Hydroa vacciniforme-like lymphoma: Difference between revisions

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==Pathophysiology==
==Pathophysiology==
===Histopathology===
*Histopathologic examination showed lymphocytic infiltrate with:<ref name="pmid23541598">{{cite journal| author=Sangueza M, Plaza JA| title=Hydroa vacciniforme-like cutaneous T-cell lymphoma: clinicopathologic and immunohistochemical study of 12 cases. | journal=J Am Acad Dermatol | year= 2013 | volume= 69 | issue= 1 | pages= 112-9 | pmid=23541598 | doi=10.1016/j.jaad.2013.01.037 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23541598  }} </ref>
**[[Angiotropism]] 
**[[Angiocentricity]]
===Immunophenotype===
*[[CD8]] positive
*[[CD45RO]] or [[CD56]]<ref name="pmid20497358">{{cite journal| author=Xu Z, Lian S| title=Epstein-Barr virus-associated hydroa vacciniforme-like cutaneous lymphoma in seven Chinese children. | journal=Pediatr Dermatol | year= 2010 | volume= 27 | issue= 5 | pages= 463-9 | pmid=20497358 | doi=10.1111/j.1525-1470.2010.01094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20497358  }} </ref>


==Causes==
==Causes==

Revision as of 19:40, 24 February 2015

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Alberto Plate [2]

Synonyms and keywords: Hydroa-like CTCL, HVLL

Overview

Hydroa vacciniforme-like lymphoma is a EBV-positive peripheral T-cell lymphoma (Non-Hodgkin's lymphoma), that affects primarily pediatric patients and has a bad prognosis.[1] It is associated with photosensitivity and insect bites.[2] Clinically, it manifests with vacciniform vesicles, necrotic ulcers and scars.[3]

Historical Perspective

Hydroa vacciniforme-like lymphoma reports date back from 1986,[4] although only since 2008, the WHO recognizes the HVLL as a separate entity from the Hydroa vacciniforme and classified it under "EBV positive T-cell lymphoproliferative disorders of childhood".[2]

Classification

Pathophysiology

Histopathology

  • Histopathologic examination showed lymphocytic infiltrate with:[5]

Immunophenotype

Causes

Differential Diagnosis[1]

Epidemiology and Demographics

Hydroa vacciniforme-like lymphoma occurs mainly in the pediatric population from South America, Central America and Asia.[7] Although rare, it may present in adult population.[8]

Risk Factors

Natural History, Complications, and Prognosis

Diagnosis

History and Symptoms

Edema, blisters, ulcers, crusts and scars are evidenced in face and extremities of patients with Hydroa vacciniforme-like lymphomas. The mentioned lesions may or may not appear in sunlight exposed areas.[9] Patients may present with typical B symptoms,[10] which in some cases, are preceded by periorbtal swelling.[11]

Treatment

References

  1. ↑ 1.0 1.1 Barrionuevo C, Anderson VM, Zevallos-Giampietri E, Zaharia M, Misad O, Bravo F; et al. (2002). "Hydroa-like cutaneous T-cell lymphoma: a clinicopathologic and molecular genetic study of 16 pediatric cases from Peru". Appl Immunohistochem Mol Morphol. 10 (1): 7–14. PMID 11893040.
  2. ↑ 2.0 2.1 Swerdlow, Steven (2008). WHO classification of tumours of haematopoietic and lymphoid tissues. Lyon, France: International Agency for Research on Cancer. ISBN 9789283224310.
  3. ↑ "Hydroa vacciniforme-like lymphoma: a case report and literature review" (PDF).
  4. ↑ Oono T, Arata J, Masuda T, Ohtsuki Y (1986). "Coexistence of hydroa vacciniforme and malignant lymphoma". Arch Dermatol. 122 (11): 1306–9. PMID 3490832.
  5. ↑ Sangueza M, Plaza JA (2013). "Hydroa vacciniforme-like cutaneous T-cell lymphoma: clinicopathologic and immunohistochemical study of 12 cases". J Am Acad Dermatol. 69 (1): 112–9. doi:10.1016/j.jaad.2013.01.037. PMID 23541598.
  6. ↑ Xu Z, Lian S (2010). "Epstein-Barr virus-associated hydroa vacciniforme-like cutaneous lymphoma in seven Chinese children". Pediatr Dermatol. 27 (5): 463–9. doi:10.1111/j.1525-1470.2010.01094.x. PMID 20497358.
  7. ↑ Quintanilla-Martinez L, Ridaura C, Nagl F, Sáez-de-Ocariz M, Durán-McKinster C, Ruiz-Maldonado R; et al. (2013). "Hydroa vacciniforme-like lymphoma: a chronic EBV+ lymphoproliferative disorder with risk to develop a systemic lymphoma". Blood. 122 (18): 3101–10. doi:10.1182/blood-2013-05-502203. PMID 23982171.
  8. ↑ Wang RC, Chang ST, Hsieh YC, Huang WT, Hsu JD, Tseng CE; et al. (2014). "Spectrum of Epstein-Barr virus-associated T-cell lymphoproliferative disorder in adolescents and young adults in Taiwan". Int J Clin Exp Pathol. 7 (5): 2430–7. PMC 4069894. PMID 24966953.
  9. ↑ Doeden K, Molina-Kirsch H, Perez E, Warnke R, Sundram U (2008). "Hydroa-like lymphoma with CD56 expression". J Cutan Pathol. 35 (5): 488–94. doi:10.1111/j.1600-0560.2007.00836.x. PMID 17976208.
  10. ↑ Boddu D, George R, Nair S, Bindra M, G Mathew L (2014). "Hydroa Vacciniforme-Like Lymphoma: A Case Report From India". J Pediatr Hematol Oncol. doi:10.1097/MPH.0000000000000221. PMID 25072366.
  11. ↑ Plaza JA, Sangueza M (2015). "Hydroa vacciniforme-like lymphoma with primarily periorbital swelling: 7 cases of an atypical clinical manifestation of this rare cutaneous T-cell lymphoma". Am J Dermatopathol. 37 (1): 20–5. doi:10.1097/DAD.0000000000000158. PMID 25162933.


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