDA guidance one the use of Nandrolone in patients who are immunocompromised.

Administration and Monitoring

Administration

• Nandrolone decanoate injection is intended for deep intramuscular injection only, into the gluteal muscle preferably. Dosage should be based on therapeutic response and consideration of the benefit to risk ratio. Duration of therapy will depend on the response of the condition and the appearance of adverse reactions. If possible, therapy should be intermittent. Nandrolone decanoate should be regarded as adjunctive therapy and adequate quantities of nutrients should be consumed in order to obtain maximal therapeutic effects. For example, when it is used in the treatment of refractory anemia, adequate iron intake is required for a maximal response.

Monitoring

There is limited information regarding Monitoring of Nandrolone in the drug label.

• Description

IV Compatibility

There is limited information regarding IV Compatibility of Nandrolone in the drug label.

Overdosage

Acute Overdose

Signs and Symptoms

• Description

Management

• Description

Chronic Overdose

There is limited information regarding Chronic Overdose of Nandrolone in the drug label.

Pharmacology

Mechanism of Action

• Anabolic steroids are synthetic derivatives of testosterone. Certain clinical effects and adverse reactions demonstrate the androgenic properties of this class of drugs. Complete dissociation of anabolic and androgenic effects has not been achieved. The actions of anabolic steroids are therefore similar to those of male sex hormones with the possibility of causing serious disturbances of growth and sexual development if given to young children. Anabolic steroids suppress the gonadotropic functions of the pituitary and may exert a direct effect upon the testis. Anabolic steroids have been reported to increase low-density lipoproteins and decrease high-density lipoproteins. These changes revert to normal on discontinuation of treatment.

Structure

A sterile oleaginous solution containing per mL: Nandrolone Decanoate 200 mg with Benzyl Alcohol 5% as solubilizer/preservative, in Sesame Oil q.s. Nandrolone decanoate (C28H44O3) occurs as a fine, white to creamy white, crystalline powder. It is odorless, or may have a slight odor. Nandrolone decanoate is soluble in chloroform, in alcohol, in acetone, and in vegetable oils. It is practically insoluble in water.

Pharmacodynamics

There is limited information regarding Pharmacodynamics of Nandrolone in the drug label.

Pharmacokinetics

There is limited information regarding Pharmacokinetics of Nandrolone in the drug label.

Nonclinical Toxicology

Carcinogenesis, Mutagenesis, Impairment of Fertility

Nandrolone decanoate has not been tested in laboratory animals for carcinogenic or mutagenic effects. Liver cell tumors have been reported in patients receiving androgenic anabolic steroid therapy (see WARNINGS section). Geriatric patients treated with anabolics may be at an increased risk for prostatic hypertrophy and prostatic carcinoma.

Clinical Studies

There is limited information regarding Clinical Studies of Nandrolone in the drug label.

How Supplied

• Nandrolone Decanoate Injection USP, 200 mg per mL is available in vials of 1 mL, in cartons of 20.

Storage

• Store at 20° to 25°C (68° to 77°F) [See USP Controlled Room Temperature].

• PROTECT FROM LIGHT. Store in carton until contents are used.

Images

Drug Images

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Package and Label Display Panel

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Patient Counseling Information

There is limited information regarding Patient Counseling Information of Nandrolone in the drug label.

Precautions with Alcohol

• Alcohol-Nandrolone interaction has not been established. Talk to your doctor about the effects of taking alcohol with this medication.

Brand Names

Deca-Durabolin, Hybolin Decanoate.

Look-Alike Drug Names

• A® — B®

Drug Shortage Status

Price

References

The contents of this FDA label are provided by the National Library of Medicine.

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