List of chemotherapeutic agents: Difference between revisions

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Revision as of 22:24, 23 February 2015

Template:Seealso Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aparna Vuppala, M.B.B.S. [2]

Overview

This is a list of chemotherapeutic agents that are known to be of use in chemotherapy for cancer. A full alphabetical listing is included after the categorical listing.

The agents in this list are often combined into chemotherapy regimens for polychemotherapy (combination chemotherapy).

Chemotherapeutic Agents by Category

Alkylating agents

Nitrogen mustards

Nitrosoureas

Triazenes

Platinum coordination complexes

Antimetabolites

Folic acid analogs

Pyrimidine analogs

Purine analogs

Ribonucleotide reductase inhibitors

Hydroxyurea (Hydrea)

Natural products

Vinca alkaloids

Taxanes

Epipodophyllotoxins

Camptothecins

Antineoplastic antibiotics

Antineoplastic enzymes

Hormones and Antagonists

Adrenocortical suppressants

Mitotane (Lysodren)

Adrenocortico-steroids

Prednisone (Deltasone)

Progestins

Anti-estrogens

Aromatase inhibitors

Androgens

Fluoxymesterone (Halotestin)

Anti-androgens

GnRH agonists

GnRH antagonists

Degarelix (Firmagon)

Biologics

Monoclonal antibodies

Anti-CD20 antibodies

Anti-CD30 antibodies

Brentuximab (Adcetris)

Anti-CD33 antibodies

Gemtuzumab (Mylotarg)

Anti-CD52 antibodies

Alemtuzumab (Campath)

Anti-CTLA–4 antibodies

Ipilimumab (Yervoy)

Anti-EGFR (ErbB1) antibodies

Anti-PD–1 antibodies

Anti-HER2/neu (ErbB2) antibodies

Anti-VEGF antibodies

Bevacizumab (Avastin)

IL-2 inhibitors

IL-6 inhibitors

Siltuximab (Sylvant)

Immunotherapy

Interferon alfa-2b (Intron A)

Hematopoietic Growth Factors

Erythrocyte growth factors

Erythropoietin (Procrit)

Granulocyte growth factors

Megakaryocyte growth factors

Eltrombopag (Promacta)

Supportive Medications

Chemotherapy protective agents

Antiemetic agents

Netupitant and palonosetron (Akynzeo)

RANK ligand inhibitors

Denosumab (Xgeva)

Miscellaneous

Mitotic inhibitors

Bisphosphonates

Zoledronic Acid (Zometa)

HDAC inhibitors

Hedgehog pathway inhibitors

Vismodegib (Erivedge)

Immunomodulatory drugs (IMiDs)

Kinase inhibitors

mTOR Inhibitors

Proteasome inhibitors

Radioactive agents

Radium-223 chloride (Xofigo)

Somatostatin analogs

Octreotide (Octreotide)

VEGF receptor-2 antagonists

Ramucirumab (Cyramza)

