List of chemotherapeutic agents: Difference between revisions
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{{SI}} | {{SI}} | ||
{{Seealso|Chemotherapy regimens}} | {{Seealso|Chemotherapy regimens}} | ||
{{CMG}}; {{AE}} {{AV}} {{AP}} | {{CMG}}; {{AE}} {{AV}}; {{AP}} | ||
==Overview== | ==Overview== | ||
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Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles. | Besides chemotherapy, medical oncology ([[pharmacotherapy]] for cancer) includes several noncytotoxic classes of therapy, such as [[hormonal therapy (oncology)|hormonal therapy]] and [[targeted therapy]] (biologic therapy). Those agents are described in the relevant articles. | ||
==Chemotherapeutic Agents by Category== | == Chemotherapeutic Agents by Category == | ||
{{button|Cytotoxic Chemotherapy}} | |||
===== Alkylating agents ===== | ===== Alkylating agents ===== | ||
*[[Estramustine]] | *[[Estramustine|Estramustine (Emcyt)]] | ||
*[[Procarbazine|Procarbazine(Matulane)]] | *[[Procarbazine|Procarbazine(Matulane)]] | ||
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===== Antimetabolites ===== | ===== Antimetabolites ===== | ||
*[[Fluorouracil |Fluorouracil (Adrucil, Efudex)]] | *[[Fluorouracil|Fluorouracil (Adrucil, Efudex)]] | ||
===== Antimitotic agent===== | ===== Antimitotic agent===== | ||
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===== Nitrogen mustards ===== | ===== Nitrogen mustards ===== | ||
===== Nitrosureas ===== | ===== Nitrosureas ===== | ||
===== Platinum agents ===== | ===== Platinum agents ===== | ||
===== Proteasome inhibitors ===== | ===== Proteasome inhibitors ===== | ||
===== Taxanes ===== | ===== Taxanes ===== | ||
===== Topoisomerase inhibitors ===== | ===== Topoisomerase inhibitors ===== | ||
*[[Irinotecan hydrochloride|Irinotecan (Camptosar)]] | *[[Irinotecan hydrochloride|Irinotecan (Camptosar)]] | ||
===== Vinca alkaloids ===== | ===== Vinca alkaloids ===== | ||
---- | ---- | ||
{{Button|Kinase Inhibitors}} | |||
*[[Idelalisib|Idelalisib (Zydelig)]] | *[[Idelalisib|Idelalisib (Zydelig)]] | ||
*[[Palbociclib|Palbociclib (Ibrance)]] | *[[Palbociclib|Palbociclib (Ibrance)]] | ||
---- | ---- | ||
{{Button|HDAC inhibitors}} | |||
---- | |||
{{Button|Endocrine therapy}} | |||
===== Antiandrogens ===== | ===== Antiandrogens ===== | ||
===== Steroid synthesis inhibitors ===== | ===== Steroid synthesis inhibitors ===== | ||
===== Androgen receptor inhibitors ===== | ===== Androgen receptor inhibitors ===== | ||
*[[Nilutamide|Nilutamide (Nilandron)]] | *[[Nilutamide|Nilutamide (Nilandron)]] | ||
===== 5α-reductase inhibitors ===== | ===== 5α-reductase inhibitors ===== | ||
===== GnRH agonists ===== | ===== GnRH agonists ===== | ||
* [[Buserelin|Buserelin (Superfact)]] | * [[Buserelin|Buserelin (Superfact)]] | ||
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===== Aromatase inhibitors ===== | ===== Aromatase inhibitors ===== | ||
===== Selective estrogen receptor modulators ===== | ===== Selective estrogen receptor modulators ===== | ||
---- | ---- | ||
{{Button|Biologics}} | |||
===== Antibody medications ===== | ===== Antibody medications ===== | ||
*[[Ibritumomab tiuxetan]] | *[[Ibritumomab tiuxetan]] | ||
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===== Antibody-drug conjugates ===== | ===== Antibody-drug conjugates ===== | ||
===== Anti-HER2 medications ===== | ===== Anti-HER2 medications ===== | ||
===== IL-6 inhibitors ===== | ===== IL-6 inhibitors ===== | ||
*[[Siltuximab|Siltuximab (Sylvant)]] | *[[Siltuximab|Siltuximab (Sylvant)]] | ||
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===== Immunotherapy ===== | ===== Immunotherapy ===== | ||
===== Immunomodulatory drugs (IMiDs) ===== | ===== Immunomodulatory drugs (IMiDs) ===== | ||
