Dyspnea causes

Dyspnea Microchapters
Patient Information
Overview
Pathophysiology
Causes
Differentiating Dyspnea from other Diseases

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

• Acute heart failure
• Acute papillary muscle rupture
• Cardiac tamponade
• Foreign body aspiration
• Spontaneous pneumothorax
• H. influenza epiglottitis
• Bronchospasm
• Pulmonary edema

Causes by Organ System

Cardiovascular	Acute coronary syndromes, Angina Pectoris, Aortic arch anomalies, Aortic dissection, Aortic regurgitation, Aortic stenosis, Arrhythmia, Atrial fibrillation, Atrioseptal defect, Beriberi heart disease, Biventricular heart failure, Bicalutamide, Bland-White-Garland Syndrome, Cardiac disease in pregnancy, Cardiac failure, Cardiomegaly, Cardiomyopathy, Cholesterol pericarditis, Congenital heart disease, Congestive heart failure, Continuous murmur, Cor Pulmonale, Coronary artery disease, Coronary artery fistula, Diseases of the pericardium such as Cardiac tamponade, Constrictive pericarditis orPericardial effusion, Ebstein's anomaly of the tricuspid valve, Endocarditis, Endomyocardial fibrosis, Heart failure, Hypertension, Hypertensive heart disease, Hypertrophic cardiomyopathy, Inappropriate sinus tachycardia, Irregular heart rhythms, Ischaemic heart disease, Levo-Transposition of the great arteries, Loeffler's Endocarditis, Malignant hypertension, Mitral regurgitation, Mitral stenosis, Myocardial infarction, STEMI, Patent ductus arteriosus, Pericardial effusion, pericardial constriction, Perimyocarditis, Pulmonary arteriovenous malformation, Pulmonary edema, Pulmonary embolism, Pulmonary hypertension, Pulmonary stenosis, Right ventricular failure, Shock, Shock lung, Sipuleucel-T, Tetralogy of Fallot, Tricuspid stenosis, Tumors of the myocardium, Valvular heart disease, Ventricular septal defect
Chemical / poisoning	Intoxication (carbon monoxide, cyanide)
Dermatologic	No underlying causes
Drug Side Effect	Acetaminophen and Oxycodone, Acetylcysteine, Aldesleukin, Amphotericin B, Amyl nitrite, Aztreonam, Basiliximab, Beta-blockers, Betazole, Bleomycin , Bromocriptine, Butorphanol, Carfilzomib, Caspofungin, cefoxitin sodium, Cladosporium, Clomifene, caspofungin acetate, Crizotinib, Cefaclor, Daptomycin, Denileukin diftitox, Desmopressin, Disulfiram, Drugs, Dornase Alfa, Efavirenz, Enzalutamide, Ephedrine, Estramustine, Febuxostat, Fulvestrant, Gemcitabine, Gemeprost, Glatiramer acetate, Goserelin, Hydroxocobalamin, Iloprost, Ketorolac, Leflunomide, Lenalidomide, Letrozole, Levothyroxine, Megestrol, Mercury, Meropenem, Mesalamine, Methyl isocyanate, Mifepristone, Minocycline hydrochloride, Moxifloxacin ophthalmic, Nabumetone, Naltrexone, Niacin, Oxcarbazepine, Panitumumab, Polidocanol, Polyethylene glycol-electrolyte solution (PEG-ES), Rizatriptan, Ropinirole, Romidepsin, Sertraline, Sorafenib, Sunitinib, Thalidomide, Tiagabine, Tocilizumab, Topiramate, Tretinoin, Zonisamide,Zoledronate
Ear Nose Throat	Glottic edema, Sleep apnea syndrome, Empty nose syndrome
Endocrine	Diabetic coma, Goiter, Hyperthyroidism, Hypothyroidism, Myxoma
Environmental	No underlying causes
Gastroenterologic	Abdominal masses, Cirrhosis, Diverticulosis, Esophageal cancer, Esophageal diseases with tracheal compression, Gastroesophageal reflux, Intussusception
Genetic	No underlying causes
Hematologic	Acute myeloid leukemia, Acute promyelocytic leukemia, Anemia, Blood transfusion, Erdheim-Chester disease, Histiocytosis X, Iron deficiency anemia, Leukemia, Lymphoma, Megaloblastic anemia
Iatrogenic	Barium, Bronchoscopy, Chest tube, Empty nose syndrome, Radiation pneumonitis
Infectious Disease	Acute bronchitis, AIDS, Anthrax, Aspergillus clavatus, Atypical pneumonia, CMV Pneumonitis, Community-acquired pneumonia, Croup, Ehrlichiosis , Sepsis, Micropolyspora faeni, Miliary tuberculosis, Pleural empyema, Pneumonia, Respiratory tract infection, Sepsis
Musculoskeletal / Ortho	Kyphoscoliosis, Polyradiculitis
Neurologic	Amyotrophic lateral sclerosis (ALS), Brain stem infarction, Eaton-Lambert syndrome, Encephalitis, Guillain-Barre Syndrome, Multiple sclerosis, Myasthenia gravis, Neuromuscular disease, Parsonage-Turner syndrome, Phrenic nerve paralysis
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	Amniotic fluid embolism, Cardiac disease in pregnancy
Oncologic	Acute myeloid leukemia, Acute promyelocytic leukemia, Bronchial tumors, Bronchogenic carcinoma, Leukemia, Lung cancer, Lymphangitic metastases, Lymphoma, Malignant mesothelioma, Mediastinal tumors, Tracheal tumors, Tumors of the myocardium
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	Anxiety disorders, Hysteria, Panic attacks
Pulmonary	Acute bronchitis , Acute chest syndrome, Acute tracheobronchitis, Air-conditioner lung, Alpha 1-antitrypsin deficiency, Asbestosis, Aspiration, Asthma, Atelectasis, Bird breeder's lung, Bird fancier's lung, Bronchial asthma, Bronchial tumors, Bronchiolitis, Bronchiolitis obliterans, Bronchiolitis obliterans organizing pneumonia, Bronchitis, Bronchogenic carcinoma, Cheese worker's lung, Chemical worker's lung, Chest trauma, Chronic bronchitis, Chronic obstructive pulmonary disease (COPD), Chylothorax, CMV Pneumonitis, Community-acquired pneumonia, Cor Pulmonale, Cystic fibrosis, Decreased thoracic or diaphragmatic excursion, Diffuse panbronchiolitis, Pleural empyema, Eosinophilic pneumonia, Exercise-induced asthma, Extrinsic allergic alveolitis, Fat embolism, Fibrosing alveolitis, cryptogenic, Goodpasture syndrome, Grain handler's lung, Hemochlyothorax, Hemothorax, Histiocytosis X, Humidifier lung, Hydrochlyothorax, Hypersensitivity pneumonitis, Hypoxia, Idiopathic pulmonary fibrosis, Interstitial lung disease, Laryngeal/bronchospasm, Lung cancer, Lymphocytic interstitial pneumonia, Malt worker's lung, Miliary tuberculosis, Pleural callosity, Pneumoconiosis, Pneumochlyothorax, Pneumonia, Pneumothorax, Pleural effusion, Pleural fibrosis, Pulmonary arteriovenous malformation, Pulmonary edema, Pulmonary embolism, Pulmonary emphysema, Pulmonary fibrosis, Pulmonary hypertension, Shock lung, Tracheal stenosis, Tracheal tumors, Tracheomalacia, Tracheobronchial collapse
Renal / Electrolyte	Goodpasture syndrome, Metabolic acidosis, Uremia
Rheum / Immune / Allergy	Allergy, Anaphylactoid reactions, Anaphylaxis, Asthma, Bronchial asthma, Hypersensitivity pneumonitis, Lymphocytic interstitial pneumonia, Mollusk shell hypersensitivity, Mucor stolonifer, Quincke's edema
Sexual	No underlying causes
Trauma	Rib fractures, Chest trauma, Trauma
Urologic	No underlying causes
Miscellaneous	Air pollution, Altitude sickness, Chronic fatigue syndrome, Decompression sickness, Epidemic dropsy, Gamma-Hydroxybutyric acid, Obesity, Sarcoidosis