Chemotherapeutic Agents in Alphabetical Order

@@ Line 2: / Line 2: @@
 {{SI}}
 {{Seealso|Chemotherapy regimens}}
-{{CMG}}; {{AE}} {{AV}}; {{AP}}
+{{CMG}}; {{AE}} {{AV}}
 ==Overview==
@@ Line 11: / Line 11: @@
 == Chemotherapeutic Agents by Category ==
-{{button|Cytotoxic Chemotherapy}}
+=== Alkylating agents ===
-==== Alkylating agents ====
+====== Nitrogen mustards ======
-* [[Altretamine|Altretamine (Hexalen)]]
-* [[Bendamustine|Bendamustine (Treanda)]]
-* [[Busulfan|Busulfan (Myleran)]]
-* [[Carmustine|Carmustine (BiCNU)]]
 * [[Chlorambucil|Chlorambucil (Leukeran)]]
 * [[Cyclophosphamide|Cyclophosphamide (Cytoxan)]]
-* [[Estramustine|Estramustine (Emcyt)]]
 * [[Ifosfamide|Ifosfamide (Iflex)]]
-* [[Lomustine|Lomustine (CeeNU)]]
+* [[Melphalan|Melphalan (Alkeran)]]
 * [[Mechlorethamine|Mechlorethamine (Mustargen)]]
-* [[Melphalan|Melphalan (Alkeran)]]
+====== Ethylenimines ======
+* [[Thiotepa|Thiotepa (Tepadina)]]
+====== Methylhydrazines ======
 * [[Procarbazine|Procarbazine (Matulane)]]
-* [[Thiotepa|Thiotepa (Tepadina)]]
-===== Anthracyclines =====
+====== Alkylsulfonates ======
-*[[Daunorubicin|Daunorubicin (Daunoxome)]]
+* [[Busulfan|Busulfan (Myleran)]]
-*[[Doxorubicin|Doxorubicin (Adriamycin,Rubex)]]
-*[[Epirubicin|Epirubicin (Ellence)]]
+====== Nitrosoureas ======
-*[[Idarubicin hydrochloride|Idarubicin (Idamycin)]]
+* [[Bendamustine|Bendamustine (Treanda)]]
+* [[Carmustine|Carmustine (BiCNU)]]
+* [[Lomustine|Lomustine (CeeNU)]]
+* [[Streptozocin|Streptozocin (Zanosar)]]
+====== Triazenes ======
+* [[Altretamine|Altretamine (Hexalen)]]
+* [[Dacarbazine|Dacarbazine (Dtic-Dome)]]
+* [[Temozolomide|Temozolomide (Temodar)]]
+====== Platinum coordination complexes ======
+* [[Carboplatin|Carboplatin (Paraplatin)]]
+* [[Cisplatin|Cisplatin (Platinol)]]
+* [[Oxaliplatin|Oxaliplatin (Eloxatin)]]
+----
-===== Antimetabolites =====
+=== Antimetabolites ===
-*[[Capecitabine|Capecitabine (Xeloda)]]
-*[[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
-*[[Floxuridine|Floxuridine (FUDR)]]
-*[[Fludarabine|Fludarabine (Fludara)]]
-*[[Gemcitabine|Gemcitabine (Gemzar)]]
-*[[Hydroxyurea|Hydroxyurea (Hydrea)]]
-*[[Mercaptopurine|Mercaptopurine (Purinethol)]]
-*[[Methotrexate|Methotrexate (Mexate,Folex)]]
-===== Antimitotic agent=====
+====== Folic acid analogs ======
-*[[Docetaxel|Docetaxel (Taxotere)]]
+* [[Methotrexate|Methotrexate (Mexate, Folex)]]
-*[[Eribulin|Eribulin (Halaven)]]
+* [[Pemetrexed|Pemetrexed (Alimta)]]
-*[[Etoposide|Etoposide (Vespid)]]
-*[[Ixabepilone|Ixabepilone (Ixempra)]]
-*[[Vinblastine|Vinblastine (Velban,Velsar)]]
-*[[Vincristine|Vincristine (Oncovin,Vincasar)]]
-*[[Vinorelbine|Vinorelbine (Navelbine)]]
+====== Pyrimidine analogs ======
+* [[Azacytidine|Azacytidine (Vidaza)]]
+* [[Capecitabine|Capecitabine (Xeloda)]]
+* [[Cytarabine|Cytarabine (Cytosar)]]
+* [[Floxuridine|Floxuridine (FUDR)]]
+* [[Fluorouracil|Fluorouracil (Adrucil, Efudex)]]
+* [[Gemcitabine|Gemcitabine (Gemzar)]]
-===== DNA synthesis inhibitors =====
+====== Purine analogs ======
-*[[Streptozocin|Streptozocin (Zanosar)]]
+* [[Cladribine|Cladribine (Leustatin)]]
+* [[Clofarabine|Clofarabine (Clolar)]]
+* [[Fludarabine|Fludarabine (Fludara)]]
+* [[Mercaptopurine|Mercaptopurine (Purinethol)]]
+* [[Nelarabine|Nelarabine (Arranon)]]
+* [[Pentostatin|Pentostatin (Nipent)]]
