Hepatic failure

Hepatic failure
ICD-10	K72.9
DiseasesDB	5728
MeSH	D017093

WikiDoc Resources for Hepatic failure
Articles
Most recent articles on Hepatic failure Most cited articles on Hepatic failure Review articles on Hepatic failure Articles on Hepatic failure in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Hepatic failure Images of Hepatic failure Photos of Hepatic failure Podcasts & MP3s on Hepatic failure Videos on Hepatic failure
Evidence Based Medicine
Cochrane Collaboration on Hepatic failure Bandolier on Hepatic failure TRIP on Hepatic failure
Clinical Trials
Ongoing Trials on Hepatic failure at Clinical Trials.gov Trial results on Hepatic failure Clinical Trials on Hepatic failure at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Hepatic failure NICE Guidance on Hepatic failure NHS PRODIGY Guidance FDA on Hepatic failure CDC on Hepatic failure
Books
Books on Hepatic failure
News
Hepatic failure in the news Be alerted to news on Hepatic failure News trends on Hepatic failure
Commentary
Blogs on Hepatic failure
Definitions
Definitions of Hepatic failure
Patient Resources / Community
Patient resources on Hepatic failure Discussion groups on Hepatic failure Patient Handouts on Hepatic failure Directions to Hospitals Treating Hepatic failure Risk calculators and risk factors for Hepatic failure
Healthcare Provider Resources
Symptoms of Hepatic failure Causes & Risk Factors for Hepatic failure Diagnostic studies for Hepatic failure Treatment of Hepatic failure
Continuing Medical Education (CME)
CME Programs on Hepatic failure
International
Hepatic failure en Espanol Hepatic failure en Francais
Business
Hepatic failure in the Marketplace Patents on Hepatic failure
Experimental / Informatics
List of terms related to Hepatic failure

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Liver failure; fulminating hepatic failure

Overview

Liver failure is the inability of the liver to perform its normal synthetic and metabolic function as part of normal physiology.

Classification

Two forms are recognised:

• Acute liver failure - development of hepatic encephalopathy (confusion, stupor and coma) and decreased production of proteins (such as albumin and blood clotting proteins) within four weeks of the first symptoms (such as jaundice) of a liver problem. "Hyperacute" liver failure is said to be present if this interval is 7 days or less, while "subacute" liver failure is said to be present if the interval is 5-12 weeks.
• Chronic liver failure usually occurs in the context of cirrhosis, itself potentially the result of many possible causes, such as excessive alcohol intake, hepatitis B or C, autoimmune, hereditary and metabolic causes (such as iron or copper overload or non-alcoholic fatty liver disease).

Causes

Drugs

• Carfilzomib
• Caspofungin acetate
• Cefadroxil
• Ceftazidime
• Chlordiazepoxide
• Dactinomycin
• Didanosine
• Diflunisal
• Efavirenz
• Fulvestrant
• Gemcitabine
• Indinavir
• Interferon gamma
• Ixabepilone
• Meropenem
• Micafungin sodium
• Oxaprozin
• Oxazepam
• Sorafenib
• Sulfasalazine
• Trovafloxacin mesylate
• Zafirlukast

Prognosis

The King's College criteria (KCC) may be used.

Contraindicated medications

Severe hepatic failure is considered an absolute contraindication to the use of the following medications:

• Carvedilol
• Conjugated estrogens/bazedoxifene
• Diclofenamide
• Dronedarone
• Nebivolol
• Rosuvastatin
• Simvastatin
• Spironolactone
• Hydrochlorothiazide

The ALFSG index is a newer option that may be more accurate.

See Also

• Hepato-biliary diseases
• Hepatitis

Template:WikiDoc Sources