* [[Lenalidomide|Lenalidomide (Revlimid)]] | * [[Lenalidomide|Lenalidomide (Revlimid)]] | ||
* [[Pomalidomide|Pomalidomide (Pomalyst)]] | * [[Pomalidomide|Pomalidomide (Pomalyst)]] | ||
---- | ---- | ||
{{Button|Hematopoietic Growth Factors}} | |||
===== Erythrocyte growth factors ===== | ===== Erythrocyte growth factors ===== | ||
===== Granulocyte growth factors ===== | ===== Granulocyte growth factors ===== | ||
*[[Filgrastim|Filgrastim (Granix)]] | *[[Filgrastim|Filgrastim (Granix)]] | ||
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===== Megakaryocyte growth factors ===== | ===== Megakaryocyte growth factors ===== | ||
---- | ---- | ||
{{Button|Supportive Medications}} | |||
===== Chemotherapy protective agents ===== | ===== Chemotherapy protective agents ===== | ||
*[[Amifostine|Amifostine (Ethyol)]] | *[[Amifostine|Amifostine (Ethyol)]] | ||
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*[[Levoleucovorin|Levoleucovorin (Fusilev)]] | *[[Levoleucovorin|Levoleucovorin (Fusilev)]] | ||
*[[Mesna|Mesna (Mesnex)]] | *[[Mesna|Mesna (Mesnex)]] | ||
===== Antiemetic agents ===== | ===== Antiemetic agents ===== | ||
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===== RANK ligand inhibitors ===== | ===== RANK ligand inhibitors ===== | ||
---- | ---- | ||
{{Button|Miscellaneous}} | |||
*[[Pegaspargase|Pegaspargase (Oncaspar)]] | *[[Pegaspargase|Pegaspargase (Oncaspar)]] | ||
*[[Ramucirumab|Ramucirumab (Cyramza)]] | *[[Ramucirumab|Ramucirumab (Cyramza)]] | ||
---- | ---- | ||
Revision as of 18:35, 18 February 2015
Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]; Alberto Plate [3]
Overview
This is a list of chemotherapeutic agents (also known as cytotoxic agents) that are known to be of use in chemotherapy for cancer. This list is organized by type of agent, although the subsections are not necessarily definitive and are subject to revision. Each drug is listed once (at present), though it might fall in more than one subsection. A full alphabetical listing is included after the categorical listing.
The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy). For example, the CHOP regimen consists of cyclophosphamide, hydroxydaunorubicin (doxorubicin), vincristine (Oncovin), and prednisone.
Besides chemotherapy, medical oncology (pharmacotherapy for cancer) includes several noncytotoxic classes of therapy, such as hormonal therapy and targeted therapy (biologic therapy). Those agents are described in the relevant articles.
Chemotherapeutic Agents by Category
Cytotoxic Chemotherapy
Alkylating agents
Anthracyclines
Antimetabolites
Antimitotic agent
DNA synthesis inhibitors
Microtubule inhibitors
Nitrogen mustards
Nitrosureas
Platinum agents
Proteasome inhibitors
Taxanes
Topoisomerase inhibitors
Vinca alkaloids
Kinase Inhibitors
HDAC inhibitors
Endocrine therapy
Antiandrogens
Steroid synthesis inhibitors
Androgen receptor inhibitors
5α-reductase inhibitors
GnRH agonists
GnRH antagonists
Aromatase inhibitors
Selective estrogen receptor modulators
Biologics
Antibody medications
Antibody-drug conjugates
Anti-HER2 medications
IL-6 inhibitors
IL-2 inhibitors
Enzyme Inhibitors
Immunotherapy
Immunomodulatory drugs (IMiDs)
Hematopoietic Growth Factors
Erythrocyte growth factors
Granulocyte growth factors
Megakaryocyte growth factors
Supportive Medications
Chemotherapy protective agents
- Amifostine (Ethyol)
- Cyanocobalamin
- Dexrazoxane (Zinecard)
- Folinic acid (Leucovorin)
- Glucarpidase (Voraxaze)
- Levoleucovorin (Fusilev)
- Mesna (Mesnex)
Antiemetic agents
RANK ligand inhibitors
Miscellaneous
Chemotherapeutic Agents in Alphabetical Order
- Abiraterone acetate (Zytiga)
- Ado-trastuzumab emtansine (Kadcyla)
- Afatinib (Gliotrif)
- Aldesleukin (Proleukin)
- Altretamine (Hexalen)
- Amifostine (Ethyol)
- Anastrozole (Arimidex)
- Arsenic trioxide (Trisenox)
- Asparaginase Erwinia chrysanthemi (Erwinaze)