+* [[Thioguanine|Thioguanine (Tabloid)]]
-===== Microtubule inhibitors =====
+====== Ribonucleotide reductase inhibitors ======
-*[[Ixabepilone|Ixabepilone (Ixempra)]]
+* [[Hydroxyurea|Hydroxyurea (Hydrea)]]
-===== Nitrogen mustards =====
+----
-*[[Estramustine|Estramustine (Emcyt)]]
-*[[Mechlorethamine|Mechlorethamine (Mustargen)]]
-===== Nitrosureas =====
+=== Natural products ===
-*[[Lomustine|Lomustine (CeeNU)]]
-===== Platinum agents =====
+====== Vinca alkaloids ======
+* [[Vinblastine|Vinblastine (Velban, Velsar)]]
+* [[Vincristine|Vincristine (Oncovin, Vincasar)]]
+* [[Vincristine liposome|Vincristine liposome (Marqibo)]]
+* [[Vinorelbine|Vinorelbine (Navelbine)]]
-===== Proteasome inhibitors =====
+====== Taxanes ======
-*[[Carfilzomib|Carfilzomib (Kyprolis)]]
+* [[Docetaxel|Docetaxel (Taxotere)]]
+* [[Paclitaxel|Paclitaxel (Taxol, Onxol)]]
-===== Taxanes =====
+====== Epipodophyllotoxins ======
+* [[Etoposide|Etoposide (Vespid)]]
+* [[Teniposide|Teniposide (Vumon)]]
-===== Topoisomerase inhibitors =====
+====== Camptothecins ======
-*[[Irinotecan hydrochloride|Irinotecan (Camptosar)]]
+* [[Irinotecan|Irinotecan (Camptosar)]]
+* [[Topotecan|Topotecan (Hycamtin)]]
-===== Vinca alkaloids =====
+====== Antineoplastic antibiotics ======
-*[[Vinblastine|Vinblastine (Velban,Velsar)]]
+* [[Bleomycin|Bleomycin (Blenoxane)]]
-*[[Vincristine|Vincristine (Oncovin,Vincasar)]]
+* [[Dactinomycin|Dactinomycin (Cosmegen)]]
+* [[Daunorubicin|Daunorubicin (Daunoxome)]]
+* [[Doxorubicin|Doxorubicin (Adriamycin, Rubex)]]
+* [[Epirubicin|Epirubicin (Ellence)]]
+* [[Idarubicin|Idarubicin (Idamycin)]]
+* [[Mitomycin C|Mitomycin C (Mutamycin)]]
+* [[Mitoxantrone|Mitoxantrone (Novantrone)]]
+* [[Valrubicin|Valrubicin (Valstar)]]
+====== Antineoplastic enzymes ======
+* [[L-Asparaginase|L-Asparaginase (Elspar)]]
+* [[Pegaspargase|Pegaspargase (Oncaspar)]]
+* [[Glucarpidase|Glucarpidase (Voraxaze)]]
 ----
-{{Button|Endocrine therapy}}
+=== Hormones and Antagonists ===
+====== Adrenocortical suppressants ======
+* [[Mitotane|Mitotane (Lysodren)]]
+====== Adrenocortico-steroids ======
+* [[Prednisone|Prednisone (Deltasone)]]
+====== Progestins ======
+* [[Medroxyprogesterone|Medroxyprogesterone (Provera)]]
+* [[Megestrol|Megestrol (Megace)]]
+====== Anti-estrogens ======
+* [[Tamoxifen|Tamoxifen (Nolvadex)]]
+* [[Toremifene|Toremifene (Fareston)]]
-===== Antiandrogens =====
+====== Aromatase inhibitors ======
+* [[Anastrozole|Anastrozole (Arimidex)]]
+* [[Exemestane|Exemestane (Aromasin)]]
+* [[Letrozole|Letrozole (Femara)]]
+====== Androgens ======
+* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
+====== Anti-androgens ======
 * [[Abiraterone|Abiraterone (Zytiga)]]
 * [[Bicalutamide|Bicalutamide (Casodex)]]
 * [[Dutasteride|Dutasteride (Avodart)]]
 * [[Enzalutamide|Enzalutamide (Xtandi)]]
+* [[Flutamide|Flutamide (Eulexin)]]
 * [[Finasteride|Finasteride (Proscar)]]
-* [[Flutamide|Flutamide (Eulexin)]]
 * [[Ketoconazole|Ketoconazole (Nizoral)]]
-* [[Leuprolide|Leuprolide (Lupron)]]
 * [[Nilutamide|Nilutamide (Nilandron)]]
 * [[Triptorelin|Triptorelin (Trelstar)]]
-===== Steroid synthesis inhibitors =====
+===== GnRH agonists =====
-* [[Abiraterone|Abiraterone (Zytiga)]]
+* [[Buserelin|Buserelin (Superfact)]]
-* [[Aminoglutethimide|Aminoglutethimide (Cytadren)]]