Causes in Alphabetical Order

Abdominal masses Acetylcysteine Acute bronchitis Acute chest syndrome Acute coronary syndromes Acute myeloid leukemia Acute promyelocytic leukemia Acute tracheobronchitis AIDS Air pollution Air-conditioner lung Allergy Alpha 1-antitrypsin deficiency Altitude sickness Amniotic fluid embolism Amphotericin B Amyl nitrite Amyotrophic lateral sclerosis (ALS) Anaphylactoid reactions Anaphylaxis Anemia Angina Pectoris Anthrax Anxiety Aortic arch anomalies Aortic regurgitation Aortic stenosis Arrhythmia Asbestosis Aspergillus clavatus Aspiration Asthma Atelectasis Atrial fibrillation Atrioseptal defect Atypical pneumonia Aztreonam Barium Beriberi heart disease Beta-blockers Betazole Bird breeder's lung Bird fancier's lung Biventricular heart failure Bland-White-Garland Syndrome Bleomycin in ABVD Blood transfusion Brain stem infarction Bronchial asthma Bronchial tumors Bronchiolitis Bronchiolitis obliterans Bronchiolitis obliterans organizing pneumonia Bronchitis Bronchogenic carcinoma Bronchoscopy Butorphanol Cardiac disease in pregnancy Cardiac failure Cardiomegaly Cardiomyopathy Caspofungin Cheese worker's lung Chemical worker's lung Chest trauma Chest tube Cholesterol pericarditis Chronic bronchitis Chronic fatigue syndrome Chronic obstructive pulmonary disease (COPD) Chylothorax Cirrhosis