- Axitinib (Inlyta)
- Azacytidine (Vidaza)
- Belinostat (Beleodaq)
- Bendamustine (Treanda)
- Bevacizumab (Avastin)
- Bexarotene (Targretin)
- Bicalutamide (Casodex)
- Bleomycin (Blenoxane)
- Blinatumomab (Blincyto)
- Bosutinib (Bosulif)
- Brentuximab vedotin (Adcetris)
- Buserelin (Suprefact)
- Busulfan (Myleran-oral)
- Cabazitaxel (Jevtana)
- Cabozantinib (Cometriq)
- Capecitabine (Xeloda)
- Carboplatin (Paraplatin)
- Carfilzomib (Kyprolis)
- Carmustine (BiCNU)
- Ceritinib (Zykadia)
- Cetuximab (Erbitux)
- Chlorambucil (Leukeran)
- Cisplatin (Platinol)
- Crizotinib (Xalkori)
- Dabrafenib (Tafinlar)
- Dasatinib (Sprycel)
- Daunorubicin (Daunoxome)
- Decitabine (Dacogen)
- Degarelix (Firmagon)
- Denileukin diftitox (Ontak)
- Denosumab (Xgeva)
- Dexamethasone (Decadron)
- Dexrazoxane (Zinecard)
- Docetaxel (Taxotere)
- Doxorubicin (Adriamycin, Rubex)
- Enzalutamide (Xtandi)
- Epirubicin (Ellence)
- Eribulin (Halaven)
- Erlotinib (Tarceva)
- Erythropoietin (Epogen, Procrit)
- Estramustine (Emcyt)
- Etoposide (Vespid)
- Everolimus (Afinitor)
- Exemestane (Aromasin)
- Filgrastim (Neupogen)
- Floxuridine (FUDR)
- Fludarabine (Fludara)
- Fluorouracil (Adrucil, Efudex)
- Fluoxymesterone (Halotestin)
- Flutamide (Eulexin)
- Folinic acid (Leucovorin Calcium)
- Fulvestrant (Faslodex)
- Gallium Nitrate (Ganite)
- Gemcitabine (Gemzar)
- Gemtuzumab ozogamicin (Mylotarg)
- Glucarpidase (Voraxaze)
- Goserelin Acetate (Zoladex)
- Hydroxyurea (Hydrea)
- Ibritumomab tiuxetan (Zevalin)
- Ibrutinib (Imbruvica)
- Idarubicin (Idamycin)
- Idelalisib (Zydelig)
- Ifosfamide (Ifex)
- interferon alfa-2b (Intron A)
- Ipilimumab (Yervoy)
- Irinotecan (Camptosar)
- Isotretinoin (Accutane)
- Ixabepilone (Ixempra)
- L-Asparaginase (Elspar)
- Lapatinib (Tykerb)
- Lenalidomide (Revlimid)
- Lenvatinib (Lenvima)
- Letrozole (Femara)
- Leuprolide (Lupron)
- Levoleucovorin (Fusilev)
- Lomustine (CeeNU)
- Mechlorethamine (Mustargen)
- Medroxyprogesterone acetate (Provera)
- Megestrol (Megace)
- Melphalan (Alkeran)
- Mercaptopurine (Purinethol)
- Mesna (Mesnex)
- Methotrexate (Mexate, Folex)
- Mitomycin C (Mutamycin)
- Mitotane (Lysodren)
- Mitoxantrone (Novantrone)
- Nelarabine (Arranon)
- Netupitant and palonosetron (Akynzeo)
- Nilotinib (Tasigna)
- Nilutamide (Nilandron)
- Nivolumab (Opdivo)
- Obinutuzumab (Gazyva)
- Octreotide (Octreotide)
- Ofatumumab (Arzerra)
- Olaparib (Lynparza)
- Omacetaxine (Synribo)
- Oprelvekin (Neumega)
- Oxaliplatin (Eloxatin)
- Paclitaxel (Taxol, Onxol)
- Palbociclib (Ibrance)
- Pamidronate (Aredia)
- Panitumumab (Vectibix)
- Pazopanib (Votrient)
- PEG-Asparaginase (Oncaspar)
- Pegfilgrastim (Neulasta)
- Peginterferon alfa-2b (Sylatron)
- Pembrolizumab (Keytruda)
- Pemetrexed (Alimta)
- Pentostatin (Nipent)
- Pertuzumab (Perjeta)
- Plerixafor (Mozobil)
- Pomalidomide (Pomalyst)
- Ponatinib (Iclusig)
- Pralatrexate (Folotyn)
- Prednisone (Deltasone)
- Procarbazine (Matulane)
- Radium-223 chloride (Xofigo)
- Ramucirumab (Cyramza)
- Rasburicase (Elitek)
- Regorafenib (Stivarga)
- Rituximab (Rituxan)
- Romidepsin (Istodax)
- Ruxolitinib (Jakafi)
- Sargramostim (Leukine, Leukomax)
- Siltuximab (Sylvant)
- Sipuleucel-T (Provenge)
- Sorafenib (Nexavar)
- Streptozocin (Zanosar)
- Sunitinib (Sutent)
- Tamoxifen (Nolvadex)
- Tbo-filgrastim (Granix)
- Temozolomide (Temodar)
- Temsirolimus (Torisel)
- Teniposide (Vumon)
- Thalidomide (Thalomid)
- Thioguanine (Tabloid)
- Thiotepa (TESPA)
- Tocilizumab (Actemra)
- Topotecan (Hycamtin)
- Toremifene (Fareston)
- Trametinib (Mekinist)
- Trastuzumab (Herceptin)
- Tretinoin (Vesanoid)
- Vandetanib (Caprelsa)
- Vemurafenib (Zelboraf)
- Vinblastine (Velban, Velsar)
- Vincristine (Oncovin, Vincasar)
- Vincristine liposomal (Marqibo)
- Vinorelbine (Navelbine)
- Vismodegib (Erivedge)
- Ziv-aflibercept (Zaltrap)
- Zoledronic Acid (Zometa)