+* [[Goserelin|Goserelin (Zoladex)]]
-* [[Anastrozole|Anastrozole (Arimidex)]]
+* [[Leuprolide|Leuprolide (Lupron)]]
-* [[Exemestane|Exemestane (Aromasin)]]
-* [[Letrozole|Letrozole (Femara)]]
-* [[Mitotane|Mitotane (Lysodren)]]
-===== Androgen receptor inhibitors =====
+===== GnRH antagonists =====
-*[[Nilutamide|Nilutamide (Nilandron)]]
+* [[Degarelix|Degarelix (Firmagon)]]
-===== 5α-reductase inhibitors =====
+----
-===== GnRH agonists =====
+=== Biologics ===
-* [[Buserelin|Buserelin (Superfact)]]
-* [[Goserelin Acetate|Goserelin Acetate (Zoladex)]]
-* [[Leuprolide|Leuprolide (Lupron)]]
-===== GnRH antagonists =====
+===== Monoclonal antibodies =====
-*[[Degarelix|Degarelix (Firmagon)]]
-===== Aromatase inhibitors =====
+====== Anti-CD20 antibodies ======
-*[[Anastrozole|Anastrozole (Arimidex)]]
+* [[Rituximab|Rituximab (Rituxan)]]
-*[[Exemestane|Exemestane (Aromasin))]]
+* [[Ibritumomab|Ibritumomab (Zevalin)]]
-*[[Letrozole|Letrozole (Femara)]]
+* [[Obinutuzumab|Obinutuzumab (Gazyva)]]
-===== Selective estrogen receptor modulators =====
+* [[Ofatumumab|Ofatumumab (Arzerra)]]
-----
+====== Anti-CD30 antibodies ======
+* [[Brentuximab|Brentuximab (Adcetris)]]
-{{Button|Biologics}}
+====== Anti-CD33 antibodies ======
+* [[Gemtuzumab|Gemtuzumab (Mylotarg)]]
-===== Antibody medications =====
+====== Anti-CD52 antibodies ======
-*[[Cetuximab|Cetuximab (Erbitux)]]
+* [[Alemtuzumab|Alemtuzumab (Campath)]]
-*[[Denosumab|Denosumab (Xgeva)]]
-*[[Ibritumomab tiuxetan|Ibritumomab tiuxetan (Zevalin)]]
-*[[Ipilimumab|Ipilimumab (Yervoy)]]
-*[[Nivolumab |Nivolumab (Opdivo)]]
-*[[Obinutuzumab|Obinutuzumab (Gazyva)]]
-*[[Ofatumumab|Ofatumumab (Arzerra)]]
-*[[Pembrolizumab|Pembrolizumab (KEYTRUDA)]]
+====== Anti-CTLA–4 antibodies ======
+* [[Ipilimumab|Ipilimumab (Yervoy)]]
-===== Antibody-drug conjugates =====
+====== Anti-EGFR (ErbB1) antibodies ======
-*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
+* [[Cetuximab|Cetuximab (Erbitux)]]
-*[[Brentuximab vedotin|Brentuximab vedotin (Adcetris)]]
+* [[Panitumumab|Panitumumab (Vectibix)]]
-*[[Gemtuzumab ozogamicin|Gemtuzumab ozogamicin (Mylotarg)]]
-===== Anti-HER2 medications =====
+====== Anti-PD–1 antibodies ======
-*[[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
+* [[Nivolumab |Nivolumab (Opdivo)]]
-*[[Trastuzumab|Trastuzumab (Herceptin)]]
+* [[Pembrolizumab|Pembrolizumab (Keytruda)]]
-===== Enzymes =====
+====== Anti-HER2/neu (ErbB2) antibodies ======
-*[[Pegaspargase|Pegaspargase (Oncaspar)]]
+* [[Ado-trastuzumab emtansine|Ado-trastuzumab emtansine (Kadcyla)]]
-*[[Glucarpidase|Glucarpidase (Voraxaze)]]
+* [[Trastuzumab|Trastuzumab (Herceptin)]]
-===== IL-6 inhibitors =====
+====== Anti-VEGF antibodies ======
-*[[Siltuximab|Siltuximab (Sylvant)]]
+* [[Bevacizumab|Bevacizumab (Avastin)]]
 ===== IL-2 inhibitors =====
+* [[Aldesleukin|Aldesleukin (Proleukin)]]
 * [[Denileukin diftitox|Denileukin diftitox (Ontak)]]
+===== IL-6 inhibitors =====
+* [[Siltuximab|Siltuximab (Sylvant)]]
 ===== Immunotherapy =====
-*[[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
+* [[Interferon alfa-2b|Interferon alfa-2b (Intron A)]]
-===== Immunomodulatory drugs (IMiDs) =====
-* [[Everolimus|Everolimus (Afinitor)]]
-* [[Lenalidomide|Lenalidomide (Revlimid)]]
-* [[Pomalidomide|Pomalidomide (Pomalyst)]]
 ----