Cladosporium CMV Pneumonitis Community-acquired pneumonia Congenital heart disease Congestive heart failure Continuous murmur Cor Pulmonae Coronary artery disease Coronary artery fistula Croup Cystic fibrosis Daptomycin Decompression sickness Desmopressin Decreased thoracic or diaphragmatic excursion Diabetic coma Diffuse panbronchiolitis Diverticulosis Drugs Ebstein's anomaly of the tricuspid valve Efavirenz Ehrlichiosis (canine) Empty nose syndrome Empyema, pleural Encephalitis Endocarditis Endomyocardial fibrosis Eosinophilic pneumonia Ephedrine Epidemic dropsy Erdheim-Chester disease Esophageal cancer Esophageal diseases with tracheal compression Exercise-induced asthma Extrinsic allergic alveolitis Fat embolism Fibrosing alveolitis, cryptogenic Gamma-Hydroxybutyric acid Gastroesophageal reflux Gemeprost Glatiramer acetate Glottal edema Goiter Goodpasture syndrome Grain handler's lung Gram-negative sepsis Guillain-Barre Syndrome Heart failure Hemochlyothorax Hemothorax Histiocytosis X Hoose (disease) Humidifier lung Hydrochlyothorax Hydroxocobalamin Hypersensitivity pneumonitis Hypertension Hypertensive heart disease Hyperthyroidism Hypertrophic cardiomyopathy Hypoxia Hysteria Idiopathic pulmonary fibrosis Iloprost Inappropriate sinus tachycardia Infliximab Interstitial lung disease Intoxication (carbon monoxide, cyanide) Intrapulmonary receptor stimulation Intussusception (medical disorder) Iron deficiency anemia Irregular heart rhythms Ketorolac

Kyphoscoliosis Laryngeal/bronchospasm Leukemia Levo-Transposition of the great arteries Loeffler's Endocarditis Lung cancer Lymphangitic metastases Lymphocytic interstitial pneumonia Lymphoma Malignant hypertension Malignant mesothelioma Malt worker's lung Mediastinal tumors Megaloblastic anemias Mercury (element) Metabolic acidosis Methyl isocyanate Micropolyspora faeni Mifepristone Miliary tuberculosis Mitral regurgitation Mitral stenosis Mollusk shell hypersensitivity Mucor stolonifer Multiple rib fractures Myasthenia gravis Myocardial infarction Myxoma Neuromuscular disease Niacin Obesity Panitumumab Patent ductus arteriosus Pericardial effusion/pericardial constriction Perimyocarditis Phrenic nerve paralysis Pleural callosity Pneumoconiosis Pneumonia Pneumochlyothorax Pneumothorax Pleural effusion Pleural fibrosis Polyradiculitis Pulmonary arteriovenous malformation Pulmonary edema Pulmonary embolism Pulmonary emphysema Pulmonary fibrosis Pulmonary hypertension Pulmonary stenosis Quincke's edema Radiation pneumonitis Respiratory tract infection Right ventricular failure Sarcoidosis Shock Shock lung Sleep apnea syndrome Sipuleucel-T Sorafenib STEMI Sunitinib Tenofovir disoproxil fumarate Tetralogy of Fallot Trauma Tracheal stenosis Tracheal tumors Tracheomalacia Tracheobronchial collapse Tretinoin Tricuspid stenosis Tumors of the myocardium Uremia Valvular heart disease Ventricular septal defect

Causes Based on Pathophysiology

Obstructive Lung Diseases

• Asthma
• Bronchitis
• Chronic obstructive pulmonary disease
• Cystic fibrosis
• Emphysema
• Hookworm disease
• Laryngeal edema due to allergies
• Tuberculosis

Diseases of Lung Parenchyma and Pleura

Contagious

• Anthrax through inhalation of Bacillus anthracis
• Pneumonia

Non-Contagious

• Fibrosing alveolitis
• Atelectasis
• Hypersensitivity pneumonitis
• Interstitial lung disease
• Lung cancer
• Pleural effusion
• Pneumoconiosis
• Pneumothorax
• Non-cardiogenic pulmonary edema or acute respiratory distress syndrome
• Sarcoidosis

Pulmonary Vascular Diseases

• Acute or recurrent pulmonary emboli
• Pulmonary hypertension, primary or secondary
• Pulmonary veno-occlusive disease
• Superior vena cava syndrome

Obstruction of the Airway

• Cancer of the larynx or pharynx
• Empty nose syndrome
• Pulmonary aspiration
• Epiglottitis

Immobilization of the Diaphragm

• Lesion of the phrenic nerve
• Polycystic liver disease
• Tumor in the diaphragm

Restriction of the Chest Volume

• Ankylosing spondylitis
• Broken ribs
• Kyphosis
• Obesity
• Pregnancy
• Pectus excavatum
• Scoliosis