-{{Button|Hematopoietic Growth Factors}}
+=== Hematopoietic Growth Factors ===
 ===== Erythrocyte growth factors =====
-*[[Erythropoietin|Erythropoietin (Procrit)]]
+* [[Erythropoietin|Erythropoietin (Procrit)]]
 ===== Granulocyte growth factors =====
-*[[Filgrastim|Filgrastim (Granix)]]
+* [[Filgrastim|Filgrastim (Granix)]]
-*[[Sargramostim|Sargramostin (Leukine)]]
+* [[Sargramostim|Sargramostin (Leukine)]]
-*[[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
+* [[Tbo-filgrastim|Tbo-filgrastim (Granix)]]
 ===== Megakaryocyte growth factors =====
 * [[Eltrombopag|Eltrombopag (Promacta)]]
-* [[Romiplostim|Romiplostim (Nplate)]]
 ----
-{{Button|Supportive Medications}}
+=== Supportive Medications ===
 ===== Chemotherapy protective agents =====
-*[[Amifostine|Amifostine (Ethyol)]]
+* [[Amifostine|Amifostine (Ethyol)]]
-*[[Cyanocobalamin|Cyanocobalamin]]
+* [[Cyanocobalamin|Cyanocobalamin]]
-*[[Dexrazoxane|Dexrazoxane (Zinecard)]]
+* [[Dexrazoxane|Dexrazoxane (Zinecard)]]
-*[[Folinic acid|Folinic acid (Leucovorin)]]
+* [[Folinic acid|Folinic acid (Leucovorin)]]
-*[[Glucarpidase|Glucarpidase (Voraxaze)]]
+* [[Glucarpidase|Glucarpidase (Voraxaze)]]
-*[[Levoleucovorin|Levoleucovorin (Fusilev)]]
+* [[Levoleucovorin|Levoleucovorin (Fusilev)]]
-*[[Mesna|Mesna (Mesnex)]]
+* [[Mesna|Mesna (Mesnex)]]
 ===== Antiemetic agents =====
-*[[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]
+* [[Netupitant and palonosetron |Netupitant and palonosetron (Akynzeo)]]
 ===== RANK ligand inhibitors =====
@@ Line 206: / Line 241: @@
 ----
-{{Button|Miscellaneous}}
+=== Miscellaneous ===
-===== Antibiotic =====
-*[[Mitomycin C|Mitomycin C (Mutamycin)]]
+===== Mitotic inhibitors =====
+* [[Eribulin|Eribulin (Halaven)]]
+* [[Ixabepilone|Ixabepilone (Ixempra)]]
-===== Bisphosphonate =====
+===== Bisphosphonates =====
 * [[Zoledronic Acid|Zoledronic Acid (Zometa)]]
-===== Endocrine-Metabolic agents =====
-* [[Fluoxymesterone|Fluoxymesterone (Halotestin)]]
-* [[Medroxyprogesterone acetate|Medroxyprogesterone acetate (Provera)]]
-* [[Megestrol|Megestrol (Megace)]]
 ===== HDAC inhibitors =====
@@ Line 226: / Line 257: @@
 ===== Hedgehog pathway inhibitors =====
 * [[Vismodegib|Vismodegib (Erivedge)]]
+===== Immunomodulatory drugs (IMiDs) =====
+* [[Everolimus|Everolimus (Afinitor)]]
+* [[Lenalidomide|Lenalidomide (Revlimid)]]
+* [[Pomalidomide|Pomalidomide (Pomalyst)]]
 ===== Kinase inhibitors =====
 * [[Afatinib|Afatinib (Gliotrif)]]
 * [[Cabozantinib|Cabozantinib (Cometriq)]]
@@ Line 234: / Line 269: @@
 * [[Dasatinib|Dasatinib (Sprycel)]]
 * [[Erlotinib|Erlotinib (Tarceva)]]
+* [[Gefitinib|Gefitinib (Iressa)]]
 * [[Ibrutinib|Ibrutinib (Imbruvica)]]
 * [[Idelalisib|Idelalisib (Zydelig)]]
@@ Line 239: / Line 275: @@
 * [[Nilotinib|Nilotinib (Tasigna)]]
 * [[Palbociclib|Palbociclib (Ibrance)]]
+* [[Sorafenib|Sorafenib (Nexavar)]]
+* [[Sunitinib|Sunitinib (Sutent)]]
+===== mTOR Inhibitors =====
+* [[Temsirolimus|Temsirolimus (Torisel)]]
+* [[Everolimus|Everolimus (Afinitor)]]
+===== Proteasome inhibitors =====
+* [[Bortezomib|Bortezomib (Velcade)]]
+* [[Carfilzomib|Carfilzomib (Kyprolis)]]
 ===== Radioactive agents =====
 * [[Radium-223 chloride|Radium-223 chloride (Xofigo)]]
-===== Somatostatin analogues =====
+===== Somatostatin analogs =====
 * [[Octreotide|Octreotide (Octreotide)]]